NDJ1_YEAST
ID NDJ1_YEAST Reviewed; 352 AA.
AC Q12366; D6W1W2;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Non-disjunction protein 1;
DE AltName: Full=Telomere-associated meiosis protein 1;
GN Name=NDJ1; Synonyms=TAM1; OrderedLocusNames=YOL104C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7502582; DOI=10.1002/yea.320111108;
RA Vandenbol M., Durand P., Portetelle D., Hilger F.;
RT "Sequence analysis of a 44 kb DNA fragment of yeast chromosome XV including
RT the Ty1-H3 retrotransposon, the suf1(+) frameshift suppressor gene for
RT tRNA-Gly, the yeast transfer RNA-Thr-1a and a delta element.";
RL Yeast 11:1069-1075(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=9242487; DOI=10.1101/gad.11.14.1786;
RA Chua P.R., Roeder G.S.;
RT "Tam1, a telomere-associated meiotic protein, functions in chromosome
RT synapsis and crossover interference.";
RL Genes Dev. 11:1786-1800(1997).
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=9157883; DOI=10.1126/science.276.5316.1252;
RA Conrad M.N., Dominguez A.M., Dresser M.E.;
RT "Ndj1p, a meiotic telomere protein required for normal chromosome synapsis
RT and segregation in yeast.";
RL Science 276:1252-1255(1997).
RN [7]
RP FUNCTION.
RX PubMed=9716409; DOI=10.1101/gad.12.16.2574;
RA Rockmill B., Roeder G.S.;
RT "Telomere-mediated chromosome pairing during meiosis in budding yeast.";
RL Genes Dev. 12:2574-2586(1998).
RN [8]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11018056; DOI=10.1083/jcb.151.1.95;
RA Trelles-Sticken E., Dresser M.E., Scherthan H.;
RT "Meiotic telomere protein Ndj1p is required for meiosis-specific telomere
RT distribution, bouquet formation and efficient homologue pairing.";
RL J. Cell Biol. 151:95-106(2000).
RN [9]
RP FUNCTION.
RX PubMed=10944222; DOI=10.1073/pnas.97.17.9537;
RA Goldman A.S.H., Lichten M.;
RT "Restriction of ectopic recombination by interhomolog interactions during
RT Saccharomyces cerevisiae meiosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9537-9542(2000).
RN [10]
RP FUNCTION.
RX PubMed=15579679; DOI=10.1534/genetics.104.029157;
RA Schlecht H.B., Lichten M., Goldman A.S.H.;
RT "Compartmentalization of the yeast meiotic nucleus revealed by analysis of
RT ectopic recombination.";
RL Genetics 168:1189-1203(2004).
RN [11]
RP FUNCTION.
RX PubMed=15694306; DOI=10.1016/j.cub.2005.01.039;
RA Joseph I., Jia D., Lustig A.J.;
RT "Ndj1p-dependent epigenetic resetting of telomere size in yeast meiosis.";
RL Curr. Biol. 15:231-237(2005).
RN [12]
RP SUBCELLULAR LOCATION.
RX PubMed=16254243; DOI=10.1242/jcs.02612;
RA Trelles-Sticken E., Bonfils S., Sollier J., Geli V., Scherthan H.,
RA de La Roche Saint-Andre C.;
RT "Set1- and Clb5-deficiencies disclose the differential regulation of
RT centromere and telomere dynamics in Saccharomyces cerevisiae meiosis.";
RL J. Cell Sci. 118:4985-4994(2005).
RN [13]
RP FUNCTION.
RX PubMed=16648465; DOI=10.1128/mcb.26.10.3683-3694.2006;
RA Wu H.-Y., Burgess S.M.;
RT "Ndj1, a telomere-associated protein, promotes meiotic recombination in
RT budding yeast.";
RL Mol. Cell. Biol. 26:3683-3694(2006).
RN [14]
RP FUNCTION, AND INTERACTION WITH MPS3.
RX PubMed=17495028; DOI=10.1073/pnas.0606165104;
RA Conrad M.N., Lee C.Y., Wilkerson J.L., Dresser M.E.;
RT "MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiae.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8863-8868(2007).
RN [15]
RP FUNCTION, AND INTERACTION WITH MPS3.
RX PubMed=18585352; DOI=10.1016/j.cell.2008.04.047;
RA Conrad M.N., Lee C.Y., Chao G., Shinohara M., Kosaka H., Shinohara A.,
RA Conchello J.A., Dresser M.E.;
RT "Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and
RT CSM4 and is modulated by recombination.";
RL Cell 133:1175-1187(2008).
CC -!- FUNCTION: Required for telomeric clustering (bouquet stage) during
CC meiosis 1 prophase, formation and efficient homolog pairing, meiosis 1
CC disjunction, and telomere deletion during meiosis. Promotes also
CC meiotic recombination. {ECO:0000269|PubMed:10944222,
CC ECO:0000269|PubMed:11018056, ECO:0000269|PubMed:15579679,
CC ECO:0000269|PubMed:15694306, ECO:0000269|PubMed:16648465,
CC ECO:0000269|PubMed:17495028, ECO:0000269|PubMed:18585352,
CC ECO:0000269|PubMed:9157883, ECO:0000269|PubMed:9242487,
CC ECO:0000269|PubMed:9716409}.
CC -!- SUBUNIT: Interacts with MPS3. {ECO:0000269|PubMed:17495028,
CC ECO:0000269|PubMed:18585352}.
CC -!- INTERACTION:
CC Q12366; P47069: MPS3; NbExp=2; IntAct=EBI-34568, EBI-25811;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11018056,
CC ECO:0000269|PubMed:16254243, ECO:0000269|PubMed:9157883,
CC ECO:0000269|PubMed:9242487}. Chromosome, telomere
CC {ECO:0000269|PubMed:11018056, ECO:0000269|PubMed:16254243,
CC ECO:0000269|PubMed:9157883, ECO:0000269|PubMed:9242487}.
CC -!- INDUCTION: During meiosis. {ECO:0000269|PubMed:9242487}.
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DR EMBL; Z48149; CAA88156.1; -; Genomic_DNA.
DR EMBL; Z74846; CAA99120.1; -; Genomic_DNA.
DR EMBL; AY693102; AAT93121.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10678.1; -; Genomic_DNA.
DR PIR; S51893; S51893.
DR RefSeq; NP_014537.1; NM_001183358.1.
DR AlphaFoldDB; Q12366; -.
DR BioGRID; 34297; 55.
DR DIP; DIP-4221N; -.
DR IntAct; Q12366; 1.
DR STRING; 4932.YOL104C; -.
DR iPTMnet; Q12366; -.
DR PaxDb; Q12366; -.
DR PRIDE; Q12366; -.
DR EnsemblFungi; YOL104C_mRNA; YOL104C; YOL104C.
DR GeneID; 854047; -.
DR KEGG; sce:YOL104C; -.
DR SGD; S000005464; NDJ1.
DR VEuPathDB; FungiDB:YOL104C; -.
DR eggNOG; ENOG502S4WZ; Eukaryota.
DR HOGENOM; CLU_861098_0_0_1; -.
DR InParanoid; Q12366; -.
DR OMA; CIIPRIC; -.
DR BioCyc; YEAST:G3O-33502-MON; -.
DR PRO; PR:Q12366; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q12366; protein.
DR GO; GO:0000781; C:chromosome, telomeric region; IDA:SGD.
DR GO; GO:0035974; C:meiotic spindle pole body; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042162; F:telomeric DNA binding; TAS:SGD.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IDA:SGD.
DR GO; GO:0070197; P:meiotic attachment of telomere to nuclear envelope; IMP:SGD.
DR GO; GO:0045141; P:meiotic telomere clustering; IDA:SGD.
DR GO; GO:2000711; P:positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric; IMP:SGD.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:SGD.
DR GO; GO:0010520; P:regulation of reciprocal meiotic recombination; IMP:SGD.
PE 1: Evidence at protein level;
KW Chromosome; Meiosis; Nucleus; Reference proteome; Telomere.
FT CHAIN 1..352
FT /note="Non-disjunction protein 1"
FT /id="PRO_0000268688"
SQ SEQUENCE 352 AA; 40856 MW; 87C1A7DF9AA8C077 CRC64;
MSKDNRLASI LLQPVASSSG NCTEFHDSKL HTLQEELNFL PLEGVASNVC PPMFRGHKNY
VFVLYCLNQV DLVTNLQDST KRYYPLQIFK DCQLSSLVQK DFSHYFQLSR QKEGEDRNDS
DTTLVNVVNS GVSRHRSQLL KMCIIPRICS FDKSNSKTYK LIQEYVNRFE TVLTKFGPEK
DFTKVYANWS KLIESFNELI LHDLLVKWQQ WSELTQPNAT VHQNIPNVLR ELVIKLTQRY
FTFQPSYSCS IDEFTTILLN KNALSLLDVF RKPRKYKLNF GLWLDCQNGI LIFTNGIVQM
ADEITSERVK SFVRPAHLLV LEDHSNDEAV KKLMFFTFSA ILQCFTDEIL NC
