NDK5_HUMAN
ID NDK5_HUMAN Reviewed; 212 AA.
AC P56597; B2R5G7;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 1.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Nucleoside diphosphate kinase homolog 5;
DE Short=NDK-H 5;
DE Short=NDP kinase homolog 5;
DE AltName: Full=Inhibitor of p53-induced apoptosis-beta;
DE Short=IPIA-beta;
DE AltName: Full=Testis-specific nm23 homolog;
DE AltName: Full=nm23-H5;
GN Name=NME5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Gall bladder;
RX PubMed=9742940; DOI=10.1016/s0014-5793(98)00996-x;
RA Munier A., Feral C., Milon L., Pinon V.P.-B., Gyapay G., Capeau J.,
RA Guellaen G., Lacombe M.-L.;
RT "A new human nm23 homologue (nm23-H5) specifically expressed in testis
RT germinal cells.";
RL FEBS Lett. 434:289-294(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RA Mehus J.G., Lambeth D.O.;
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Nakamura H., Tsuiki H., Sasaki J., Honda Y., Saya H.;
RT "Identification of a homolog of IPIA-alpha.";
RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Does not seem to have NDK kinase activity. Confers protection
CC from cell death by Bax and alters the cellular levels of several
CC antioxidant enzymes including Gpx5. May play a role in spermiogenesis
CC by increasing the ability of late-stage spermatids to eliminate
CC reactive oxygen species (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC P56597; P54253: ATXN1; NbExp=3; IntAct=EBI-740667, EBI-930964;
CC P56597; Q8WWB3: DYDC1; NbExp=8; IntAct=EBI-740667, EBI-740680;
CC P56597; Q96IM9: DYDC2; NbExp=3; IntAct=EBI-740667, EBI-749277;
CC P56597; P42858: HTT; NbExp=6; IntAct=EBI-740667, EBI-466029;
CC P56597; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-740667, EBI-1055254;
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q99MH5}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in testis germinal cells.
CC -!- SIMILARITY: Belongs to the NDK family. {ECO:0000305}.
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DR EMBL; Y14992; CAA75226.1; -; mRNA.
DR EMBL; AF067724; AAC64358.1; -; mRNA.
DR EMBL; U90450; AAC69440.1; -; mRNA.
DR EMBL; AK312181; BAG35114.1; -; mRNA.
DR EMBL; CH471062; EAW62164.1; -; Genomic_DNA.
DR EMBL; BC026182; AAH26182.1; -; mRNA.
DR CCDS; CCDS4197.1; -.
DR RefSeq; NP_003542.1; NM_003551.2.
DR AlphaFoldDB; P56597; -.
DR SMR; P56597; -.
DR BioGRID; 113972; 11.
DR IntAct; P56597; 6.
DR MINT; P56597; -.
DR STRING; 9606.ENSP00000265191; -.
DR iPTMnet; P56597; -.
DR PhosphoSitePlus; P56597; -.
DR BioMuta; NME5; -.
DR DMDM; 3914118; -.
DR MassIVE; P56597; -.
DR PaxDb; P56597; -.
DR PeptideAtlas; P56597; -.
DR PRIDE; P56597; -.
DR ProteomicsDB; 56930; -.
DR Antibodypedia; 26568; 184 antibodies from 25 providers.
DR DNASU; 8382; -.
DR Ensembl; ENST00000265191.4; ENSP00000265191.2; ENSG00000112981.5.
DR GeneID; 8382; -.
DR KEGG; hsa:8382; -.
DR MANE-Select; ENST00000265191.4; ENSP00000265191.2; NM_003551.3; NP_003542.1.
DR UCSC; uc003lce.4; human.
DR CTD; 8382; -.
DR DisGeNET; 8382; -.
DR GeneCards; NME5; -.
DR HGNC; HGNC:7853; NME5.
DR HPA; ENSG00000112981; Tissue enhanced (fallopian tube, testis).
DR MIM; 603575; gene.
DR neXtProt; NX_P56597; -.
DR OpenTargets; ENSG00000112981; -.
DR PharmGKB; PA31658; -.
DR VEuPathDB; HostDB:ENSG00000112981; -.
DR eggNOG; KOG0888; Eukaryota.
DR GeneTree; ENSGT00940000159595; -.
DR HOGENOM; CLU_060216_2_0_1; -.
DR InParanoid; P56597; -.
DR OMA; HNAISYW; -.
DR OrthoDB; 1473942at2759; -.
DR PhylomeDB; P56597; -.
DR TreeFam; TF354225; -.
DR PathwayCommons; P56597; -.
DR SignaLink; P56597; -.
DR BioGRID-ORCS; 8382; 14 hits in 1068 CRISPR screens.
DR ChiTaRS; NME5; human.
DR GenomeRNAi; 8382; -.
DR Pharos; P56597; Tbio.
DR PRO; PR:P56597; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; P56597; protein.
DR Bgee; ENSG00000112981; Expressed in bronchial epithelial cell and 146 other tissues.
DR ExpressionAtlas; P56597; baseline and differential.
DR Genevisible; P56597; HS.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0036126; C:sperm flagellum; IEA:Ensembl.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; TAS:ProtInc.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0003341; P:cilium movement; IBA:GO_Central.
DR GO; GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
DR GO; GO:1902176; P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0006165; P:nucleoside diphosphate phosphorylation; IEA:InterPro.
DR GO; GO:0009116; P:nucleoside metabolic process; TAS:ProtInc.
DR GO; GO:0007286; P:spermatid development; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; TAS:ProtInc.
DR GO; GO:0006228; P:UTP biosynthetic process; IEA:InterPro.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR Gene3D; 3.30.70.141; -; 1.
DR InterPro; IPR007858; Dpy-30_motif.
DR InterPro; IPR034907; NDK-like_dom.
DR InterPro; IPR036850; NDK-like_dom_sf.
DR InterPro; IPR012410; NDK_H5.
DR InterPro; IPR001564; Nucleoside_diP_kinase.
DR Pfam; PF05186; Dpy-30; 1.
DR Pfam; PF00334; NDK; 1.
DR PIRSF; PIRSF036504; NDK_H5; 1.
DR PRINTS; PR01243; NUCDPKINASE.
DR SMART; SM00562; NDK; 1.
DR SUPFAM; SSF54919; SSF54919; 1.
PE 1: Evidence at protein level;
KW Cell projection; Developmental protein; Differentiation;
KW Reference proteome; Spermatogenesis.
FT CHAIN 1..212
FT /note="Nucleoside diphosphate kinase homolog 5"
FT /id="PRO_0000137125"
FT ACT_SITE 127
FT /note="Pros-phosphohistidine intermediate"
FT /evidence="ECO:0000255"
SQ SEQUENCE 212 AA; 24236 MW; 9D37CD80338159A1 CRC64;
MEISMPPPQI YVEKTLAIIK PDIVDKEEEI QDIILRSGFT IVQRRKLRLS PEQCSNFYVE
KYGKMFFPNL TAYMSSGPLV AMILARHKAI SYWLELLGPN NSLVAKETHP DSLRAIYGTD
DLRNALHGSN DFAAAEREIR FMFPEVIVEP IPIGQAAKDY LNLHIMPTLL EGLTELCKQK
PADPLIWLAD WLLKNNPNKP KLCHHPIVEE PY
