ID   NDNF_XENLA              Reviewed;         569 AA.
AC   Q6GNK9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Protein NDNF;
DE   Flags: Precursor;
GN   Name=ndnf;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Secretory protein that plays a role in various cellular
CC       processes. Acts as a chemorepellent acting on gonadotropin-releasing
CC       hormone (GnRH) expressing neurons regulating their migration to the
CC       hypothalamus. Also promotes neuron migration, growth and survival as
CC       well as neurite outgrowth and is involved in the development of the
CC       olfactory system. May also act through the regulation of growth factors
CC       activity and downstream signaling (By similarity). Also regulates
CC       extracellular matrix assembly and cell adhesiveness (By similarity).
CC       Promotes endothelial cell survival, vessel formation and plays an
CC       important role in the process of revascularization through NOS3-
CC       dependent mechanisms (By similarity). {ECO:0000250|UniProtKB:Q8C119,
CC       ECO:0000250|UniProtKB:Q8TB73}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8C119}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC073498; AAH73498.1; -; mRNA.
DR   RefSeq; NP_001085901.1; NM_001092432.1.
DR   AlphaFoldDB; Q6GNK9; -.
DR   DNASU; 444328; -.
DR   GeneID; 444328; -.
DR   KEGG; xla:444328; -.
DR   CTD; 444328; -.
DR   Xenbase; XB-GENE-1016854; ndnf.L.
DR   OrthoDB; 294977at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 444328; Expressed in camera-type eye and 14 other tissues.
DR   GO; GO:0031012; C:extracellular matrix; ISS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005539; F:glycosaminoglycan binding; ISS:UniProtKB.
DR   GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
DR   GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; ISS:UniProtKB.
DR   GO; GO:0030198; P:extracellular matrix organization; ISS:UniProtKB.
DR   GO; GO:0021828; P:gonadotrophin-releasing hormone neuronal migration to the hypothalamus; ISS:UniProtKB.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
DR   GO; GO:0001764; P:neuron migration; ISS:UniProtKB.
DR   GO; GO:0019800; P:peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; ISS:UniProtKB.
DR   GO; GO:0010811; P:positive regulation of cell-substrate adhesion; ISS:UniProtKB.
DR   GO; GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR019326; NDNF.
DR   InterPro; IPR045805; NDNF_C.
DR   PANTHER; PTHR14619; PTHR14619; 1.
DR   Pfam; PF10179; NDNF; 1.
DR   Pfam; PF19433; NDNF_C; 1.
DR   SMART; SM00060; FN3; 2.
DR   SUPFAM; SSF49265; SSF49265; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Neurogenesis; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..569
FT                   /note="Protein NDNF"
FT                   /id="PRO_0000301967"
FT   DOMAIN          261..332
FT                   /note="Fibronectin type-III 1"
FT   DOMAIN          446..565
FT                   /note="Fibronectin type-III 2"
FT   CARBOHYD        323
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   569 AA;  64787 MW;  BC59D3EEC4306DA8 CRC64;
     MKLCRWYIAL FLLPVCLQSQ KLPTRDEELF QMQIRDKALF HDSSVIPDGA EISGYLFRDN
     PKRYFFVVEE DNTPLSVIVT PCDAPLEWKL TLQELPEEAS GEGSGEPEPL EEQKQQIVNE
     EGTELFSYKG NDVEYFVSSS SPSGLYQLEL ISTEKDTHFK VYATTTPESD QPYPELPYDP
     RVDVTSLGRT TITLAWKPTP TSSVMKQPIQ YCVVINKEHN FKSICAVEAK MIADDAFMMA
     PKPGIDFNPF DFAHFGFQSD NSAGKDRNFM PKVSSSKMLR QITKPKVDIQ KFCIGNKNIF
     TVSDLKPDTQ YYFDVFAVNA VTNMSTAYVG TFARTKEEAK QKTVELKDGK VTDVFIKRKG
     TKFLRFSPVS SHQKVTFSVH SCLDAIQIQV RRDGKLLLSQ SVEGVRQFQL RGKPKAKYLI
     RLKGSKKGAS MLKILATSKF NKQPFPSLPE DTRIKAFDKL RTCSSATVAW LGTQERNKFC
     IYKKEVDDDY TEEHKKRDQN QCLGPDTRKK SEKVLCKYFH SQNIHKAVTT ETIKGLQPGK
     SYMLDVYVMG HAGHSVKYQS KIVKTRKFC