ID   NDD_BPR69               Reviewed;         152 AA.
AC   P42267;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   12-AUG-2020, entry version 35.
DE   RecName: Full=Nucleoid disruption protein;
DE   AltName: Full=Nuclear disruption protein;
GN   Name=ndd;
OS   Escherichia phage RB69 (Bacteriophage RB69).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Tevenvirinae; Mosigvirus.
OX   NCBI_TaxID=12353;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8163181; DOI=10.1016/0378-1119(94)90121-x;
RA   Bouet J.-Y., Woszczyk J., Repoila F., Francois V., Louarn J.-M.,
RA   Krisch H.M.;
RT   "Direct PCR sequencing of the ndd gene of bacteriophage T4: identification
RT   of a product involved in bacterial nucleoid disruption.";
RL   Gene 141:9-16(1994).
CC   -!- FUNCTION: Disorganizes the host nucleoid and inhibits replication, but
CC       without host DNA cleavage or degradation. Only the architecture of the
CC       nucleoid is affected. May act on the host chromosomal sequences that
CC       determine the structure of the nucleoid. Binds to dsDNA but not to
CC       ssDNA. {ECO:0000250|UniProtKB:P15556}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0098673; P:inhibition of host DNA replication by virus; IEA:UniProtKB-KW.
DR   GO; GO:0060153; P:modulation by virus of host cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR009514; Phage_Ndd.
DR   Pfam; PF06591; Phage_T4_Ndd; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Host-virus interaction;
KW   Inhibition of host DNA replication by virus;
KW   Modulation of host cell cycle by virus.
FT   CHAIN           1..152
FT                   /note="Nucleoid disruption protein"
FT                   /id="PRO_0000164964"
SQ   SEQUENCE   152 AA;  17181 MW;  E6259DA9E456A5B4 CRC64;
     MKYMTVTDLN NAGATVIGTI KGGEWFLGTP HKDILSKPGF YFLVSKLDGR PFSNPCVSAR
     FYVGNQRSKQ GFSAVLSHIR QRRSQLARTI ANNNMVYTVF YLPASKMKPL TTGFGKGQLA
     LAFTRNHHSE YQTLEEMNRM LADNFKFVLQ AY