ID   AROC_SCHPO              Reviewed;         395 AA.
AC   O74413; Q9Y7Q4;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 2.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Chorismate synthase;
DE            EC=4.2.3.5;
DE   AltName: Full=5-enolpyruvylshikimate-3-phosphate phospholyase;
GN   ORFNames=SPCC1223.14, SPCC297.01;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate +
CC         phosphate; Xref=Rhea:RHEA:21020, ChEBI:CHEBI:29748,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57701; EC=4.2.3.5;
CC   -!- COFACTOR:
CC       Name=FMNH2; Xref=ChEBI:CHEBI:57618; Evidence={ECO:0000250};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       7/7.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chorismate synthase family. {ECO:0000305}.
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DR   EMBL; CU329672; CAA20883.1; -; Genomic_DNA.
DR   PIR; T41268; T41268.
DR   RefSeq; NP_588359.2; NM_001023350.2.
DR   AlphaFoldDB; O74413; -.
DR   SMR; O74413; -.
DR   STRING; 4896.SPCC1223.14.1; -.
DR   iPTMnet; O74413; -.
DR   MaxQB; O74413; -.
DR   PaxDb; O74413; -.
DR   PRIDE; O74413; -.
DR   EnsemblFungi; SPCC1223.14.1; SPCC1223.14.1:pep; SPCC1223.14.
DR   GeneID; 2538817; -.
DR   KEGG; spo:SPCC1223.14; -.
DR   PomBase; SPCC1223.14; -.
DR   VEuPathDB; FungiDB:SPCC1223.14; -.
DR   eggNOG; KOG4492; Eukaryota.
DR   HOGENOM; CLU_034547_0_1_1; -.
DR   InParanoid; O74413; -.
DR   OMA; MLSINAV; -.
DR   PhylomeDB; O74413; -.
DR   UniPathway; UPA00053; UER00090.
DR   PRO; PR:O74413; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0004107; F:chorismate synthase activity; ISO:PomBase.
DR   GO; GO:0010181; F:FMN binding; IBA:GO_Central.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IBA:GO_Central.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IBA:GO_Central.
DR   CDD; cd07304; Chorismate_synthase; 1.
DR   Gene3D; 3.60.150.10; -; 1.
DR   HAMAP; MF_00300; Chorismate_synth; 1.
DR   InterPro; IPR000453; Chorismate_synth.
DR   InterPro; IPR035904; Chorismate_synth_AroC_sf.
DR   InterPro; IPR020541; Chorismate_synthase_CS.
DR   PANTHER; PTHR21085; PTHR21085; 1.
DR   Pfam; PF01264; Chorismate_synt; 1.
DR   PIRSF; PIRSF001456; Chorismate_synth; 1.
DR   SUPFAM; SSF103263; SSF103263; 1.
DR   TIGRFAMs; TIGR00033; aroC; 1.
DR   PROSITE; PS00787; CHORISMATE_SYNTHASE_1; 1.
DR   PROSITE; PS00788; CHORISMATE_SYNTHASE_2; 1.
DR   PROSITE; PS00789; CHORISMATE_SYNTHASE_3; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Lyase;
KW   Reference proteome.
FT   CHAIN           1..395
FT                   /note="Chorismate synthase"
FT                   /id="PRO_0000140703"
SQ   SEQUENCE   395 AA;  42325 MW;  B551505160696DE5 CRC64;
     MSSFGTLFKV TTYGESHCKS VGCIVEGCPP GMNLTESDVQ VQLTRRRPGQ SNLTTPRNEK
     DKVQIQSGTE FGVTLGTPIG MLVLNQDQKP HDYSDMDNYP RPSHADYTYL EKYGVKASSG
     GGRSSARETI GRVAAGAIAE KYLLEAYGVE IVAFVSSVGK IAIPLHETAS SAILDPEDDT
     FESPITAEYL KFLNKITREE VDKTTVRCPH AATAAKMAER ITRARDNHDS IGGTVTCVIR
     NVPTGLGEPC FDKLEAKLAH AMMSIPATKS FEIGSGREGC KVAGSKHNDL FYRNADTGKL
     GTLTNNSGGV QGGISNGENV YFTIGFKSPA TIGVEQSTSR YDGSDGVLAA KGRHDPCVVP
     RAIPIVEAMA ALVVMDAVMI QQSRIASRNL LPNAQ