NDF6A_DANRE
ID NDF6A_DANRE Reviewed; 327 AA.
AC Q6NYU3; Q9W6C6;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Neurogenic differentiation factor 6-A;
DE Short=NeuroD6-A;
DE AltName: Full=Protein atonal homolog 2-A;
GN Name=neurod6a {ECO:0000250|UniProtKB:Q96NK8};
GN Synonyms=atoh2a {ECO:0000312|ZFIN:ZDB-GENE-010608-1},
GN ndr1a {ECO:0000312|EMBL:AAD23441.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAD23441.1}
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo {ECO:0000269|PubMed:10235116};
RX PubMed=10235116; DOI=10.1089/104454999315394;
RA Liao J., He J., Yan T., Korzh V., Gong Z.;
RT "A class of neuroD-related basic helix-loop-helix transcription factors
RT expressed in developing central nervous system in zebrafish.";
RL DNA Cell Biol. 18:333-344(1999).
RN [2] {ECO:0000312|EMBL:AAH66459.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH66459.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP FUNCTION.
RX PubMed=12044886; DOI=10.1016/s0014-5793(02)02809-0;
RA Wang X., Korzh V., Gong Z.;
RT "The functional specificity of NeuroD is defined by a single amino acid
RT residue (N11) in the basic domain.";
RL FEBS Lett. 520:139-144(2002).
CC -!- FUNCTION: Differentiation factor required for neurogenesis. Acts as an
CC upstream activator of isl1. {ECO:0000269|PubMed:12044886}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. {ECO:0000250|UniProtKB:P48986}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Embryonic olfactory bulbs. In adult, expressed in
CC brain, eye, intestine, muscle, ovary and skin.
CC {ECO:0000269|PubMed:10235116}.
CC -!- DEVELOPMENTAL STAGE: Embryonic, larval and adult stages. First detected
CC at 22 hours post-fertilization (hpf). {ECO:0000269|PubMed:10235116}.
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DR EMBL; AF115772; AAD23441.1; -; mRNA.
DR EMBL; BC066459; AAH66459.1; -; mRNA.
DR RefSeq; NP_571891.3; NM_131816.3.
DR AlphaFoldDB; Q6NYU3; -.
DR SMR; Q6NYU3; -.
DR STRING; 7955.ENSDARP00000089629; -.
DR PaxDb; Q6NYU3; -.
DR Ensembl; ENSDART00000058530; ENSDARP00000096474; ENSDARG00000040008.
DR Ensembl; ENSDART00000098859; ENSDARP00000089629; ENSDARG00000040008.
DR GeneID; 114414; -.
DR KEGG; dre:114414; -.
DR CTD; 114414; -.
DR ZFIN; ZDB-GENE-010608-1; neurod6a.
DR eggNOG; KOG3898; Eukaryota.
DR GeneTree; ENSGT00940000159827; -.
DR HOGENOM; CLU_055134_1_0_1; -.
DR InParanoid; Q6NYU3; -.
DR OMA; YSYCSAY; -.
DR PhylomeDB; Q6NYU3; -.
DR PRO; PR:Q6NYU3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 24.
DR Bgee; ENSDARG00000040008; Expressed in brain and 13 other tissues.
DR ExpressionAtlas; Q6NYU3; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR032650; Neurod6.
DR InterPro; IPR022575; Neurogenic_DUF.
DR InterPro; IPR016637; TF_bHLH_NeuroD.
DR PANTHER; PTHR19290:SF9; PTHR19290:SF9; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF12533; Neuro_bHLH; 1.
DR PIRSF; PIRSF015618; bHLH_NeuroD; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..327
FT /note="Neurogenic differentiation factor 6-A"
FT /id="PRO_0000274815"
FT DOMAIN 88..140
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 17..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 74..80
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 27..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 247
FT /note="S -> T (in Ref. 1; AAD23441)"
FT /evidence="ECO:0000305"
FT CONFLICT 285..298
FT /note="CAVPPRASIGQSAR -> WRSAAFHRPEPA (in Ref. 1;
FT AAD23441)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 327 AA; 36949 MW; 117D88AB574380FF CRC64;
MLTLPFEDPV IMDTQFGANF PRDCVGDLKG NKQEPFEKEE TLSHVMDDDD SEKDEDERED
GQDENGLPRR RGPRKKKMTK ARVDRVKVRR MEANARERNR MHGLNNALDS LRKVVPCYSK
TQKLSKIETL RLAKNYIWAL SEILSTGKRP DLLTFVQTLC KGLSQPTTNL VAGCLQLNAR
NFIPDQISGE ASFSGRSPYE SVYSTYHSPS VVTPSGPSVD AVKPFRSFNY CSSYESFYES
VSPECGSPQF EGPLSPPINF NGIFSLKHEE PVEYGKSCHY GTRYCAVPPR ASIGQSARGS
SDLHFPYDIH LRGQFYPVQD ELNTFHN
