NDEL1_CHICK
ID NDEL1_CHICK Reviewed; 343 AA.
AC Q5ZKH4;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Nuclear distribution protein nudE-like 1;
GN Name=NDEL1; ORFNames=RCJMB04_10n4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Required for organization of the cellular microtubule array
CC and microtubule anchoring at the centrosome. Positively regulates the
CC activity of the minus-end directed microtubule motor protein dynein.
CC May enhance dynein-mediated microtubule sliding by targeting dynein to
CC the microtubule plus end. Positively regulates lysosome peripheral
CC distribution and ruffled border formation in osteoclasts. {ECO:0000250,
CC ECO:0000250|UniProtKB:Q9ERR1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to the
CC interphase centrosome and the mitotic spindle. {ECO:0000250}.
CC -!- PTM: Phosphorylated in mitosis. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nudE family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ720110; CAG31769.1; -; mRNA.
DR RefSeq; NP_001025867.1; NM_001030696.1.
DR AlphaFoldDB; Q5ZKH4; -.
DR SMR; Q5ZKH4; -.
DR STRING; 9031.ENSGALP00000001751; -.
DR Ensembl; ENSGALT00000001753; ENSGALP00000001751; ENSGALG00000001163.
DR Ensembl; ENSGALT00000034920; ENSGALP00000034276; ENSGALG00000001163.
DR Ensembl; ENSGALT00000053269; ENSGALP00000051740; ENSGALG00000001163.
DR GeneID; 417317; -.
DR KEGG; gga:417317; -.
DR CTD; 81565; -.
DR VEuPathDB; HostDB:geneid_417317; -.
DR eggNOG; KOG1853; Eukaryota.
DR GeneTree; ENSGT00390000000111; -.
DR HOGENOM; CLU_057872_1_0_1; -.
DR InParanoid; Q5ZKH4; -.
DR OMA; EVEALKX; -.
DR OrthoDB; 1082224at2759; -.
DR PhylomeDB; Q5ZKH4; -.
DR Reactome; R-GGA-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR Reactome; R-GGA-2467813; Separation of Sister Chromatids.
DR Reactome; R-GGA-2500257; Resolution of Sister Chromatid Cohesion.
DR Reactome; R-GGA-5663220; RHO GTPases Activate Formins.
DR Reactome; R-GGA-9648025; EML4 and NUDC in mitotic spindle formation.
DR PRO; PR:Q5ZKH4; -.
DR Proteomes; UP000000539; Chromosome 18.
DR Bgee; ENSGALG00000001163; Expressed in lung and 14 other tissues.
DR ExpressionAtlas; Q5ZKH4; baseline and differential.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0051642; P:centrosome localization; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR GO; GO:0051303; P:establishment of chromosome localization; IBA:GO_Central.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IBA:GO_Central.
DR GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR GO; GO:0007100; P:mitotic centrosome separation; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR GO; GO:0060052; P:neurofilament cytoskeleton organization; IEA:InterPro.
DR GO; GO:1900029; P:positive regulation of ruffle assembly; ISS:UniProtKB.
DR GO; GO:0010975; P:regulation of neuron projection development; IBA:GO_Central.
DR GO; GO:0047496; P:vesicle transport along microtubule; IBA:GO_Central.
DR InterPro; IPR033493; NDEL1.
DR InterPro; IPR033494; NUDE.
DR InterPro; IPR006964; NUDE_dom.
DR PANTHER; PTHR10921; PTHR10921; 1.
DR PANTHER; PTHR10921:SF0; PTHR10921:SF0; 1.
DR Pfam; PF04880; NUDE_C; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein;
KW Reference proteome; Transport.
FT CHAIN 1..343
FT /note="Nuclear distribution protein nudE-like 1"
FT /id="PRO_0000240216"
FT REGION 184..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 25..190
FT /evidence="ECO:0000255"
SQ SEQUENCE 343 AA; 38230 MW; 9D6609DE9AD459E7 CRC64;
MDSEEIPTFS SPKEETAYWK ELSLKYKQSF QEAREELAEF QEGSRELEAE LEAQLVQAEQ
RNRDLQADNQ RLKYEVETLK EKLEHQYAQS YKQVSLLEDD LSQTRAIKDQ LHKYVRELEQ
ANDDLERAKR ATIVSLEDFE QRLNQAIERN AFLESELDDK ESLLVSVQRL KDEARDLRQE
LAVRERQQEV TRKSAPSSPT LDCEKMDSAV QASLSLPATP VGKGSENSFP SPKAIPNGFG
TSPLTPSARI SALNIVGDLL RKVGALESKL AACRNFAKDQ ASRKSYISGN ANSSMMSSNG
TKYPHPGHTS FFDKGAVNGF DQGTPGLGAS RPSSAPGMLP LSV
