ID   NDR4B_XENLA             Reviewed;         367 AA.
AC   Q6DJD3;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Protein NDRG4-B;
GN   Name=ndrg4-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH75249.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye {ECO:0000312|EMBL:AAH75249.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Contributes to the maintenance of intracerebral BDNF levels
CC       within the normal range. May enhance growth factor-induced ERK1 and
CC       ERK2 phosphorylation. May attenuate growth factor-promoted ELK1
CC       phosphorylation in a microtubule-dependent manner (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000255}.
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DR   EMBL; BC075249; AAH75249.1; -; mRNA.
DR   RefSeq; NP_001086410.1; NM_001092941.1.
DR   AlphaFoldDB; Q6DJD3; -.
DR   SMR; Q6DJD3; -.
DR   ESTHER; xenla-ndr4b; Ndr_family.
DR   DNASU; 444839; -.
DR   GeneID; 444839; -.
DR   KEGG; xla:444839; -.
DR   CTD; 444839; -.
DR   Xenbase; XB-GENE-6254158; ndrg4.L.
DR   OMA; CMADSGG; -.
DR   OrthoDB; 854690at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 444839; Expressed in brain and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR004142; NDRG.
DR   InterPro; IPR030695; NDRG4.
DR   PANTHER; PTHR11034; PTHR11034; 1.
DR   PANTHER; PTHR11034:SF21; PTHR11034:SF21; 1.
DR   Pfam; PF03096; Ndr; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..367
FT                   /note="Protein NDRG4-B"
FT                   /id="PRO_0000232433"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   367 AA;  40557 MW;  2BDBDF99EECCBAA9 CRC64;
     MSELRFPEEK PLLRGQDTEM ESADTFMSAA DTDWKEHDIE TPYGMLHVVI RGTPKGNRPA
     ILTYHDVGLN HKLCFNTFFN YEDMQEITKH FVVCHVDAPG QQVGASQFPQ GYQYPTMEQL
     AAMLPSVMQH FGFQSIIGIG VGAGAYVFAK FALIFPELVE GMVLINIDPN GKGWIDWAAS
     KLSGLTSSLP ETVLSHLFSQ EELMNNTELV QNYRQQISSC VNQSNLQLFW NMYNSRRDLE
     MSRPGTVPNA KTLRAPVMLV VGDNAPAEDS VVECNSKLDP TNTTFLKMAD SGGLPQVTQP
     GKLTEAFKYF LQGMGYMPSA SMTRLARSRT ASLTSASSVD GARPRPCTQS ESSDGIGQIN
     HTMEVSC