NDH1_SCHPO
ID NDH1_SCHPO Reviewed; 551 AA.
AC O14121;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Probable NADH-ubiquinone oxidoreductase C3A11.07, mitochondrial;
DE EC=1.6.5.9;
DE Flags: Precursor;
GN ORFNames=SPAC3A11.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Catalyzes the oxidation of NADH. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + H(+) + NADH = a quinol + NAD(+);
CC Xref=Rhea:RHEA:46160, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; EC=1.6.5.9;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + H(+) + NADH = a ubiquinol + NAD(+);
CC Xref=Rhea:RHEA:23152, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the NADH dehydrogenase family. {ECO:0000305}.
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DR EMBL; CU329670; CAB16382.1; -; Genomic_DNA.
DR PIR; T11629; T11629.
DR RefSeq; NP_594196.1; NM_001019620.2.
DR AlphaFoldDB; O14121; -.
DR SMR; O14121; -.
DR BioGRID; 279551; 21.
DR STRING; 4896.SPAC3A11.07.1; -.
DR iPTMnet; O14121; -.
DR MaxQB; O14121; -.
DR PaxDb; O14121; -.
DR PRIDE; O14121; -.
DR EnsemblFungi; SPAC3A11.07.1; SPAC3A11.07.1:pep; SPAC3A11.07.
DR GeneID; 2543119; -.
DR KEGG; spo:SPAC3A11.07; -.
DR PomBase; SPAC3A11.07; -.
DR VEuPathDB; FungiDB:SPAC3A11.07; -.
DR eggNOG; KOG2495; Eukaryota.
DR HOGENOM; CLU_021377_1_0_1; -.
DR InParanoid; O14121; -.
DR OMA; VDPRSYM; -.
DR PhylomeDB; O14121; -.
DR PRO; PR:O14121; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0031966; C:mitochondrial membrane; ISO:PomBase.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0050136; F:NADH dehydrogenase (quinone) activity; IEA:RHEA.
DR GO; GO:0019655; P:glycolytic fermentation to ethanol; ISO:PomBase.
DR GO; GO:0006116; P:NADH oxidation; ISS:PomBase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR045024; NDH-2.
DR PANTHER; PTHR43706; PTHR43706; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR SUPFAM; SSF51905; SSF51905; 2.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Mitochondrion; NAD; Oxidoreductase; Reference proteome;
KW Transit peptide; Ubiquinone.
FT TRANSIT 1..37
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 38..551
FT /note="Probable NADH-ubiquinone oxidoreductase C3A11.07,
FT mitochondrial"
FT /id="PRO_0000337257"
FT BINDING 93..123
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000250"
FT BINDING 255..291
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
SQ SEQUENCE 551 AA; 61675 MW; FED02DB71DEB9281 CRC64;
MLFSRSILRG MPKAGIPKSP LALSASRNLR LANSVRFASD AASSPKSTTS KWKILKRTTL
GLFATAVVLY GANVYRFRHP DPHQPLPDPS KKTLVVLGAG WGATSILRTI DTSLFNVIVV
SPRNYFLFTS LLPSTATGSV HTRSIVQPIR YMLRHKSCYV KFYEAECTDV DADKKVIHIK
KTTTDGVDLE QEIKYDYLVC SHGAETQTFN IPGIAEYGCF LKEIWDAQKI RARILHCLEQ
AQFKDLPAET RRRYVHTVVV GGGPTGMEFA GEMADFIEDD LKSWYPELAD DFAVTLVEAL
PSVLPMFSAK LRDYTQSLFD SSHIKIRTNT ALKKVTAENI HVEVKNPDGS KQEEVIPYGL
LVWAGGNRAR PLTKKLMEGS EEQNNRRGLV VDEYLKLKGY KDIFALGDCT HTAYAPTAQV
ASQQGAYLGQ LFNKLGSLNF EKPSEDRHIA LGDEMDSSTL ISLANEKHAS TKVFLPFKYS
HQGSLAYVGH EKAIADIEVP WFGKQLHASG ALAFYFWRSV YLSELYSLRN RTNVTLDWIR
VKLFGRDISS L
