ID   NDL1A_XENLA             Reviewed;         345 AA.
AC   Q6DK98;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Nuclear distribution protein nudE-like 1-A;
GN   Name=ndel1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for organization of the cellular microtubule array
CC       and microtubule anchoring at the centrosome. Positively regulates the
CC       activity of the minus-end directed microtubule motor protein dynein.
CC       May enhance dynein-mediated microtubule sliding by targeting dynein to
CC       the microtubule plus end. Positively regulates lysosome peripheral
CC       distribution and ruffled border formation in osteoclasts. {ECO:0000250,
CC       ECO:0000250|UniProtKB:Q9ERR1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to the
CC       interphase centrosome and the mitotic spindle. {ECO:0000250}.
CC   -!- PTM: Phosphorylated in mitosis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nudE family. {ECO:0000305}.
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DR   EMBL; BC074498; AAH74498.1; -; mRNA.
DR   RefSeq; NP_001086332.1; NM_001092863.1.
DR   RefSeq; XP_018089890.1; XM_018234401.1.
DR   AlphaFoldDB; Q6DK98; -.
DR   SMR; Q6DK98; -.
DR   BioGRID; 102924; 1.
DR   DNASU; 444761; -.
DR   GeneID; 444761; -.
DR   KEGG; xla:444761; -.
DR   CTD; 444761; -.
DR   Xenbase; XB-GENE-989308; ndel1.L.
DR   OMA; EVEALKX; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 444761; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0007100; P:mitotic centrosome separation; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR   GO; GO:0060052; P:neurofilament cytoskeleton organization; IEA:InterPro.
DR   GO; GO:1900029; P:positive regulation of ruffle assembly; ISS:UniProtKB.
DR   InterPro; IPR033493; NDEL1.
DR   InterPro; IPR033494; NUDE.
DR   InterPro; IPR006964; NUDE_dom.
DR   PANTHER; PTHR10921; PTHR10921; 1.
DR   PANTHER; PTHR10921:SF0; PTHR10921:SF0; 1.
DR   Pfam; PF04880; NUDE_C; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein;
KW   Reference proteome; Transport.
FT   CHAIN           1..345
FT                   /note="Nuclear distribution protein nudE-like 1-A"
FT                   /id="PRO_0000240219"
FT   REGION          182..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          326..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          19..190
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        192..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        330..345
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  38622 MW;  603B8D6F541AFFCC CRC64;
     MENEEIPEFL SPKEEIVYWR ELSKRLKQSY QEARDELIEF QEGSRELEAE LETQLVQAEQ
     RNRDLLSDNQ RLKCEVESLK EKLEHQYAQS YKQVSLLEDE LARARSIKDQ LHKYVRELEQ
     ANDDLERAKR ATIVSLEDFE QRLNQAIERN AFLESELDEK ESLLVSVQRL KDEARDLRQE
     LAVRERQTDG TRKSAPSSPT LDCDKTDSAV QASLSLPATP VGKICDNSFT SPKGIPNGFG
     TTPLTPSARI SALNIVGDLL RKVGALESKL AACRNFAKDQ ASRKSYTPVN LNSNSSSSVL
     NSSGVKYSHA GHTSFFDKGA VNGYEPPGVL GSRPPSPPGM LPLSV