NDF1_CAEEL
ID NDF1_CAEEL Reviewed; 192 AA.
AC P46581;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Neurogenic differentiation factor 1;
DE AltName: Full=NeuroD;
GN Name=cnd-1; ORFNames=C34E10.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=10976055; DOI=10.1242/dev.127.19.4239;
RA Hallam S., Singer E., Waring D., Jin Y.;
RT "The C. elegans NeuroD homolog cnd-1 functions in multiple aspects of motor
RT neuron fate specification.";
RL Development 127:4239-4252(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=18587405; DOI=10.1038/nmeth.1228;
RA Murray J.I., Bao Z., Boyle T.J., Boeck M.E., Mericle B.L., Nicholas T.J.,
RA Zhao Z., Sandel M.J., Waterston R.H.;
RT "Automated analysis of embryonic gene expression with cellular resolution
RT in C. elegans.";
RL Nat. Methods 5:703-709(2008).
RN [4]
RP FUNCTION.
RX PubMed=32665354; DOI=10.1534/g3.120.401547;
RA Zhang A., Noma K., Yan D.;
RT "Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans.";
RL G3 (Bethesda) 10:3271-3278(2020).
CC -!- FUNCTION: Acts as a transcriptional regulator whose activity is
CC required for several aspects of motor neuron fate specification,
CC including cell division patterns, proper spatiotemporal expression of
CC fate-specific markers, and normal axonal morphology and pathfinding
CC (PubMed:10976055). Involved in regulating glial specification
CC (PubMed:32665354). {ECO:0000269|PubMed:10976055,
CC ECO:0000269|PubMed:32665354}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed in neuroblasts of the AB lineage. More
CC specifically in precursors of the embryonic ventral cord motor neurons.
CC Expressed to a lesser degree in the EMS lineage which generates mostly
CC endoderm and mesoderm tissues. {ECO:0000269|PubMed:10976055,
CC ECO:0000269|PubMed:18587405}.
CC -!- DEVELOPMENTAL STAGE: Expressed at the 14 cell embryo stage.
CC {ECO:0000269|PubMed:10976055}.
CC -!- DISRUPTION PHENOTYPE: Defects in axonal morphology and synaptic
CC connectivity of the ventral cord motor neurons.
CC {ECO:0000269|PubMed:10976055}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO080774; CCD66651.1; -; Genomic_DNA.
DR PIR; T15764; T15764.
DR RefSeq; NP_498115.1; NM_065714.5.
DR AlphaFoldDB; P46581; -.
DR SMR; P46581; -.
DR BioGRID; 48043; 4.
DR IntAct; P46581; 4.
DR STRING; 6239.C34E10.7; -.
DR EPD; P46581; -.
DR PaxDb; P46581; -.
DR EnsemblMetazoa; C34E10.7.1; C34E10.7.1; WBGene00000561.
DR GeneID; 183212; -.
DR KEGG; cel:CELE_C34E10.7; -.
DR CTD; 183212; -.
DR WormBase; C34E10.7; CE01187; WBGene00000561; cnd-1.
DR eggNOG; KOG3898; Eukaryota.
DR HOGENOM; CLU_101906_0_0_1; -.
DR InParanoid; P46581; -.
DR OMA; QYYYSPN; -.
DR OrthoDB; 1518504at2759; -.
DR PhylomeDB; P46581; -.
DR PRO; PR:P46581; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000561; Expressed in embryo and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007413; P:axonal fasciculation; IMP:WormBase.
DR GO; GO:0014014; P:negative regulation of gliogenesis; IMP:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR022575; Neurogenic_DUF.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF12533; Neuro_bHLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..192
FT /note="Neurogenic differentiation factor 1"
FT /id="PRO_0000127508"
FT DOMAIN 19..71
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 116..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 192 AA; 21845 MW; B1BCFEAF6C7310F1 CRC64;
MRPTDTSNFA PAEISKRKVR RVKANGRERA RMHGLNNALD MLREYIPITT QHQKLSKIET
LRLARNYIDA LQRMLQTNEQ PTPLEYAHTL ANGLSQTTTN MLANLLQVQP RQLLPPSQFD
IFSDPSHHQL HPSHPPPHSS FSSSSPSSSC SPPQYYYSPT QPSAAPLQGS CDPQYQQMYH
QHSHQNTFNY SP
