ID   NDE1_CRYNB              Reviewed;         666 AA.
AC   P0CP39; Q55N49; Q5KBH9;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Nuclear distribution protein nudE homolog 1;
GN   Name=NDE1; OrderedLocusNames=CNBH2350;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required for nuclear migration. {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates. Interacts with PAC1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Localizes to the
CC       plus ends of microtubules. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nudE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL19136.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AAEY01000042; EAL19136.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_773783.1; XM_768690.1.
DR   AlphaFoldDB; P0CP39; -.
DR   SMR; P0CP39; -.
DR   PRIDE; P0CP39; -.
DR   EnsemblFungi; EAL19136; EAL19136; CNBH2350.
DR   GeneID; 4937758; -.
DR   KEGG; cnb:CNBH2350; -.
DR   HOGENOM; CLU_382703_0_0_1; -.
DR   Proteomes; UP000001435; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   InterPro; IPR033494; NUDE.
DR   InterPro; IPR006964; NUDE_dom.
DR   PANTHER; PTHR10921; PTHR10921; 1.
DR   Pfam; PF04880; NUDE_C; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Transport.
FT   CHAIN           1..666
FT                   /note="Nuclear distribution protein nudE homolog 1"
FT                   /id="PRO_0000410177"
FT   REGION          40..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          220..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          369..388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          397..666
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          14..195
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        249..293
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..387
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        397..413
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        447..465
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..495
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        516..561
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        577..596
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        616..640
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   666 AA;  72160 MW;  300FFDD84580B655 CRC64;
     MVDDEDDITF DSPEEEIAHY REKYRQALDM LTDTRAELEE FQQSSKELED EMEQELAAND
     KQQADLREKI KRLDAEKEEW RTKHIALQKM HSSTTSAMQR EMDNLRSERD KTLVALRDLE
     MGNDELERNE RVAISSLLDL ESKYNRAIEE KTLLEQDLAQ KDELETETQR LKDELREANE
     EISILKDQLA RAIATPPSSV STSSPIHDAA CDLSRIHLSD DINASPLPPP VPSKNKSITP
     EGHSPRRGLS RSGTMSSIPV ASPSTKRFSQ QIPHSPSFST LSRSTTSRNL AAAAGTPGSP
     ALARSRSGIP QASPARGIVL ASHQQTKSRG FKLLHDLQAR LKATDDKLGG AKVPRRNVSN
     PASVFGVGKR VTSTTSTTSS TTTAPAPHAR VTALAKDHNT TPTAQSQQFP GSGIMSPGWV
     LVGEGEGEDT PTGPWSMTLP AEPNSPLDPT FRSSSTTSNR SLPSRPGIPS PLASGSARST
     TSGTAQRQAG QRPSSRLGLK ASRRDSEARP LSPSMIPVPS FSSRPMSPDV YQPLRSATPT
     SGFSSFSASA STSNPPRPNS RTGKRNPIGR GPPPLSSSTR LHHQRSRQSL SGAGPTPTTG
     ADKVERAKRG PRRSSLSNMD KPSLMSASPG SRTPSGRPTS VHVFRETPPP VPRIPSAILK
     ESKVKK