ID   NDR4A_XENLA             Reviewed;         390 AA.
AC   Q640Z1; Q5XGS5;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Protein NDRG4-A;
GN   Name=ndrg4-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAH84357.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Eye {ECO:0000312|EMBL:AAH84357.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Contributes to the maintenance of intracerebral BDNF levels
CC       within the normal range. May enhance growth factor-induced ERK1 and
CC       ERK2 phosphorylation. May attenuate growth factor-promoted ELK1
CC       phosphorylation in a microtubule-dependent manner (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q640Z1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q640Z1-2; Sequence=VSP_051978;
CC   -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH84357.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC082448; AAH82448.1; -; mRNA.
DR   EMBL; BC084357; AAH84357.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001087900.1; NM_001094431.1. [Q640Z1-1]
DR   RefSeq; XP_018115154.1; XM_018259665.1. [Q640Z1-2]
DR   AlphaFoldDB; Q640Z1; -.
DR   SMR; Q640Z1; -.
DR   ESTHER; xenla-ndr4a; Ndr_family.
DR   MEROPS; S33.986; -.
DR   DNASU; 447761; -.
DR   GeneID; 447761; -.
DR   KEGG; xla:447761; -.
DR   CTD; 447761; -.
DR   Xenbase; XB-GENE-941133; ndrg4.S.
DR   OMA; HIAQDIC; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 447761; Expressed in brain and 13 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR004142; NDRG.
DR   InterPro; IPR030695; NDRG4.
DR   PANTHER; PTHR11034; PTHR11034; 1.
DR   PANTHER; PTHR11034:SF21; PTHR11034:SF21; 1.
DR   Pfam; PF03096; Ndr; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Reference proteome.
FT   CHAIN           1..390
FT                   /note="Protein NDRG4-A"
FT                   /id="PRO_0000232432"
FT   REGION          356..390
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..23
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_051978"
SQ   SEQUENCE   390 AA;  42993 MW;  3E4DAC753944D228 CRC64;
     MKLLGHKIEL WAGLLLPDVS ISGMSELRFP EEKPLLRGQD TEMESADTFL SAADTDWKEH
     DIETPYGMLH VVIRGTPKGN RPAILTYHDV GLNHKLCFNT FFNYEDMQEI TKHFVVCHVD
     APGQQVGASQ FPQGYQYPTM DQLAAMLPSV MQHFGFQSII AIGVGAGAYV LAKFALIFPE
     LVEGMVLINI DPNGKGWIDW AASKISGLAS SLPETVLSHL FSQEELMNNT ELVQNYRQQI
     SNCVNQSNLQ LFWNMYNSRR DLEMSRPGTA PNAKTLRAPV MLVVGDNAPA EECVVECNSK
     LDPTNTTFLK MADSGGLPQV TQPGKLTEAF KYFLQGMGYM PSASMTRLAR SRTASLTSAS
     SVDGSRPRPC TQSESSDGIG QINHTMEVSC