ID   AROC_TOXGO              Reviewed;         536 AA.
AC   O02607;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Chorismate synthase;
DE            EC=4.2.3.5;
DE   AltName: Full=5-enolpyruvylshikimate-3-phosphate phospholyase;
GN   Name=AROC;
OS   Toxoplasma gondii.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX   NCBI_TaxID=5811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=RH;
RA   Roberts F., Roberts C.W., Johnson J.J., Milhous W., Kyle D., Tzipori S.,
RA   Ferguson D.J.P.;
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate +
CC         phosphate; Xref=Rhea:RHEA:21020, ChEBI:CHEBI:29748,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57701; EC=4.2.3.5;
CC   -!- COFACTOR:
CC       Name=FMNH2; Xref=ChEBI:CHEBI:57618; Evidence={ECO:0000250};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       7/7.
CC   -!- SIMILARITY: Belongs to the chorismate synthase family. {ECO:0000305}.
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DR   EMBL; U93689; AAB52422.1; -; mRNA.
DR   AlphaFoldDB; O02607; -.
DR   SMR; O02607; -.
DR   VEuPathDB; ToxoDB:TGARI_201380; -.
DR   VEuPathDB; ToxoDB:TGCAST_201380; -.
DR   VEuPathDB; ToxoDB:TGCOUG_201380; -.
DR   VEuPathDB; ToxoDB:TGDOM2_201380; -.
DR   VEuPathDB; ToxoDB:TGFOU_201380; -.
DR   VEuPathDB; ToxoDB:TGGT1_201380; -.
DR   VEuPathDB; ToxoDB:TGMAS_201380; -.
DR   VEuPathDB; ToxoDB:TGME49_201380; -.
DR   VEuPathDB; ToxoDB:TGP89_201380; -.
DR   VEuPathDB; ToxoDB:TGPRC2_201380; -.
DR   VEuPathDB; ToxoDB:TGRH88_037370; -.
DR   VEuPathDB; ToxoDB:TGRUB_201380; -.
DR   VEuPathDB; ToxoDB:TGVAND_201380; -.
DR   VEuPathDB; ToxoDB:TGVEG_201380; -.
DR   UniPathway; UPA00053; UER00090.
DR   GO; GO:0004107; F:chorismate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd07304; Chorismate_synthase; 1.
DR   Gene3D; 3.60.150.10; -; 2.
DR   HAMAP; MF_00300; Chorismate_synth; 1.
DR   InterPro; IPR000453; Chorismate_synth.
DR   InterPro; IPR035904; Chorismate_synth_AroC_sf.
DR   InterPro; IPR020541; Chorismate_synthase_CS.
DR   PANTHER; PTHR21085; PTHR21085; 1.
DR   Pfam; PF01264; Chorismate_synt; 2.
DR   SUPFAM; SSF103263; SSF103263; 2.
DR   PROSITE; PS00787; CHORISMATE_SYNTHASE_1; 1.
DR   PROSITE; PS00788; CHORISMATE_SYNTHASE_2; 1.
DR   PROSITE; PS00789; CHORISMATE_SYNTHASE_3; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Lyase.
FT   CHAIN           1..536
FT                   /note="Chorismate synthase"
FT                   /id="PRO_0000140701"
FT   REGION          37..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          344..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        359..377
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  58144 MW;  B25E7BEC1BAEFC19 CRC64;
     MSSYGAALRI HTFGESHGSA VGCIIDGLPP RLPLSVEDVQ PQLNRRRPGQ GPLSTQRREK
     DRVNILSGVE DGYTLGTPLA MLVWNEDRRP QEYHALATVP RPGHGDFTYH AKYHIHAKSG
     GGRSSARETL ARVAAGAVVE KWLGMHYGTS FTAWVCQVGD VSVPRSLRRK WERQPPTRQD
     VDRLGVVRVS PDGTTFLDAN NRLYDERGEE LVEEEDKARR RLLFGVDNPT PGETVIETRC
     PCPSTAVRMA VKINQTRSLG DSIGGCISGA IVRPPLGLGE PCFDKVEAEL AKAMMSLPAT
     KGFEIGQGFA SVTLRGSEHN DRFIPFERAS CSFSESAAST IKHERDGCSA ATLSRERASD
     GRTTSRHEEE VERGRERIQR DTLHVTGVDQ QNGNSEDSVR YTSKSEASIT RLSGNAASGG
     APVCRIPLGE GVRIRCGSNN AGGTLAGITS GENIFFRVAF KPVSSIGLEQ ETADFAGEMN
     QLAVKGRHDP CVLPRAPPLV ESMAALVIGD LCLRQRAREG PHPLLVLPQH SGCPSC