ID   A1AG_BOVIN              Reviewed;         202 AA.
AC   Q3SZR3;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Alpha-1-acid glycoprotein;
DE   AltName: Full=Orosomucoid;
DE            Short=OMD;
DE   Flags: Precursor;
GN   Name=ORM1; Synonyms=AGP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as transport protein in the blood stream. Binds
CC       various ligands in the interior of its beta-barrel domain (By
CC       similarity). Appears to function in modulating the activity of the
CC       immune system during the acute-phase reaction (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: Contains a beta-barrel that binds various ligands in its
CC       interior. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; BC102740; AAI02741.1; -; mRNA.
DR   RefSeq; NP_001035592.1; NM_001040502.2.
DR   AlphaFoldDB; Q3SZR3; -.
DR   SMR; Q3SZR3; -.
DR   STRING; 9913.ENSBTAP00000022991; -.
DR   GlyConnect; 16; 27 N-Linked glycans (2 sites).
DR   PaxDb; Q3SZR3; -.
DR   PeptideAtlas; Q3SZR3; -.
DR   PRIDE; Q3SZR3; -.
DR   GeneID; 497200; -.
DR   KEGG; bta:497200; -.
DR   CTD; 5004; -.
DR   eggNOG; ENOG502S0Q2; Eukaryota.
DR   InParanoid; Q3SZR3; -.
DR   OrthoDB; 1257041at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   GO; GO:0002682; P:regulation of immune system process; IEA:InterPro.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR001500; A1A_glycop.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PIRSF; PIRSF036899; AGP; 1.
DR   PRINTS; PR00708; A1AGLPROTEIN.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   2: Evidence at transcript level;
KW   Acute phase; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Signal; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250"
FT   CHAIN           19..202
FT                   /note="Alpha-1-acid glycoprotein"
FT                   /id="PRO_0000271395"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        57
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        136
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        91..184
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   202 AA;  23182 MW;  B6EF3A1691BCCF2F CRC64;
     MALLWALAVL SHLPLLDAQS PECANLMTVA PITNATMDLL SGKWFYIGSA FRNPEYNKSA
     RAIQAAFFYL EPRHAEDKLI TREYQTIEDK CVYNCSFIKI YRQNGTLSKV ESDREHFVDL
     LLSKHFRTFM LAASWNGTKN VGVSFYADKP EVTQEQKKEF LDVIKCIGIQ ESEIIYTDEK
     KDACGPLEKQ HEEERKKETE AS