NDE1_CHICK
ID NDE1_CHICK Reviewed; 342 AA.
AC Q5ZMC9;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Nuclear distribution protein nudE homolog 1;
GN Name=NDE1; ORFNames=RCJMB04_2i10;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Required for centrosome duplication and formation and
CC function of the mitotic spindle. {ECO:0000250}.
CC -!- SUBUNIT: Self-associates. Interacts with PAFAH1B1 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to the
CC interphase centrosome and to the mitotic spindle. {ECO:0000250}.
CC -!- PTM: Phosphorylated in mitosis. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nudE family. {ECO:0000305}.
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DR EMBL; AJ719455; CAG31114.1; -; mRNA.
DR RefSeq; NP_001006169.1; NM_001006169.1.
DR AlphaFoldDB; Q5ZMC9; -.
DR SMR; Q5ZMC9; -.
DR STRING; 9031.ENSGALP00000010488; -.
DR PaxDb; Q5ZMC9; -.
DR Ensembl; ENSGALT00000066175; ENSGALP00000048047; ENSGALG00000032590.
DR Ensembl; ENSGALT00000101602; ENSGALP00000071304; ENSGALG00000032590.
DR GeneID; 416597; -.
DR KEGG; gga:416597; -.
DR CTD; 54820; -.
DR VEuPathDB; HostDB:geneid_416597; -.
DR eggNOG; KOG1853; Eukaryota.
DR GeneTree; ENSGT00390000000111; -.
DR HOGENOM; CLU_057872_0_0_1; -.
DR InParanoid; Q5ZMC9; -.
DR OMA; CERPATL; -.
DR OrthoDB; 1082224at2759; -.
DR PhylomeDB; Q5ZMC9; -.
DR Reactome; R-GGA-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR Reactome; R-GGA-2467813; Separation of Sister Chromatids.
DR Reactome; R-GGA-2500257; Resolution of Sister Chromatid Cohesion.
DR Reactome; R-GGA-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR Reactome; R-GGA-380259; Loss of Nlp from mitotic centrosomes.
DR Reactome; R-GGA-380270; Recruitment of mitotic centrosome proteins and complexes.
DR Reactome; R-GGA-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR Reactome; R-GGA-380320; Recruitment of NuMA to mitotic centrosomes.
DR Reactome; R-GGA-5620912; Anchoring of the basal body to the plasma membrane.
DR Reactome; R-GGA-5663220; RHO GTPases Activate Formins.
DR Reactome; R-GGA-8854518; AURKA Activation by TPX2.
DR Reactome; R-GGA-9648025; EML4 and NUDC in mitotic spindle formation.
DR PRO; PR:Q5ZMC9; -.
DR Proteomes; UP000000539; Chromosome 14.
DR Bgee; ENSGALG00000032590; Expressed in testis and 13 other tissues.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031616; C:spindle pole centrosome; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0051298; P:centrosome duplication; ISS:UniProtKB.
DR GO; GO:0051642; P:centrosome localization; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR GO; GO:0051303; P:establishment of chromosome localization; IBA:GO_Central.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IBA:GO_Central.
DR GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR GO; GO:0007100; P:mitotic centrosome separation; IBA:GO_Central.
DR GO; GO:0047496; P:vesicle transport along microtubule; IBA:GO_Central.
DR InterPro; IPR033494; NUDE.
DR InterPro; IPR006964; NUDE_dom.
DR PANTHER; PTHR10921; PTHR10921; 1.
DR Pfam; PF04880; NUDE_C; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW Microtubule; Mitosis; Phosphoprotein; Reference proteome.
FT CHAIN 1..342
FT /note="Nuclear distribution protein nudE homolog 1"
FT /id="PRO_0000240205"
FT REGION 89..157
FT /note="Interaction with PAFAH1B1"
FT /evidence="ECO:0000250"
FT REGION 182..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 45..189
FT /evidence="ECO:0000255"
SQ SEQUENCE 342 AA; 39564 MW; B1F4EDF5F2D474E8 CRC64;
MEDSEEHHFS SVEEETRYWK ELAMKYKQCA ENIQEELCEF QEGSREYEAE LETQLQQTES
RNRDLLSENN RLRIELESVK EKFEMQHSEW YRQVSALEDD LAQTKAIKDQ LQKYIRELEQ
ANDDLERAKR AAIMSLEDFE QRLNQAIERN AFLESELDEK ENLLESVQRL KDEARDLRQE
LAVQQKQEKP KTPMRTSLET ERTDTAVQAS LSLPSTPSLH RAPNINIPTP ATFRRGFEDS
YCATPLTPAA RISALNIMGD LLRKVGALES KLASCRNFVY DQSPDRTTVS MYMNRDALET
RMSPHQPLCD TGLVKRLEFG TRPSSTPGPM SHPSQSVVKM LL
