ID   NDE1_YEAST              Reviewed;         189 AA.
AC   Q06568; D6VYQ1;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Nuclear distribution protein nudE homolog 1;
DE   AltName: Full=Nuclear distribution protein nudE-like 1;
GN   Name=NDL1; OrderedLocusNames=YLR254C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169871;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA   Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA   Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA   Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA   Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA   Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA   Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA   Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA   Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA   Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA   Zollner A., Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   FUNCTION, SELF-ASSOCIATION, INTERACTION WITH PAC1, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=15965467; DOI=10.1038/ncb1273;
RA   Li J., Lee W.-L., Cooper J.A.;
RT   "NudEL targets dynein to microtubule ends through LIS1.";
RL   Nat. Cell Biol. 7:686-690(2005).
CC   -!- FUNCTION: Required for nuclear migration to the bud neck during cell
CC       division. Targets cytoplasmic dynein to microtubule plus ends thereby
CC       promoting dynein-mediated microtubule sliding along the bud cortex and
CC       consequently the movement of the mitotic spindle to the bud neck.
CC       {ECO:0000269|PubMed:15965467}.
CC   -!- SUBUNIT: Self-associates. Interacts with PAC1.
CC       {ECO:0000269|PubMed:15965467}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15965467}. Cytoplasm,
CC       cytoskeleton {ECO:0000269|PubMed:15965467}. Note=Also localizes to the
CC       plus ends of cytoplasmic microtubules, and this requires PAC1.
CC   -!- SIMILARITY: Belongs to the nudE family. {ECO:0000305}.
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DR   EMBL; U20865; AAB67401.1; -; Genomic_DNA.
DR   EMBL; AY558212; AAS56538.1; -; Genomic_DNA.
DR   EMBL; BK006945; DAA09567.1; -; Genomic_DNA.
DR   PIR; S59399; S59399.
DR   RefSeq; NP_013355.1; NM_001182141.1.
DR   AlphaFoldDB; Q06568; -.
DR   SMR; Q06568; -.
DR   BioGRID; 31521; 293.
DR   DIP; DIP-1486N; -.
DR   IntAct; Q06568; 5.
DR   MINT; Q06568; -.
DR   STRING; 4932.YLR254C; -.
DR   MaxQB; Q06568; -.
DR   PaxDb; Q06568; -.
DR   PRIDE; Q06568; -.
DR   EnsemblFungi; YLR254C_mRNA; YLR254C; YLR254C.
DR   GeneID; 850956; -.
DR   KEGG; sce:YLR254C; -.
DR   SGD; S000004244; NDL1.
DR   VEuPathDB; FungiDB:YLR254C; -.
DR   eggNOG; ENOG502S6CQ; Eukaryota.
DR   HOGENOM; CLU_125075_0_0_1; -.
DR   InParanoid; Q06568; -.
DR   OMA; AASHEYE; -.
DR   BioCyc; YEAST:G3O-32358-MON; -.
DR   PRO; PR:Q06568; -.
DR   Proteomes; UP000002311; Chromosome XII.
DR   RNAct; Q06568; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0005881; C:cytoplasmic microtubule; IDA:SGD.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0051010; F:microtubule plus-end binding; IDA:SGD.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030473; P:nuclear migration along microtubule; IMP:SGD.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Microtubule; Mitosis; Nucleus; Reference proteome; Transport.
FT   CHAIN           1..189
FT                   /note="Nuclear distribution protein nudE homolog 1"
FT                   /id="PRO_0000240229"
FT   REGION          114..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          4..121
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   189 AA;  21530 MW;  E3E6EAC07C5B595A CRC64;
     MVPNLDLETA IQIISSLETQ LSELEGATKE YENDLEQVIS KLKSDLLESQ QQNKCNKKQI
     TDLEIQVDEL ENENIQLRNK IETLQLESDR RLERNVLLEH ELLDTKEALQ KLRVSKEEAT
     SGETRRNTRS LPSQNKKMKL FKDTIKVSTT SSTLYLQNMA KTNNAARSHC NIPNTQITQS
     TVIATTSSV