ID   NDL1A_DANRE             Reviewed;         344 AA.
AC   Q7SXI6;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Nuclear distribution protein nudE-like 1-A;
GN   Name=ndel1a;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for organization of the cellular microtubule array
CC       and microtubule anchoring at the centrosome. Positively regulates the
CC       activity of the minus-end directed microtubule motor protein dynein.
CC       May enhance dynein-mediated microtubule sliding by targeting dynein to
CC       the microtubule plus end (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to the
CC       interphase centrosome and the mitotic spindle. {ECO:0000250}.
CC   -!- PTM: Phosphorylated in mitosis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nudE family. {ECO:0000305}.
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DR   EMBL; BC055587; AAH55587.1; -; mRNA.
DR   RefSeq; NP_958501.1; NM_201344.1.
DR   AlphaFoldDB; Q7SXI6; -.
DR   SMR; Q7SXI6; -.
DR   STRING; 7955.ENSDARP00000003032; -.
DR   PaxDb; Q7SXI6; -.
DR   GeneID; 394244; -.
DR   KEGG; dre:394244; -.
DR   CTD; 394244; -.
DR   ZFIN; ZDB-GENE-040115-2; ndel1a.
DR   eggNOG; KOG1853; Eukaryota.
DR   InParanoid; Q7SXI6; -.
DR   OrthoDB; 1082224at2759; -.
DR   PhylomeDB; Q7SXI6; -.
DR   PRO; PR:Q7SXI6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0051642; P:centrosome localization; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR   GO; GO:0051303; P:establishment of chromosome localization; IBA:GO_Central.
DR   GO; GO:0000132; P:establishment of mitotic spindle orientation; IBA:GO_Central.
DR   GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR   GO; GO:0007100; P:mitotic centrosome separation; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR   GO; GO:0060052; P:neurofilament cytoskeleton organization; IEA:InterPro.
DR   GO; GO:0010975; P:regulation of neuron projection development; IBA:GO_Central.
DR   GO; GO:0047496; P:vesicle transport along microtubule; IBA:GO_Central.
DR   InterPro; IPR033493; NDEL1.
DR   InterPro; IPR033494; NUDE.
DR   InterPro; IPR006964; NUDE_dom.
DR   PANTHER; PTHR10921; PTHR10921; 1.
DR   PANTHER; PTHR10921:SF0; PTHR10921:SF0; 1.
DR   Pfam; PF04880; NUDE_C; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein;
KW   Reference proteome; Transport.
FT   CHAIN           1..344
FT                   /note="Nuclear distribution protein nudE-like 1-A"
FT                   /id="PRO_0000240217"
FT   REGION          181..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          26..187
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        190..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..344
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   344 AA;  38629 MW;  18D8BC057599C9C3 CRC64;
     MDADMIPKFT TKEEEIDFWK ALSLKYKKSY KEAQEELLEF QEGSRELETE LETQLGQAEH
     RIRDLQADNQ RLQHELDSLK EKLEYQYAQS YKQISVLEDD LSQTRGIKEQ LHKYVRELEQ
     ANDDLERAKR ATITSLEDFE QRLNQAIERN AFLESELDEK ESLLVSVQRL KDEARDLRQE
     LAVRDTRSEV TRMSAPSSPT PDNDKTDSAV QASLSLPATP LSKNLDNAFT SQTVLANGST
     NAALTPSARI SALNIVGDLL RKVGALESKL AACRNFAKDQ AARKNYVTNV NGNLINGDIS
     NYSHSLHTSY FDKARTVNGL DPGDGTHITA PPRSNSPSGL VLSV