ID   NDE1_XENTR              Reviewed;         349 AA.
AC   Q66JL0;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Nuclear distribution protein nudE homolog 1;
GN   Name=nde1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for centrosome duplication and formation and
CC       function of the mitotic spindle. {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates. Interacts with pafah1b1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to the
CC       interphase centrosome and to the mitotic spindle. {ECO:0000250}.
CC   -!- PTM: Phosphorylated in mitosis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nudE family. {ECO:0000305}.
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DR   EMBL; BC080874; AAH80874.1; -; mRNA.
DR   RefSeq; NP_001007996.1; NM_001007995.1.
DR   RefSeq; XP_017953066.1; XM_018097577.1.
DR   AlphaFoldDB; Q66JL0; -.
DR   SMR; Q66JL0; -.
DR   STRING; 8364.ENSXETP00000012155; -.
DR   PaxDb; Q66JL0; -.
DR   PRIDE; Q66JL0; -.
DR   DNASU; 493358; -.
DR   GeneID; 493358; -.
DR   KEGG; xtr:493358; -.
DR   CTD; 54820; -.
DR   Xenbase; XB-GENE-1005616; nde1.
DR   eggNOG; KOG1853; Eukaryota.
DR   HOGENOM; CLU_057872_0_0_1; -.
DR   InParanoid; Q66JL0; -.
DR   OMA; EQTVNRR; -.
DR   OrthoDB; 1082224at2759; -.
DR   PhylomeDB; Q66JL0; -.
DR   TreeFam; TF325693; -.
DR   Reactome; R-XTR-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-XTR-2467813; Separation of Sister Chromatids.
DR   Reactome; R-XTR-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-XTR-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR   Reactome; R-XTR-380259; Loss of Nlp from mitotic centrosomes.
DR   Reactome; R-XTR-380270; Recruitment of mitotic centrosome proteins and complexes.
DR   Reactome; R-XTR-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR   Reactome; R-XTR-380320; Recruitment of NuMA to mitotic centrosomes.
DR   Reactome; R-XTR-5620912; Anchoring of the basal body to the plasma membrane.
DR   Reactome; R-XTR-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-XTR-8854518; AURKA Activation by TPX2.
DR   Reactome; R-XTR-9648025; EML4 and NUDC in mitotic spindle formation.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000005528; Expressed in 4-cell stage embryo and 12 other tissues.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031616; C:spindle pole centrosome; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0051298; P:centrosome duplication; ISS:UniProtKB.
DR   GO; GO:0051642; P:centrosome localization; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR   GO; GO:0051303; P:establishment of chromosome localization; IBA:GO_Central.
DR   GO; GO:0000132; P:establishment of mitotic spindle orientation; IBA:GO_Central.
DR   GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR   GO; GO:0007100; P:mitotic centrosome separation; IBA:GO_Central.
DR   GO; GO:0032536; P:regulation of cell projection size; IEA:Ensembl.
DR   GO; GO:0047496; P:vesicle transport along microtubule; IBA:GO_Central.
DR   InterPro; IPR033494; NUDE.
DR   InterPro; IPR006964; NUDE_dom.
DR   PANTHER; PTHR10921; PTHR10921; 1.
DR   Pfam; PF04880; NUDE_C; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Microtubule; Mitosis; Phosphoprotein; Reference proteome.
FT   CHAIN           1..349
FT                   /note="Nuclear distribution protein nudE homolog 1"
FT                   /id="PRO_0000240208"
FT   REGION          182..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          23..189
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        186..201
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   349 AA;  39553 MW;  8CC4858A8C110F3A CRC64;
     MDDLENNIFN SVEEEIIYWK SVAMKYKTCS EEAQQELQEF QEASREYEAE LEAQLQQIEG
     RNRDLFSENN RLRMELDGIK EKYEEQHSEN YVQICSLEGD LSQTKAVRDQ LQKYIRELEQ
     ANDDLERAKR ATIMSLEDFE QRLNQAIERN AFLESELDEK ENLLESVQRL KDEARDLRQE
     LAVQQKQEKP KSNMGSPETE RMDTSVKASV AIPSAPLTPL SQRGCASTLT SPLSFRTSLD
     DGYSGTPLTP CARISALNIV GDLLRKVGAL ESKLASCRNF VHEQSPNRPL TSVSARMNKT
     REGIENRLSM ASGSSVEKGL IKRLEFGSLP SNTPVQGMHS PQGVVKMII