ID   NDD_BPT6                Reviewed;         151 AA.
AC   P42265;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   23-FEB-2022, entry version 36.
DE   RecName: Full=Nucleoid disruption protein;
DE   AltName: Full=Nuclear disruption protein;
GN   Name=ndd;
OS   Enterobacteria phage T6 (Bacteriophage T6).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus;
OC   Enterobacteria virus T6.
OX   NCBI_TaxID=10666;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8163181; DOI=10.1016/0378-1119(94)90121-x;
RA   Bouet J.-Y., Woszczyk J., Repoila F., Francois V., Louarn J.-M.,
RA   Krisch H.M.;
RT   "Direct PCR sequencing of the ndd gene of bacteriophage T4: identification
RT   of a product involved in bacterial nucleoid disruption.";
RL   Gene 141:9-16(1994).
CC   -!- FUNCTION: Disorganizes the host nucleoid and inhibits replication, but
CC       without host DNA cleavage or degradation. Only the architecture of the
CC       nucleoid is affected. May act on the host chromosomal sequences that
CC       determine the structure of the nucleoid. Binds to dsDNA but not to
CC       ssDNA. {ECO:0000250|UniProtKB:P15556}.
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DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0098673; P:inhibition of host DNA replication by virus; IEA:UniProtKB-KW.
DR   GO; GO:0060153; P:modulation by virus of host cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR009514; Phage_Ndd.
DR   Pfam; PF06591; Phage_T4_Ndd; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Host-virus interaction;
KW   Inhibition of host DNA replication by virus;
KW   Modulation of host cell cycle by virus.
FT   CHAIN           1..151
FT                   /note="Nucleoid disruption protein"
FT                   /id="PRO_0000164960"
SQ   SEQUENCE   151 AA;  16905 MW;  D314A2B49F555862 CRC64;
     MKYMTVTDLN NAGATVIGTI KGGEWFLGTP HKDILSKPGF YFLVSKLGGP FSSPCVSARF
     YVGNQRSKQG FSAVLSHIRQ RRSQLARTIA NNNVPYTVFY LPASKMKPLT TGFGKGQLAL
     AFTRNHHSEY QTLEEMNRML ADNFKFVLQA Y