ID   NDRG1_XENTR             Reviewed;         395 AA.
AC   Q66IG4;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Protein NDRG1;
GN   Name=ndrg1 {ECO:0000250|UniProtKB:Q641F2};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH81359.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH81359.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in pronephros development, after
CC       specification of the pronephros. {ECO:0000250|UniProtKB:Q641F2}.
CC   -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000255}.
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DR   EMBL; BC081359; AAH81359.1; -; mRNA.
DR   RefSeq; NP_001008146.1; NM_001008145.1.
DR   AlphaFoldDB; Q66IG4; -.
DR   SMR; Q66IG4; -.
DR   STRING; 8364.ENSXETP00000042148; -.
DR   ESTHER; xentr-ndrg1; Ndr_family.
DR   MEROPS; S33.988; -.
DR   PaxDb; Q66IG4; -.
DR   GeneID; 493508; -.
DR   KEGG; xtr:493508; -.
DR   CTD; 10397; -.
DR   Xenbase; XB-GENE-993273; ndrg1.
DR   eggNOG; KOG2931; Eukaryota.
DR   InParanoid; Q66IG4; -.
DR   OrthoDB; 854690at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0045576; P:mast cell activation; IEA:InterPro.
DR   GO; GO:0032287; P:peripheral nervous system myelin maintenance; IEA:InterPro.
DR   GO; GO:0048793; P:pronephros development; ISS:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR004142; NDRG.
DR   InterPro; IPR030693; NDRG1.
DR   PANTHER; PTHR11034; PTHR11034; 1.
DR   PANTHER; PTHR11034:SF18; PTHR11034:SF18; 1.
DR   Pfam; PF03096; Ndr; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Reference proteome; Repeat.
FT   CHAIN           1..395
FT                   /note="Protein NDRG1"
FT                   /id="PRO_0000232427"
FT   REPEAT          339..348
FT                   /note="1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          349..358
FT                   /note="2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          359..368
FT                   /note="3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          369..378
FT                   /note="4"
FT                   /evidence="ECO:0000255"
FT   REGION          325..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          339..378
FT                   /note="4 X 10 AA tandem repeats of G-[NS]-R-S-R-[AS]-H-T-
FT                   [DGN]-[DES]"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        325..343
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..372
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   395 AA;  43374 MW;  6F6C9AB3E84F5DF0 CRC64;
     MSAEMTDLNF AEGRPLLVDK DGITVLLQEY VTQEHDIETA HGIVHVTMCG TPKLNRPVIL
     TYHDIGLNHK TCFNSLFNFE DMHEITQHFS VCHVDAPGQQ EGAASFPAGY MYPSMDQLAE
     MLPGVIQQLG LKSVLGLGIG AGAYILTRFA LNHPSMVEGL VLININPCAE GWMDWAATKI
     SGWTHALPDM VISHLFSKDE VHSNHELVET YRQHIVQDIN QNNLQLFVKS YNSRRDLEIE
     RPFPGSNTVT LKCPALLVVG DSSPAVDAVV DCNSKLDPTK TTLLKMSDCG GFPQVVQPAK
     LAEAFKYFVQ GMGYMPAASM TRLMRSRTGS AASSSSQDGN RSRSHTNEGS RSRSHTGDGN
     RSRAHTGDGN RSRSHTDSNN TNSEHNTPKS MEISC