ID   NDL1B_DANRE             Reviewed;         344 AA.
AC   Q803Q2;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Nuclear distribution protein nudE-like 1-B;
GN   Name=ndel1b;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for organization of the cellular microtubule array
CC       and microtubule anchoring at the centrosome. Positively regulates the
CC       activity of the minus-end directed microtubule motor protein dynein.
CC       May enhance dynein-mediated microtubule sliding by targeting dynein to
CC       the microtubule plus end (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to the
CC       interphase centrosome and the mitotic spindle. {ECO:0000250}.
CC   -!- PTM: Phosphorylated in mitosis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nudE family. {ECO:0000305}.
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DR   EMBL; BC044386; AAH44386.2; -; mRNA.
DR   RefSeq; NP_958464.1; NM_201307.2.
DR   AlphaFoldDB; Q803Q2; -.
DR   SMR; Q803Q2; -.
DR   STRING; 7955.ENSDARP00000055681; -.
DR   PaxDb; Q803Q2; -.
DR   PRIDE; Q803Q2; -.
DR   Ensembl; ENSDART00000169923; ENSDARP00000140064; ENSDARG00000104225.
DR   Ensembl; ENSDART00000189027; ENSDARP00000148946; ENSDARG00000104225.
DR   Ensembl; ENSDART00000190073; ENSDARP00000152129; ENSDARG00000115289.
DR   GeneID; 333957; -.
DR   KEGG; dre:333957; -.
DR   CTD; 333957; -.
DR   ZFIN; ZDB-GENE-030131-5889; ndel1b.
DR   eggNOG; KOG1853; Eukaryota.
DR   GeneTree; ENSGT00390000000111; -.
DR   HOGENOM; CLU_057872_0_0_1; -.
DR   InParanoid; Q803Q2; -.
DR   OMA; KTYREHA; -.
DR   OrthoDB; 1082224at2759; -.
DR   PhylomeDB; Q803Q2; -.
DR   TreeFam; TF325693; -.
DR   Reactome; R-DRE-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-DRE-2467813; Separation of Sister Chromatids.
DR   Reactome; R-DRE-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-DRE-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-DRE-9648025; EML4 and NUDC in mitotic spindle formation.
DR   PRO; PR:Q803Q2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 3.
DR   Bgee; ENSDARG00000104225; Expressed in cleaving embryo and 27 other tissues.
DR   ExpressionAtlas; Q803Q2; baseline.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0051642; P:centrosome localization; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR   GO; GO:0051303; P:establishment of chromosome localization; IBA:GO_Central.
DR   GO; GO:0000132; P:establishment of mitotic spindle orientation; IBA:GO_Central.
DR   GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR   GO; GO:0007100; P:mitotic centrosome separation; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR   GO; GO:0060052; P:neurofilament cytoskeleton organization; IEA:InterPro.
DR   GO; GO:0010975; P:regulation of neuron projection development; IBA:GO_Central.
DR   GO; GO:0047496; P:vesicle transport along microtubule; IBA:GO_Central.
DR   InterPro; IPR033493; NDEL1.
DR   InterPro; IPR033494; NUDE.
DR   InterPro; IPR006964; NUDE_dom.
DR   PANTHER; PTHR10921; PTHR10921; 1.
DR   PANTHER; PTHR10921:SF0; PTHR10921:SF0; 1.
DR   Pfam; PF04880; NUDE_C; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein;
KW   Reference proteome; Transport.
FT   CHAIN           1..344
FT                   /note="Nuclear distribution protein nudE-like 1-B"
FT                   /id="PRO_0000240218"
FT   COILED          26..189
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   344 AA;  38443 MW;  DEA72B0099C5008E CRC64;
     MDTEMMPKFS SKDEEIDYWK CLSLKYKKSC HDAQEELQEF QEGSRELEAE LEAQLGQAEH
     RIRDLQSENQ RLKSEVDILK EKLEQQYAQS YKQISMLEDD LLQTRGIKEQ LHKYVRELEQ
     ANDDLERAKR ATITSLEDFE QRLNQAIERN AFLESELDEK ESLLVSVQRL KDEARDLRQE
     LAVRERTSDV TRMSAPSSPT LDIDKTDSAV QASLSLPATP VGKTMEHPFI GTKALTNGCG
     NGSPLTPSAR ISALNIVGDL LRKVGALESK LAACRNFAKD QAARKNYTTG NGNLINSNAT
     KFSHSLHTTY FDKTTMNGLD PGALSAAIAS PRAVSPPGLL PLSV