ID   NDR1A_XENLA             Reviewed;         396 AA.
AC   Q641F2;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Protein NDRG1-A;
DE            Short=xNDRG1-A;
GN   Name=ndrg1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH82385.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000312|EMBL:AAH82385.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 49-396, FUNCTION, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Kidney {ECO:0000269|PubMed:12943662};
RX   PubMed=12943662; DOI=10.1016/s0006-291x(03)01522-5;
RA   Kyuno J., Fukui A., Michiue T., Asashima M.;
RT   "Identification and characterization of Xenopus NDRG1.";
RL   Biochem. Biophys. Res. Commun. 309:52-57(2003).
CC   -!- FUNCTION: May be involved in pronephros development, after
CC       specification of the pronephros. {ECO:0000269|PubMed:12943662}.
CC   -!- DEVELOPMENTAL STAGE: Zygotically expressed first at a low level at
CC       stage 15. Expression is markedly increased up to stage 20 after which
CC       time the level of expression remains stable. Expressed in the
CC       presumptive pronephric anlagen at stage 26. Localized to pronephros,
CC       eye, branchial arches and tail-bud in the early tadpole stage (stage
CC       32). {ECO:0000269|PubMed:12943662}.
CC   -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000255}.
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DR   EMBL; BC082385; AAH82385.1; -; mRNA.
DR   RefSeq; NP_001087859.1; NM_001094390.1.
DR   AlphaFoldDB; Q641F2; -.
DR   SMR; Q641F2; -.
DR   ESTHER; xenla-ndr1a; Ndr_family.
DR   DNASU; 447720; -.
DR   GeneID; 447720; -.
DR   KEGG; xla:447720; -.
DR   CTD; 447720; -.
DR   Xenbase; XB-GENE-6253402; ndrg1.L.
DR   OrthoDB; 854690at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 447720; Expressed in intestine and 13 other tissues.
DR   GO; GO:0045576; P:mast cell activation; IEA:InterPro.
DR   GO; GO:0032287; P:peripheral nervous system myelin maintenance; IEA:InterPro.
DR   GO; GO:0048793; P:pronephros development; IEP:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR004142; NDRG.
DR   InterPro; IPR030693; NDRG1.
DR   PANTHER; PTHR11034; PTHR11034; 1.
DR   PANTHER; PTHR11034:SF18; PTHR11034:SF18; 1.
DR   Pfam; PF03096; Ndr; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Reference proteome; Repeat.
FT   CHAIN           1..396
FT                   /note="Protein NDRG1-A"
FT                   /id="PRO_0000232425"
FT   REPEAT          340..349
FT                   /note="1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          350..359
FT                   /note="2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          360..369
FT                   /note="3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          370..379
FT                   /note="4"
FT                   /evidence="ECO:0000255"
FT   REGION          326..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..379
FT                   /note="4 X 10 AA tandem repeats of G-[NS]-R-S-R-[AS]-H-T-
FT                   [DGN]-[DET]"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        326..344
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        345..373
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        374..396
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        297
FT                   /note="I -> V (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        335
FT                   /note="S -> T (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   396 AA;  43478 MW;  105405D9371A8526 CRC64;
     MSAEMTDLNF AEGRPLMTDK EDGITVLLQE YVTQEHDIET AHGIVHVTMC GTPKLNRPVI
     LTYHDIGLNH KTCFNSLFNF EDMHEISQHF SVCHVDAPGQ QEGAASFPAG YMYPSMDQLA
     EMLPGVVQQL GLRTVMGLGI GAGAYILTRF ALNHPSMVEG LVLININPCA EGWMDWAATK
     ISGWTNALPD MVISHLFSKD EVHSNPELVE TYRQHILHDI NQNNVQHFVK SYNSRRDLEI
     ERPIPGTNAV TLKCPALLVV GDSSPAVDAV VECNSKLDPT KTTLLKMSDC GGFPQVIQPA
     KLAEAFKYFV QGMGYMPAAS MTRLMRSRTG SAASSSSQDG NRSRSHTNEG SRSRSHTGDG
     NRSRAHTGDG NRSRSHTDTN NINSDQNSPK SMEVSC