ID   NDL3_ARATH              Reviewed;         347 AA.
AC   Q9ZUN1;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Protein NDL3 {ECO:0000305};
DE   AltName: Full=Protein N-MYC DOWNREGULATED-LIKE 3 {ECO:0000303|PubMed:19948787};
GN   Name=NDL3 {ECO:0000303|PubMed:19948787};
GN   OrderedLocusNames=At2g19620 {ECO:0000312|Araport:AT2G19620};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH GB1; GG1; GG2 AND RGS1.
RX   PubMed=19948787; DOI=10.1105/tpc.109.065557;
RA   Mudgil Y., Uhrig J.F., Zhou J., Temple B., Jiang K., Jones A.M.;
RT   "Arabidopsis N-MYC DOWNREGULATED-LIKE1, a positive regulator of auxin
RT   transport in a G protein-mediated pathway.";
RL   Plant Cell 21:3591-3609(2009).
RN   [4]
RP   FUNCTION.
RX   PubMed=24223735; DOI=10.1371/journal.pone.0077863;
RA   Mudgil Y., Ghawana S., Jones A.M.;
RT   "N-MYC down-regulated-like proteins regulate meristem initiation by
RT   modulating auxin transport and MAX2 expression.";
RL   PLoS ONE 8:E77863-E77863(2013).
CC   -!- FUNCTION: Involved in a signaling pathway that modulates root auxin
CC       transport and auxin gradients. Acts partially by positively regulating
CC       the auxin carrier PIN2 and AUX1 (PubMed:19948787). Acts, together with
CC       GB1 as positive regulator of meristem initiation and branching. GB1 and
CC       NDL3 positively regulate basipetal inflorescence auxin transport and
CC       modulate MAX2 expression in shoots, which regulates organ and lateral
CC       meristem formation by the establishment and maintenance of auxin
CC       gradients (PubMed:24223735). {ECO:0000269|PubMed:19948787,
CC       ECO:0000269|PubMed:24223735}.
CC   -!- SUBUNIT: Interacts with the heterodimers formed by GB1 and GG1, or GB1
CC       and GG2. Interacts with RGS1. {ECO:0000269|PubMed:19948787}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9FJT7}.
CC   -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000305}.
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DR   EMBL; AC005917; AAD10160.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06902.1; -; Genomic_DNA.
DR   PIR; A84579; A84579.
DR   RefSeq; NP_179552.1; NM_127520.4.
DR   AlphaFoldDB; Q9ZUN1; -.
DR   SMR; Q9ZUN1; -.
DR   STRING; 3702.AT2G19620.1; -.
DR   ESTHER; arath-At2g19620; Ndr_family.
DR   PaxDb; Q9ZUN1; -.
DR   PRIDE; Q9ZUN1; -.
DR   ProteomicsDB; 249376; -.
DR   EnsemblPlants; AT2G19620.1; AT2G19620.1; AT2G19620.
DR   GeneID; 816481; -.
DR   Gramene; AT2G19620.1; AT2G19620.1; AT2G19620.
DR   KEGG; ath:AT2G19620; -.
DR   Araport; AT2G19620; -.
DR   TAIR; locus:2050404; AT2G19620.
DR   eggNOG; KOG2931; Eukaryota.
DR   InParanoid; Q9ZUN1; -.
DR   OrthoDB; 854690at2759; -.
DR   PhylomeDB; Q9ZUN1; -.
DR   PRO; PR:Q9ZUN1; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9ZUN1; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:2000012; P:regulation of auxin polar transport; IMP:UniProtKB.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   GO; GO:0009737; P:response to abscisic acid; IDA:TAIR.
DR   GO; GO:0009409; P:response to cold; IDA:TAIR.
DR   GO; GO:0009753; P:response to jasmonic acid; IDA:TAIR.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR004142; NDRG.
DR   PANTHER; PTHR11034; PTHR11034; 1.
DR   Pfam; PF03096; Ndr; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Growth regulation; Reference proteome.
FT   CHAIN           1..347
FT                   /note="Protein NDL3"
FT                   /id="PRO_0000442106"
SQ   SEQUENCE   347 AA;  38702 MW;  07554255A55CABF4 CRC64;
     MVGLNNAVSL DIEEICNGGK EHHVKTCHGS VSVVVYGDQE KPALITYPDV ALNYMSCFQG
     LFLCPEAVSL LLHNFCIYHI SPPGHEFGAA PVCSNDPSPS VEDLADQILE VLNFFSLEAV
     MCMGITAGAY ILSLFAIKHK ERVLGLILIS PLCKAPSWSE WFYYKVVSNL LYYYGMSGLL
     KDIFLQRYFS KEARGSSEVP ERDVVHECRR LLGERHGSSL MRFLEAVNRR HDLTDGLKSL
     KCRTLIFVGD QSPFHSETLH MVTALDRKYS ALVEVQACGS MVTEEQPHAM LIPMEFFFMG
     FGLYRPGRVS DSPRSPLSPS CISPELLSPE SLGLKLKPIK TRVPTKC