ID   NDD_BPR70               Reviewed;         147 AA.
AC   P42268;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   23-FEB-2022, entry version 37.
DE   RecName: Full=Nucleoid disruption protein;
DE   AltName: Full=Nuclear disruption protein;
GN   Name=ndd;
OS   Enterobacteria phage RB70 (Bacteriophage RB70).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus;
OC   unclassified Tequatrovirus.
OX   NCBI_TaxID=36338;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8163181; DOI=10.1016/0378-1119(94)90121-x;
RA   Bouet J.-Y., Woszczyk J., Repoila F., Francois V., Louarn J.-M.,
RA   Krisch H.M.;
RT   "Direct PCR sequencing of the ndd gene of bacteriophage T4: identification
RT   of a product involved in bacterial nucleoid disruption.";
RL   Gene 141:9-16(1994).
CC   -!- FUNCTION: Disorganizes the host nucleoid and inhibits replication, but
CC       without host DNA cleavage or degradation. Only the architecture of the
CC       nucleoid is affected. May act on the host chromosomal sequences that
CC       determine the structure of the nucleoid. Binds to dsDNA but not to
CC       ssDNA. {ECO:0000250|UniProtKB:P15556}.
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DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0098673; P:inhibition of host DNA replication by virus; IEA:UniProtKB-KW.
DR   GO; GO:0060153; P:modulation by virus of host cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR009514; Phage_Ndd.
DR   Pfam; PF06591; Phage_T4_Ndd; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Host-virus interaction;
KW   Inhibition of host DNA replication by virus;
KW   Modulation of host cell cycle by virus.
FT   CHAIN           1..147
FT                   /note="Nucleoid disruption protein"
FT                   /id="PRO_0000164965"
SQ   SEQUENCE   147 AA;  16576 MW;  FF96691178966650 CRC64;
     MKYMTVTDLN NAGATVIGTI KGGEWFLGTP HKDILSKPGF YFLVSEFDGS CVSARFYVGN
     QRSKQGFSAV LSHIRQRRSQ LARTIANNNM AYTVFYLPAS KMKPLTTGFG KGQLALAFTR
     NHHSEYQTLE EMNRMLADNF KFVLQAY