NDL2_ARATH
ID NDL2_ARATH Reviewed; 344 AA.
AC Q9ASU8; C0Z3F8; Q9LYF2;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Protein NDL2 {ECO:0000305};
DE AltName: Full=Protein N-MYC DOWNREGULATED-LIKE 2 {ECO:0000303|PubMed:19948787};
GN Name=NDL2 {ECO:0000303|PubMed:19948787};
GN OrderedLocusNames=At5g11790 {ECO:0000312|Araport:AT5G11790};
GN ORFNames=T22P22_180 {ECO:0000312|EMBL:CAB87697.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [5]
RP FUNCTION, AND INTERACTION WITH GB1; GG1; GG2 AND RGS1.
RX PubMed=19948787; DOI=10.1105/tpc.109.065557;
RA Mudgil Y., Uhrig J.F., Zhou J., Temple B., Jiang K., Jones A.M.;
RT "Arabidopsis N-MYC DOWNREGULATED-LIKE1, a positive regulator of auxin
RT transport in a G protein-mediated pathway.";
RL Plant Cell 21:3591-3609(2009).
RN [6]
RP FUNCTION.
RX PubMed=24223735; DOI=10.1371/journal.pone.0077863;
RA Mudgil Y., Ghawana S., Jones A.M.;
RT "N-MYC down-regulated-like proteins regulate meristem initiation by
RT modulating auxin transport and MAX2 expression.";
RL PLoS ONE 8:E77863-E77863(2013).
CC -!- FUNCTION: Involved in a signaling pathway that modulates root auxin
CC transport and auxin gradients. Acts partially by positively regulating
CC the auxin carrier PIN2 and AUX1 (PubMed:19948787). Acts, together with
CC GB1 as positive regulator of meristem initiation and branching. GB1 and
CC NDL2 positively regulate basipetal inflorescence auxin transport and
CC modulate MAX2 expression in shoots, which regulates organ and lateral
CC meristem formation by the establishment and maintenance of auxin
CC gradients (PubMed:24223735). {ECO:0000269|PubMed:19948787,
CC ECO:0000269|PubMed:24223735}.
CC -!- SUBUNIT: Interacts with the heterodimers formed by GB1 and GG1, or GB1
CC and GG2. Interacts with RGS1. {ECO:0000269|PubMed:19948787}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9FJT7}.
CC -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAH57237.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAB87697.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL163814; CAB87697.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED91721.1; -; Genomic_DNA.
DR EMBL; AF361823; AAK32835.1; -; mRNA.
DR EMBL; AY059161; AAL15386.1; -; mRNA.
DR EMBL; AK319122; BAH57237.1; ALT_FRAME; mRNA.
DR PIR; T48538; T48538.
DR RefSeq; NP_568251.1; NM_121217.3.
DR AlphaFoldDB; Q9ASU8; -.
DR SMR; Q9ASU8; -.
DR STRING; 3702.AT5G11790.1; -.
DR ESTHER; arath-At5g11790; Ndr_family.
DR PaxDb; Q9ASU8; -.
DR PRIDE; Q9ASU8; -.
DR EnsemblPlants; AT5G11790.1; AT5G11790.1; AT5G11790.
DR GeneID; 831051; -.
DR Gramene; AT5G11790.1; AT5G11790.1; AT5G11790.
DR KEGG; ath:AT5G11790; -.
DR Araport; AT5G11790; -.
DR TAIR; locus:2181905; AT5G11790.
DR eggNOG; KOG2931; Eukaryota.
DR HOGENOM; CLU_035361_2_0_1; -.
DR InParanoid; Q9ASU8; -.
DR OMA; KTCFQPL; -.
DR OrthoDB; 854690at2759; -.
DR PhylomeDB; Q9ASU8; -.
DR PRO; PR:Q9ASU8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9ASU8; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:2000012; P:regulation of auxin polar transport; IMP:UniProtKB.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR GO; GO:0009737; P:response to abscisic acid; IDA:TAIR.
DR GO; GO:0009409; P:response to cold; IDA:TAIR.
DR GO; GO:0009753; P:response to jasmonic acid; IDA:TAIR.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004142; NDRG.
DR PANTHER; PTHR11034; PTHR11034; 1.
DR Pfam; PF03096; Ndr; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Growth regulation; Reference proteome.
FT CHAIN 1..344
FT /note="Protein NDL2"
FT /id="PRO_0000442105"
SQ SEQUENCE 344 AA; 38179 MW; 55953F330AD76F4E CRC64;
MADSSDSVSI DMEALSLGGQ EHLVETTYGP VCVAVCGDPD KPALITYPDI ALNYMFCFQG
LLFCPEASSL LLHNFCIYHI SPLGHELGAP MISVDAPLLS ADDLADQIVE VLNYFGLGAV
MCMGVTAGAY ILTLFAMKYR QRVLGLILVS PLCQAPSWSE WLCNKVMSNL LYYYGTCGVV
KEMLLKRYFS KEVRGNGHVP ESDIVQECRR LLSERQSTNV WRFLEAINGR VDLSEGLRKL
QCRTLIFIGE NSAYHSEAVH MTTKLDRRYG ALVEVQGSGS LVSEEQPQAM IIPMEYFLMG
YGLYRPTQSV SPRSPLSPTR ISPELLSPEN MGLKLKPIKT RLAL
