ID   NDL1_ARATH              Reviewed;         346 AA.
AC   Q9FJT7;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Protein NDL1 {ECO:0000305};
DE   AltName: Full=Protein N-MYC DOWNREGULATED-LIKE 1 {ECO:0000303|PubMed:19948787};
GN   Name=NDL1 {ECO:0000303|PubMed:19948787};
GN   OrderedLocusNames=At5g56750 {ECO:0000312|Araport:AT5G56750};
GN   ORFNames=MIK19.22 {ECO:0000312|EMBL:BAB09893.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA   Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT   features of the regions of 1,367,185 bp covered by 19 physically assigned
RT   P1 and TAC clones.";
RL   DNA Res. 5:203-216(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   FUNCTION, INTERACTION WITH GB1; GG1; GG2 AND RGS1, SUBCELLULAR LOCATION,
RP   TISSUE SPECIFICITY, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19948787; DOI=10.1105/tpc.109.065557;
RA   Mudgil Y., Uhrig J.F., Zhou J., Temple B., Jiang K., Jones A.M.;
RT   "Arabidopsis N-MYC DOWNREGULATED-LIKE1, a positive regulator of auxin
RT   transport in a G protein-mediated pathway.";
RL   Plant Cell 21:3591-3609(2009).
RN   [6]
RP   FUNCTION.
RX   PubMed=24223735; DOI=10.1371/journal.pone.0077863;
RA   Mudgil Y., Ghawana S., Jones A.M.;
RT   "N-MYC down-regulated-like proteins regulate meristem initiation by
RT   modulating auxin transport and MAX2 expression.";
RL   PLoS ONE 8:E77863-E77863(2013).
CC   -!- FUNCTION: Interacts with the heterotrimeric G protein beta subunit GB1
CC       and plays an significant role in GB1-dependent regulation of lateral
CC       root formation. Involved in a signaling pathway that modulates root
CC       auxin transport and auxin gradients. Acts partially by positively
CC       regulating the auxin carrier PIN2 and AUX1 (PubMed:19948787). Acts,
CC       together with GB1 as positive regulator of meristem initiation and
CC       branching. GB1 and NDL1 positively regulate basipetal inflorescence
CC       auxin transport and modulate MAX2 expression in shoots, which regulates
CC       organ and lateral meristem formation by the establishment and
CC       maintenance of auxin gradients (PubMed:24223735).
CC       {ECO:0000269|PubMed:19948787, ECO:0000269|PubMed:24223735}.
CC   -!- SUBUNIT: Interacts with GB1. Interacts with the heterodimers formed by
CC       GB1 and GG1, or GB1 and GG2. Interacts with RGS1.
CC       {ECO:0000269|PubMed:19948787}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19948787}.
CC       Note=Localizes in punctate cytoplasmic structures.
CC       {ECO:0000269|PubMed:19948787}.
CC   -!- TISSUE SPECIFICITY: Expressed in root vasculature, cotyledons, leaves,
CC       petals, mature stamens and pollen grains.
CC       {ECO:0000269|PubMed:19948787}.
CC   -!- INDUCTION: Induced by sucrose and glucose. Down-regulated by auxin.
CC       {ECO:0000269|PubMed:19948787}.
CC   -!- DISRUPTION PHENOTYPE: Slight reduction in length of primary root.
CC       {ECO:0000269|PubMed:19948787}.
CC   -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB013392; BAB09893.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED96803.1; -; Genomic_DNA.
DR   EMBL; AY050428; AAK91444.1; -; mRNA.
DR   EMBL; AY090332; AAL90993.1; -; mRNA.
DR   EMBL; AY087544; AAM65086.1; -; mRNA.
DR   RefSeq; NP_200486.1; NM_125058.3.
DR   AlphaFoldDB; Q9FJT7; -.
DR   SMR; Q9FJT7; -.
DR   STRING; 3702.AT5G56750.1; -.
DR   ESTHER; arath-At5g56750; Ndr_family.
DR   PaxDb; Q9FJT7; -.
DR   PRIDE; Q9FJT7; -.
DR   EnsemblPlants; AT5G56750.1; AT5G56750.1; AT5G56750.
DR   GeneID; 835777; -.
DR   Gramene; AT5G56750.1; AT5G56750.1; AT5G56750.
DR   KEGG; ath:AT5G56750; -.
DR   Araport; AT5G56750; -.
DR   TAIR; locus:2165101; AT5G56750.
DR   eggNOG; KOG2931; Eukaryota.
DR   HOGENOM; CLU_035361_2_0_1; -.
DR   InParanoid; Q9FJT7; -.
DR   OrthoDB; 854690at2759; -.
DR   PhylomeDB; Q9FJT7; -.
DR   PRO; PR:Q9FJT7; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FJT7; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0060918; P:auxin transport; IMP:TAIR.
DR   GO; GO:2000012; P:regulation of auxin polar transport; IMP:UniProtKB.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   GO; GO:0009733; P:response to auxin; IDA:TAIR.
DR   GO; GO:0009753; P:response to jasmonic acid; IDA:TAIR.
DR   GO; GO:0009751; P:response to salicylic acid; IDA:TAIR.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR004142; NDRG.
DR   PANTHER; PTHR11034; PTHR11034; 1.
DR   Pfam; PF03096; Ndr; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Growth regulation; Reference proteome.
FT   CHAIN           1..346
FT                   /note="Protein NDL1"
FT                   /id="PRO_0000442104"
SQ   SEQUENCE   346 AA;  38299 MW;  3B76D61EE0931707 CRC64;
     MTDSYGAVSV DVGTIYLGGK EHRVKTASGV VSVIVYGDRE KPALITYPDL ALNHMSCFQG
     LFFCPEAASL LLHNFCIYHI SPPGHELGAA PICPNDSVPS AENLADQILE VLNFFGLGVV
     MCMGVTAGAY ILTLFAMKHR ERVLGLILVS PLCKAPSWSE WFYNKVITNL LYYYGMCGVV
     KEFLLQRYFS KEVRGNVEIP ESDIAQACRR LLDERQGINV LRFLDAIDRR PDISSGLKKL
     KCRTLIFIGD QSPFYSEAVH MAATLDRGYC ALVEVQACGS MVTEEQPHAM LIPMEYFLMG
     YGLYRPSLFS ESPRSPLSPS CISPELLSPE SMGLKLKPIK TRISAA