NDF1_CHICK
ID NDF1_CHICK Reviewed; 357 AA.
AC P79765; O73826;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Neurogenic differentiation factor 1;
DE Short=NeuroD;
DE Short=NeuroD1;
GN Name=NEUROD1; Synonyms=NEUROD;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=White leghorn; TISSUE=Retina;
RX PubMed=9310321; DOI=10.1242/dev.124.17.3263;
RA Roztocil T., Matter-Sadzinski L., Alliod C., Ballivet M., Matter J.-M.;
RT "NeuroM, a neural helix-loop-helix transcription factor, defines a new
RT transition stage in neurogenesis.";
RL Development 124:3263-3272(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=White leghorn; TISSUE=Brain;
RX PubMed=9740021;
RX DOI=10.1002/(sici)1097-4695(19980915)36:4<485::aid-neu3>3.0.co;2-s;
RA Yan R.-T., Wang S.-Z.;
RT "NeuroD induces photoreceptor cell overproduction in vivo and de novo
RT generation in vitro.";
RL J. Neurobiol. 36:485-496(1998).
CC -!- FUNCTION: Acts as a transcriptional activator that mediates
CC transcriptional activation by binding to E box-containing promoter (5'-
CC CANNTG-3') (PubMed:9310321, PubMed:9740021). Acts as a differentiation
CC factor during neurogenesis (PubMed:9310321). Induces photoreceptor cell
CC overproduction in vivo and de novo generation in vitro
CC (PubMed:9740021). May play a role in photoreceptor cell production
CC (PubMed:9740021). {ECO:0000269|PubMed:9310321,
CC ECO:0000269|PubMed:9740021}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. {ECO:0000250|UniProtKB:Q60867}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- DEVELOPMENTAL STAGE: In the spinal cord it is found in neurons that are
CC migrating or have reached their final position. Expressed in cells
CC located at the outer portion of the developing retinal neuroepithelium,
CC the location where prospective photoreceptors reside.
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DR EMBL; Y09596; CAA70784.1; -; mRNA.
DR EMBL; AF060885; AAC79425.1; -; mRNA.
DR RefSeq; NP_990251.1; NM_204920.1.
DR AlphaFoldDB; P79765; -.
DR SMR; P79765; -.
DR STRING; 9031.ENSGALP00000014468; -.
DR PaxDb; P79765; -.
DR GeneID; 395754; -.
DR KEGG; gga:395754; -.
DR CTD; 4760; -.
DR VEuPathDB; HostDB:geneid_395754; -.
DR eggNOG; KOG3898; Eukaryota.
DR InParanoid; P79765; -.
DR OrthoDB; 1096531at2759; -.
DR PhylomeDB; P79765; -.
DR PRO; PR:P79765; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048666; P:neuron development; IEA:InterPro.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0042479; P:positive regulation of eye photoreceptor cell development; IDA:CACAO.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR032652; Neurod1.
DR InterPro; IPR022575; Neurogenic_DUF.
DR InterPro; IPR016637; TF_bHLH_NeuroD.
DR PANTHER; PTHR19290:SF88; PTHR19290:SF88; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF12533; Neuro_bHLH; 1.
DR PIRSF; PIRSF015618; bHLH_NeuroD; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Activator; Cytoplasm; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..357
FT /note="Neurogenic differentiation factor 1"
FT /id="PRO_0000127385"
FT DOMAIN 104..156
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 90..96
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 33..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..79
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 282
FT /note="N -> Y (in Ref. 2; AAC79425)"
FT /evidence="ECO:0000305"
FT CONFLICT 297
FT /note="K -> N (in Ref. 2; AAC79425)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="G -> A (in Ref. 2; AAC79425)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 357 AA; 38809 MW; 770649CF9DDC54F6 CRC64;
MTKSYSESGP AGEPQAQAPP GWAAGCLSPP ADGPEADKKE EDLEALHGEA EEDALRNGEE
EDEEDELDEE EEEEEEEEDD EQKPKRRGPK KKKMTKARLE RFKLRRMKAN ARERNRMHGL
NAALDNLRKV VPCYSKTQKL SKIETLRLAK NYIWALSEIL RSGKSPDLVS FVQTLCKGLS
QPTTNLVAGC LQLNPRTFLP EQSADAAPHL PPAGAPFAPP PFPYASPGLP SPPYGTMDSS
HLFHLKPPHA YGAALEPFFE GGLPEGAGPA FDGPLSPPLS INGNFSFKHE PAADFDKSYA
FTMHYPAGPL PAAPAHAAVF SGAAARCELP GDGLAPYEGH PHHERVLSAQ LSAIFHE
