NDF6_MOUSE
ID NDF6_MOUSE Reviewed; 337 AA.
AC P48986;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Neurogenic differentiation factor 6;
DE Short=NeuroD6;
DE AltName: Full=Helix-loop-helix protein mATH-2;
DE Short=mATH2;
DE AltName: Full=Protein NEX-1;
DE AltName: Full=Protein atonal homolog 2;
GN Name=Neurod6; Synonyms=Ath2, Atoh2, Nex1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/J;
RX PubMed=7744035; DOI=10.1111/j.1432-1033.1995.tb20461.x;
RA Shimizu C., Akazawa C., Nakanishi S., Kageyama R.;
RT "MATH-2, a mammalian helix-loop-helix factor structurally related to the
RT product of Drosophila proneural gene atonal, is specifically expressed in
RT the nervous system.";
RL Eur. J. Biochem. 229:239-248(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=7545978; DOI=10.1016/0925-4773(94)90061-2;
RA Bartholomae A., Nave K.-A.;
RT "NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation
RT and sustained expression in mature cortical neurons.";
RL Mech. Dev. 48:217-228(1994).
CC -!- FUNCTION: Activates E box-dependent transcription in collaboration with
CC TCF3/E47. May be a trans-acting factor involved in the development and
CC maintenance of the mammalian nervous system. Transactivates the
CC promoter of its own gene.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Specific to the nervous system of both embryos and
CC adults. Highest levels in the cortical plate of the cerebrum.
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DR EMBL; D44480; BAA07923.1; -; Genomic_DNA.
DR EMBL; U29086; AAC14576.1; -; mRNA.
DR CCDS; CCDS20168.1; -.
DR PIR; I48682; I48682.
DR PIR; I57038; I57038.
DR RefSeq; NP_033847.1; NM_009717.2.
DR AlphaFoldDB; P48986; -.
DR SMR; P48986; -.
DR STRING; 10090.ENSMUSP00000047016; -.
DR PhosphoSitePlus; P48986; -.
DR PaxDb; P48986; -.
DR PRIDE; P48986; -.
DR ProteomicsDB; 293534; -.
DR Antibodypedia; 12707; 193 antibodies from 30 providers.
DR DNASU; 11922; -.
DR Ensembl; ENSMUST00000044767; ENSMUSP00000047016; ENSMUSG00000037984.
DR GeneID; 11922; -.
DR KEGG; mmu:11922; -.
DR UCSC; uc009cav.2; mouse.
DR CTD; 63974; -.
DR MGI; MGI:106593; Neurod6.
DR VEuPathDB; HostDB:ENSMUSG00000037984; -.
DR eggNOG; KOG3898; Eukaryota.
DR GeneTree; ENSGT00940000159827; -.
DR HOGENOM; CLU_055134_1_0_1; -.
DR InParanoid; P48986; -.
DR OMA; ANYPRES; -.
DR OrthoDB; 1096531at2759; -.
DR PhylomeDB; P48986; -.
DR TreeFam; TF315153; -.
DR BioGRID-ORCS; 11922; 1 hit in 72 CRISPR screens.
DR PRO; PR:P48986; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P48986; protein.
DR Bgee; ENSMUSG00000037984; Expressed in cortical plate and 98 other tissues.
DR ExpressionAtlas; P48986; baseline and differential.
DR Genevisible; P48986; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0021542; P:dentate gyrus development; IGI:MGI.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR032650; Neurod6.
DR InterPro; IPR022575; Neurogenic_DUF.
DR InterPro; IPR016637; TF_bHLH_NeuroD.
DR PANTHER; PTHR19290:SF9; PTHR19290:SF9; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF12533; Neuro_bHLH; 1.
DR PIRSF; PIRSF015618; bHLH_NeuroD; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..337
FT /note="Neurogenic differentiation factor 6"
FT /id="PRO_0000127394"
FT DOMAIN 94..146
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 28..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 80..86
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 337 AA; 38644 MW; 35C18ACD8EE1EFBA CRC64;
MLTLPFDESV VMPESQMCRK FARQCEDQKQ IKKPESFPKQ VVLRGKSIKR APGEETEKEE
EEEDREEEDE NGLSRRRGLR KKKTTKLRLE RVKFRRQEAN ARERNRMHGL NDALDNLRKV
VPCYSKTQKL SKIETLRLAK NYIWALSEIL RIGKRPDLLT FVQNLCKGLS QPTTNLVAGC
LQLNARSFLM GQGGEAAHHT RSPYSTFYPP YHSPELATPP GHGTLDNSKS MKPYNYCSAY
ESFYESTSPE CASPQFEGPL SPPPINYNGI FSLKQEETLD YGKNYNYGMH YCAVPPRGPL
GQGAMFRLPT DSHFPYDLHL RSQSLTMQDE LNAVFHN
