NDE1_CRYNJ
ID NDE1_CRYNJ Reviewed; 666 AA.
AC P0CP38; Q55N49; Q5KBH9;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 44.
DE RecName: Full=Nuclear distribution protein nudE homolog 1;
GN Name=NDE1; OrderedLocusNames=CNI02480;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Required for nuclear migration. {ECO:0000250}.
CC -!- SUBUNIT: Self-associates. Interacts with PAC1 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Localizes to the
CC plus ends of microtubules. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nudE family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAW45554.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE017349; AAW45554.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_572861.1; XM_572861.1.
DR AlphaFoldDB; P0CP38; -.
DR SMR; P0CP38; -.
DR STRING; 5207.AAW45554; -.
DR PaxDb; P0CP38; -.
DR EnsemblFungi; AAW45554; AAW45554; CNI02480.
DR GeneID; 3259703; -.
DR KEGG; cne:CNI02480; -.
DR eggNOG; KOG1853; Eukaryota.
DR InParanoid; P0CP38; -.
DR OrthoDB; 962298at2759; -.
DR Proteomes; UP000002149; Chromosome 9.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0051642; P:centrosome localization; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR GO; GO:0051303; P:establishment of chromosome localization; IBA:GO_Central.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IBA:GO_Central.
DR GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR GO; GO:0047496; P:vesicle transport along microtubule; IBA:GO_Central.
DR InterPro; IPR033494; NUDE.
DR InterPro; IPR006964; NUDE_dom.
DR PANTHER; PTHR10921; PTHR10921; 1.
DR Pfam; PF04880; NUDE_C; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome;
KW Transport.
FT CHAIN 1..666
FT /note="Nuclear distribution protein nudE homolog 1"
FT /id="PRO_0000240223"
FT REGION 40..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 14..195
FT /evidence="ECO:0000255"
FT COMPBIAS 249..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 666 AA; 72150 MW; 9F0FFDD845824B7A CRC64;
MVDDEDDITF DSPEEEIAHY REKYRQALDM LTDTRAELEE FQQSSKELED EMEQELAAND
KQQADLREKI KRLDAEKEEW RTKHIALQKM HSSTTSAMQR EMDNLRSERD KTLVALRDLE
MGNDELERNE RVAISSLLDL ESKYNRAIEE KTLLEQDLAQ KDELETETQR LKDELREANE
EISILKDQLA RAIATPPSSV STSSPIHDAA CDLSRIHLSD DINASPLPPP VPSKNKSITP
EGHSPRRGLS RSGTMSSIPV ASPSTKRFSQ QIPHSPSFST LSRSTTSRNL AAAAGTPGSP
ALARSRSGIP QASPARGIVL ASHQQTKSRG FKLLHDLQAR LKATDDKLGG AKVPRRNVSN
PASVFGVGKR VTSTTSTTSS TTTAPAPHAR VTALAKDHNT TPTAQSQQFP GSGIMSPGWV
LVGEGEGEDT PTGPWSMTLP AEPNSPLDPT FRSSSTTSNR SLPSRPGIPS PLASGSARST
TSGTAQRQAG QRPSSRLGLK ASRRDSEARP LSPSMIPVPS FSSRPMSPDV YQPLRSATPT
SGFSSFSASA STSNPPRPNS RTGKRNPIGR GPPPLSSSTR LHHQRSRQSL SGAGPTPTTG
ADKVERAKRG PRRSSLSNMD KPSLMSASSG SRTPSGRPTS VHVFRETPPP VPRIPSAILK
ESKVKK
