ID   NDNF_DANRE              Reviewed;         574 AA.
AC   F1QPX0;
DT   10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2016, sequence version 2.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Protein NDNF {ECO:0000305};
DE   Flags: Precursor;
GN   Name=ndnf {ECO:0000312|ZFIN:ZDB-GENE-030131-207};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=31883645; DOI=10.1016/j.ajhg.2019.12.003;
RA   Messina A., Pulli K., Santini S., Acierno J., Kaensaekoski J.,
RA   Cassatella D., Xu C., Casoni F., Malone S.A., Ternier G., Conte D.,
RA   Sidis Y., Tommiska J., Vaaralahti K., Dwyer A., Gothilf Y., Merlo G.R.,
RA   Santoni F., Niederlaender N.J., Giacobini P., Raivio T., Pitteloud N.;
RT   "Neuron-derived neurotrophic factor is mutated in congenital
RT   hypogonadotropic hypogonadism.";
RL   Am. J. Hum. Genet. 106:58-70(2020).
CC   -!- FUNCTION: Secretory protein that plays a role in various cellular
CC       processes. Acts as a chemorepellent acting on gonadotropin-releasing
CC       hormone (GnRH) expressing neurons regulating their migration to the
CC       hypothalamus (PubMed:31883645). Also promotes neuron migration, growth
CC       and survival as well as neurite outgrowth and is involved in the
CC       development of the olfactory system. May also act through the
CC       regulation of growth factors activity and downstream signaling (By
CC       similarity). Also regulates extracellular matrix assembly and cell
CC       adhesiveness (By similarity). Promotes endothelial cell survival,
CC       vessel formation and plays an important role in the process of
CC       revascularization through NOS3-dependent mechanisms (By similarity).
CC       {ECO:0000250|UniProtKB:Q8C119, ECO:0000250|UniProtKB:Q8TB73,
CC       ECO:0000269|PubMed:31883645}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8C119}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein alters the
CC       migration of gonadotropin-releasing hormone (GnRH) expressing neurons.
CC       {ECO:0000269|PubMed:31883645}.
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DR   EMBL; CABZ01060120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01060121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01060125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; LO017828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_689934.5; XM_684842.8.
DR   AlphaFoldDB; F1QPX0; -.
DR   PaxDb; F1QPX0; -.
DR   Ensembl; ENSDART00000091532; ENSDARP00000085965; ENSDARG00000062936.
DR   GeneID; 561437; -.
DR   KEGG; dre:561437; -.
DR   CTD; 79625; -.
DR   ZFIN; ZDB-GENE-030131-207; ndnf.
DR   eggNOG; KOG4806; Eukaryota.
DR   GeneTree; ENSGT00390000007586; -.
DR   HOGENOM; CLU_041753_0_0_1; -.
DR   InParanoid; F1QPX0; -.
DR   OMA; YCVVINR; -.
DR   OrthoDB; 294977at2759; -.
DR   TreeFam; TF313245; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000062936; Expressed in tail bud paraxial mesoderm and 29 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR   GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; ISS:UniProtKB.
DR   GO; GO:0048702; P:embryonic neurocranium morphogenesis; IMP:ZFIN.
DR   GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR   GO; GO:0021828; P:gonadotrophin-releasing hormone neuronal migration to the hypothalamus; IMP:UniProtKB.
DR   GO; GO:0019800; P:peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; IBA:GO_Central.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR019326; NDNF.
DR   InterPro; IPR045805; NDNF_C.
DR   PANTHER; PTHR14619; PTHR14619; 1.
DR   Pfam; PF10179; NDNF; 1.
DR   Pfam; PF19433; NDNF_C; 1.
DR   SMART; SM00060; FN3; 2.
DR   SUPFAM; SSF49265; SSF49265; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Neurogenesis; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..574
FT                   /note="Protein NDNF"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5006466061"
FT   DOMAIN          174..329
FT                   /note="Fibronectin type-III 1"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          451..560
FT                   /note="Fibronectin type-III 2"
FT                   /evidence="ECO:0000255"
FT   REGION          97..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        327
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   574 AA;  64817 MW;  C6F2293A1A951751 CRC64;
     MTWRCGCYGL VLLVLGVMGQ KLPTRDEGLF QMQIRDKAQF HDSSVMPDGA EISGYLFRDT
     PKRYYFVVEE DNTPLLVTVT PCDAPLEWRL TLQELPEDRS GEGSGEPEPL EQQKQQVTAN
     EGTELFTYKG NDVESFISSS SPSGLYQLEI ISTEKDSNFK IYSTTTPESD QPYPELPYDP
     RVDVTALGRT TVTLAWKPTP TGSVMGQPIQ YCVVINKEHN FKSLCAAEAK MSLDDAFMIA
     PKPGRDFSPF DFAYFGFVPS ENDFHKDRFL TTNRALSNKM SRAYIPKPKV ADIQKICIGN
     KNIFTITDLK PDTQYYFDVF AVNTGTNMST AYVGTFARTK EEAKQKTVEL KDGKVTDVFV
     KRKGSKFLRF APVSSHQRVT LFVHACLDAV QVQVRRDGKL VLSQNVEGVR QFQLRGKPKA
     KYLIRLRGSR KGASTLKVLA STRAGGKQPF PALPEDTRIK AFDKLRTCSS VTVAWLGTQE
     RNKYCVYRRE VSESYGEEHR RREQNQCSGP ESRRKSEKVL CKYFYSANLQ KAVTTETITG
     LEAGKSYLLD VYVVGHSGHS VKYQSKLVKT RKYC