NDD_BPT4
ID NDD_BPT4 Reviewed; 151 AA.
AC P15556;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 2.
DT 02-DEC-2020, entry version 70.
DE RecName: Full=Nucleoid disruption protein;
GN Name=ndd;
OS Enterobacteria phage T4 (Bacteriophage T4).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus.
OX NCBI_TaxID=10665;
OH NCBI_TaxID=562; Escherichia coli.
RN [1]
RP PRELIMINARY NUCLEOTIDE SEQUENCE.
RX PubMed=3280805; DOI=10.1016/0022-2836(88)90320-8;
RA Chapman D., Morad I., Kaufmann G., Gait M.J., Jorissen L., Snyder L.;
RT "Nucleotide and deduced amino acid sequence of stp: the bacteriophage T4
RT anticodon nuclease gene.";
RL J. Mol. Biol. 199:373-377(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=D;
RX PubMed=8163181; DOI=10.1016/0378-1119(94)90121-x;
RA Bouet J.-Y., Woszczyk J., Repoila F., Francois V., Louarn J.-M.,
RA Krisch H.M.;
RT "Direct PCR sequencing of the ndd gene of bacteriophage T4: identification
RT of a product involved in bacterial nucleoid disruption.";
RL Gene 141:9-16(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12626685; DOI=10.1128/mmbr.67.1.86-156.2003;
RA Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.;
RT "Bacteriophage T4 genome.";
RL Microbiol. Mol. Biol. Rev. 67:86-156(2003).
RN [4]
RP FUNCTION, AND DNA-BINDING.
RX PubMed=9748458; DOI=10.1128/jb.180.19.5227-5230.1998;
RA Bouet J.Y., Krisch H.M., Louarn J.M.;
RT "Ndd, the bacteriophage T4 protein that disrupts the Escherichia coli
RT nucleoid, has a DNA binding activity.";
RL J. Bacteriol. 180:5227-5230(1998).
CC -!- FUNCTION: Disorganizes the host nucleoid and inhibits replication, but
CC without host DNA cleavage or degradation. Only the architecture of the
CC nucleoid is affected. May act on the host chromosomal sequences that
CC determine the structure of the nucleoid. Binds to dsDNA but not to
CC ssDNA. {ECO:0000269|PubMed:9748458}.
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DR EMBL; X75802; CAA53438.1; -; Genomic_DNA.
DR EMBL; AF158101; AAD42615.1; -; Genomic_DNA.
DR PIR; S01868; NDBPT4.
DR RefSeq; NP_049879.1; NC_000866.4.
DR GeneID; 1258737; -.
DR KEGG; vg:1258737; -.
DR Proteomes; UP000009087; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0098673; P:inhibition of host DNA replication by virus; IEA:UniProtKB-KW.
DR GO; GO:0060153; P:modulation by virus of host cell cycle; IEA:UniProtKB-KW.
DR InterPro; IPR009514; Phage_Ndd.
DR Pfam; PF06591; Phage_T4_Ndd; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Host-virus interaction;
KW Inhibition of host DNA replication by virus;
KW Modulation of host cell cycle by virus; Reference proteome.
FT CHAIN 1..151
FT /note="Nucleoid disruption protein"
FT /id="PRO_0000164959"
FT VARIANT 63
FT /note="G -> D (in mutant NDD44)"
SQ SEQUENCE 151 AA; 16933 MW; 42ADBF271A743E20 CRC64;
MKYMTVTDLN DAGATVIGTI KGGEWFLGTP HKDILSKPGF YFLVSKLGGP FSNPCVSARF
YVGNQRSKQG FSAVLSHIRQ RRSQLARTIA NNNVPYTVFY LPASKMKPLT TGFGKGQLAL
AFTRNHHSEY QTLEEMNRML ADNFKFVLQA Y