ID   NDEL1_XENTR             Reviewed;         346 AA.
AC   Q28CJ6;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Nuclear distribution protein nudE-like 1;
GN   Name=ndel1; ORFNames=TEgg108o19.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for organization of the cellular microtubule array
CC       and microtubule anchoring at the centrosome. Positively regulates the
CC       activity of the minus-end directed microtubule motor protein dynein.
CC       May enhance dynein-mediated microtubule sliding by targeting dynein to
CC       the microtubule plus end. Positively regulates lysosome peripheral
CC       distribution and ruffled border formation in osteoclasts. {ECO:0000250,
CC       ECO:0000250|UniProtKB:Q9ERR1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to the
CC       interphase centrosome and the mitotic spindle. {ECO:0000250}.
CC   -!- PTM: Phosphorylated in mitosis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nudE family. {ECO:0000305}.
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DR   EMBL; CR926344; CAJ81964.1; -; mRNA.
DR   RefSeq; NP_001016201.1; NM_001016201.2.
DR   AlphaFoldDB; Q28CJ6; -.
DR   SMR; Q28CJ6; -.
DR   STRING; 8364.ENSXETP00000026720; -.
DR   ABCD; Q28CJ6; 5 sequenced antibodies.
DR   GeneID; 548955; -.
DR   KEGG; xtr:548955; -.
DR   CTD; 81565; -.
DR   Xenbase; XB-GENE-989304; ndel1.
DR   eggNOG; KOG1853; Eukaryota.
DR   InParanoid; Q28CJ6; -.
DR   OrthoDB; 1082224at2759; -.
DR   Reactome; R-XTR-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-XTR-2467813; Separation of Sister Chromatids.
DR   Reactome; R-XTR-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-XTR-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-XTR-9648025; EML4 and NUDC in mitotic spindle formation.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0051642; P:centrosome localization; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR   GO; GO:0051303; P:establishment of chromosome localization; IBA:GO_Central.
DR   GO; GO:0000132; P:establishment of mitotic spindle orientation; IBA:GO_Central.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR   GO; GO:0007100; P:mitotic centrosome separation; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR   GO; GO:0060052; P:neurofilament cytoskeleton organization; IEA:InterPro.
DR   GO; GO:1900029; P:positive regulation of ruffle assembly; ISS:UniProtKB.
DR   GO; GO:0010975; P:regulation of neuron projection development; IBA:GO_Central.
DR   GO; GO:0047496; P:vesicle transport along microtubule; IBA:GO_Central.
DR   InterPro; IPR033493; NDEL1.
DR   InterPro; IPR033494; NUDE.
DR   InterPro; IPR006964; NUDE_dom.
DR   PANTHER; PTHR10921; PTHR10921; 1.
DR   PANTHER; PTHR10921:SF0; PTHR10921:SF0; 1.
DR   Pfam; PF04880; NUDE_C; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein;
KW   Reference proteome; Transport.
FT   CHAIN           1..346
FT                   /note="Nuclear distribution protein nudE-like 1"
FT                   /id="PRO_0000240221"
FT   REGION          184..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          325..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..190
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        188..205
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        331..346
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   346 AA;  38472 MW;  458095BF218316A1 CRC64;
     MENEEIPEFL SPKEEIVYWR ELAKRLKQSY QEARDELIEF QEGSRELEAE LETQLVQAEQ
     RNRDLLSDNQ RLKCEVESLK EKLEHQYAQS YKQVSLLEDE LARARSIKDQ LHKYVRELEQ
     ANDDLERAKR ATIVSLEDFE QRLNQAIERN AFLESELDEK ESLLVSVQRL KDEARDLRQE
     LAVRERQTNG TRKSAPSSPT LDCDKTDSAV QASLSLPATP VGKVCDNSFT PPKGIPNGFG
     TTPLTPSARI SALNIVGDLL RKVGALESKL AACRNFAKDQ ASRKSYTPVG LNSSGGGSSA
     LNSSGVKYSH AGHTSFFDKG AVNGYDPPGV LGSRPPSPPG MLPLSV