ID   NDL1B_XENLA             Reviewed;         344 AA.
AC   Q66IZ7;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Nuclear distribution protein nudE-like 1-B;
GN   Name=ndel1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for organization of the cellular microtubule array
CC       and microtubule anchoring at the centrosome. Positively regulates the
CC       activity of the minus-end directed microtubule motor protein dynein.
CC       May enhance dynein-mediated microtubule sliding by targeting dynein to
CC       the microtubule plus end. Positively regulates lysosome peripheral
CC       distribution and ruffled border formation in osteoclasts. {ECO:0000250,
CC       ECO:0000250|UniProtKB:Q9ERR1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to the
CC       interphase centrosome and the mitotic spindle. {ECO:0000250}.
CC   -!- PTM: Phosphorylated in mitosis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nudE family. {ECO:0000305}.
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DR   EMBL; BC081127; AAH81127.1; -; mRNA.
DR   RefSeq; NP_001087713.1; NM_001094244.1.
DR   AlphaFoldDB; Q66IZ7; -.
DR   SMR; Q66IZ7; -.
DR   DNASU; 447537; -.
DR   GeneID; 447537; -.
DR   KEGG; xla:447537; -.
DR   CTD; 447537; -.
DR   Xenbase; XB-GENE-6253763; ndel1.S.
DR   OMA; KTYREHA; -.
DR   OrthoDB; 1082224at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 447537; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0007100; P:mitotic centrosome separation; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR   GO; GO:0060052; P:neurofilament cytoskeleton organization; IEA:InterPro.
DR   GO; GO:1900029; P:positive regulation of ruffle assembly; ISS:UniProtKB.
DR   InterPro; IPR033493; NDEL1.
DR   InterPro; IPR033494; NUDE.
DR   InterPro; IPR006964; NUDE_dom.
DR   PANTHER; PTHR10921; PTHR10921; 1.
DR   PANTHER; PTHR10921:SF0; PTHR10921:SF0; 1.
DR   Pfam; PF04880; NUDE_C; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein;
KW   Reference proteome; Transport.
FT   CHAIN           1..344
FT                   /note="Nuclear distribution protein nudE-like 1-B"
FT                   /id="PRO_0000240220"
FT   REGION          186..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          325..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..190
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        192..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..344
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   344 AA;  38470 MW;  91F1EFBDEFDFD7F0 CRC64;
     MENEEIPEFL SPKEEIVYWR ELAKRLKQSY QEARDELIEF QEGSRELEAE LETQLIQAEQ
     RNRDLLGDNQ RLKCEVDSLK EKLEHQYAQS YKQVSLLEDE LVRARSIKDQ LHKYVRELEQ
     ANDDLERAKR ATIVSLEDFE QRLNQAIERN AFLESELDEK ESLLVSVQRL KDEARDLRQE
     LAVRERQTDG IRKSAPSSPT LDCEKTDSSV QASLSLPATP VGKISENSFT SPKGIPNGFG
     TTPLTPSARI SALNIVGDLL RKVGALESKL AACRNFAKDQ ASRKSYTPAN LNSSSSSVLN
     SSGVKYSHAG HTSFFDKGAV NGYDPPGVLG SRPPSPPGLL PLSV