NDE1_NEUCR
ID NDE1_NEUCR Reviewed; 697 AA.
AC O13335; U9W8Z5;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Nuclear distribution protein nudE homolog 1;
DE AltName: Full=Nuclear distribution protein ro-11;
DE AltName: Full=Ropy-11;
GN Name=ro-11; Synonyms=nde1; ORFNames=B13M15.120, NCU08566;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=10361308; DOI=10.1046/j.1365-2958.1999.01421.x;
RA Minke P.F., Lee I.H., Tinsley J.H., Bruno K.S., Plamann M.;
RT "Neurospora crassa ro-10 and ro-11 genes encode novel proteins required for
RT nuclear distribution.";
RL Mol. Microbiol. 32:1065-1076(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Required for nuclear migration within hyphae during
CC vegetative growth. {ECO:0000269|PubMed:10361308}.
CC -!- SUBUNIT: Self-associates. Interacts with nudF (nmp-1 or nmp-2) (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Localizes to the
CC plus ends of microtubules. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nudE family. {ECO:0000305}.
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DR EMBL; AF015560; AAB69381.1; -; Genomic_DNA.
DR EMBL; BX897673; CAE85502.1; -; Genomic_DNA.
DR EMBL; CM002238; ESA43450.1; -; Genomic_DNA.
DR PIR; T03834; T03834.
DR RefSeq; XP_011393962.1; XM_011395660.1.
DR AlphaFoldDB; O13335; -.
DR SMR; O13335; -.
DR STRING; 5141.EFNCRP00000004666; -.
DR PRIDE; O13335; -.
DR EnsemblFungi; ESA43450; ESA43450; NCU08566.
DR GeneID; 3878983; -.
DR KEGG; ncr:NCU08566; -.
DR VEuPathDB; FungiDB:NCU08566; -.
DR HOGENOM; CLU_034391_0_0_1; -.
DR InParanoid; O13335; -.
DR OMA; WKTKYKQ; -.
DR Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0051642; P:centrosome localization; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR GO; GO:0051303; P:establishment of chromosome localization; IBA:GO_Central.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IBA:GO_Central.
DR GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR GO; GO:0047496; P:vesicle transport along microtubule; IBA:GO_Central.
DR InterPro; IPR033494; NUDE.
DR InterPro; IPR006964; NUDE_dom.
DR PANTHER; PTHR10921; PTHR10921; 1.
DR Pfam; PF04880; NUDE_C; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome;
KW Transport.
FT CHAIN 1..697
FT /note="Nuclear distribution protein nudE homolog 1"
FT /id="PRO_0000240226"
FT REGION 204..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 11..195
FT /evidence="ECO:0000255"
FT COMPBIAS 204..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 74606 MW; EF76C0A086388082 CRC64;
MAADVPGSPL AKNATTEEAL AWYKSQYEEL EQELKEFQQS SKELEAELEK DLDAADKRER
ALQQKAEGLS YEVEEWKRKY KESKSEANAA QSALEKEITA LRETNRTLQL KLRDIEVAND
DFERQARNTS SSLEDLESKY NVAIERAVMM EEEIKIGEQE RERLRVEAQR LREELSDLKI
EAEILQSKLR KHQARGHLTQ ITTTIAPAPA SPLSTASSPL VSTPPDTKSL STIDTLSEVQ
DPPSPPMSDA SLGKGLRASR STPVKQTASR PGGCRTPKTS ISKSAAAKSS AQATHKANQS
FSENNITPKP KPLSSSTSSQ SNRPSNGRFN TNSYPMVRTP SSRPSGARAA ERPRAPVHRI
PPSNSLTHIR TLTAQMQKLE ARVHSARSKL PATAQTPPKQ SPRFSGGIGG LAATVAMRGK
KQRGVGASTS SLNLLDDDNA SDISGTHSNP DFRSSTLNLS KHIPRLSTSG VSRIAFGPLP
IRHPASAAAS TTSTSTATAT NVDSEVSRPS SRASSSGYGR PISRADSHST AASGYMPSSS
SRPISRTSLP GHGTRTPVGS WPRSSGNLSA YGHGPAHSQA SISYSTAEED ELTDDGQREL
RSKTTPARRR TGTLSARDAP DHHHTGIPIP GSGGNRRQSG SSSASRSSVT GSLSLRRQSN
AAALGHGHGH NAGYGHGHGT VPGGTTVRKV VDLGETY
