ID   NDF6_BOVIN              Reviewed;         337 AA.
AC   Q08DI0;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Neurogenic differentiation factor 6;
DE            Short=NeuroD6;
GN   Name=NEUROD6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Activates E box-dependent transcription in collaboration with
CC       TCF3/E47. May be a trans-acting factor involved in the development and
CC       maintenance of the mammalian nervous system. Transactivates the
CC       promoter of its own gene (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; BC123740; AAI23741.1; -; mRNA.
DR   RefSeq; NP_001069689.1; NM_001076221.1.
DR   AlphaFoldDB; Q08DI0; -.
DR   SMR; Q08DI0; -.
DR   STRING; 9913.ENSBTAP00000000728; -.
DR   PaxDb; Q08DI0; -.
DR   Ensembl; ENSBTAT00000000728; ENSBTAP00000000728; ENSBTAG00000000558.
DR   GeneID; 540464; -.
DR   KEGG; bta:540464; -.
DR   CTD; 63974; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000558; -.
DR   VGNC; VGNC:32020; NEUROD6.
DR   eggNOG; KOG3898; Eukaryota.
DR   GeneTree; ENSGT00940000159827; -.
DR   HOGENOM; CLU_055134_1_0_1; -.
DR   InParanoid; Q08DI0; -.
DR   OMA; ANYPRES; -.
DR   OrthoDB; 1096531at2759; -.
DR   TreeFam; TF315153; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000000558; Expressed in Ammon's horn and 10 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0021542; P:dentate gyrus development; IEA:Ensembl.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR032650; Neurod6.
DR   InterPro; IPR022575; Neurogenic_DUF.
DR   InterPro; IPR016637; TF_bHLH_NeuroD.
DR   PANTHER; PTHR19290:SF9; PTHR19290:SF9; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF12533; Neuro_bHLH; 1.
DR   PIRSF; PIRSF015618; bHLH_NeuroD; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..337
FT                   /note="Neurogenic differentiation factor 6"
FT                   /id="PRO_0000279744"
FT   DOMAIN          94..146
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          43..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           80..86
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   337 AA;  38673 MW;  6B15F0871CA5818E CRC64;
     MLTLPFDESV VMPESQMCRK FSRECEDQKQ IKKPESFSKQ IVLRGKSIKR APGEETEKEE
     EEEDREEEDE NGLPRRRGLR KKKTTKLRLE RVKFRRQEAN ARERNRMHGL NDALDNLRKV
     VPCYSKTQKL SKIETLRLAK NYIWALSEIL RIGKRPDLLT FVQNLCKGLS QPTTNLVAGC
     LQLNARSFLV GQGGEAAHHT RSPYSTFYPP YHSPELTTPP GHGTLDNSKS MKPYNYCSAY
     ESFYESTSPE CASPQFEGPL SPPPINYNGI FSLKQEETLD YGKNYNYGMH YCAVPPRGPL
     GQGAMFRLPT DSHFPYDLHL RSQSLTMQDE LNAVFHN