NDF2_DANRE
ID NDF2_DANRE Reviewed; 363 AA.
AC Q9W6C8;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Neurogenic differentiation factor 2;
DE Short=NeuroD2;
GN Name=neurod2 {ECO:0000312|ZFIN:ZDB-GENE-010608-3};
GN Synonyms=ndr2 {ECO:0000312|EMBL:AAD23443.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAD23443.1}
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo {ECO:0000269|PubMed:10235116};
RX PubMed=10235116; DOI=10.1089/104454999315394;
RA Liao J., He J., Yan T., Korzh V., Gong Z.;
RT "A class of neuroD-related basic helix-loop-helix transcription factors
RT expressed in developing central nervous system in zebrafish.";
RL DNA Cell Biol. 18:333-344(1999).
CC -!- FUNCTION: Transcriptional regulator. Appears to mediate neuronal
CC differentiation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. {ECO:0000250|UniProtKB:Q15784}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: In adult, expressed strongly in brain and more
CC weakly in skin, muscle, eye and ovary. {ECO:0000269|PubMed:10235116}.
CC -!- DEVELOPMENTAL STAGE: Embryonic, larval and adult stages. Expression is
CC weak from 10 to 48 hours post-fertilization (hpf) and increases from 72
CC hpf. {ECO:0000269|PubMed:10235116}.
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DR EMBL; AF115774; AAD23443.1; -; mRNA.
DR RefSeq; NP_571157.1; NM_131082.1.
DR AlphaFoldDB; Q9W6C8; -.
DR STRING; 7955.ENSDARP00000023642; -.
DR PaxDb; Q9W6C8; -.
DR GeneID; 114435; -.
DR KEGG; dre:114435; -.
DR CTD; 4761; -.
DR ZFIN; ZDB-GENE-010608-3; neurod2.
DR eggNOG; KOG3898; Eukaryota.
DR InParanoid; Q9W6C8; -.
DR OrthoDB; 1096531at2759; -.
DR PhylomeDB; Q9W6C8; -.
DR PRO; PR:Q9W6C8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0045664; P:regulation of neuron differentiation; IEA:InterPro.
DR GO; GO:0090128; P:regulation of synapse maturation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR032649; Neurod2.
DR InterPro; IPR022575; Neurogenic_DUF.
DR InterPro; IPR016637; TF_bHLH_NeuroD.
DR PANTHER; PTHR19290:SF83; PTHR19290:SF83; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF12533; Neuro_bHLH; 1.
DR PIRSF; PIRSF015618; bHLH_NeuroD; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..363
FT /note="Neurogenic differentiation factor 2"
FT /id="PRO_0000274818"
FT DOMAIN 107..159
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 93..99
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 24..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..81
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 363 AA; 40605 MW; 76AB635CA2CC373E CRC64;
MLTRLFKEPS LLPDMQKFGG WVDDSGSEDS KTKDEEQERC RLGDEDLDEG SVKGGGSRAQ
SEIAGEEDYD EDVDEDDCGE EGDGDRPKKR GPKKRKMTPA RLERSKVRRQ KANARERTRM
HDLNSALDNL LKVVPCYSKT QKLSKIETLR LAKNYIWALS EILRNGKRPD VVSYVQTLCK
GLSQPTTNLV AGCLQLNSRN FLTEQCQEGV RFHTPTPSFS IQSYPYQCSR LSSTNCQSGS
STHSLRNHSL CSAYEALYTE GTSPEYISAD FEGHHGPPVC VNGNFGVRQE EPLSPDAERG
YQYSMHYTNL HGSRSSAAHG ITCGPPGARS GSVHSENLPL FHDVHMHHDR TPAYEELNAF
FHS
