ID   NDRG2_DANRE             Reviewed;         368 AA.
AC   Q5PR98;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Protein NDRG2;
GN   Name=ndrg2; ORFNames=zgc:101847;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larva;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Contributes to the regulation of the Wnt signaling pathway.
CC       Down-regulates CTNNB1-mediated transcriptional activation of target
CC       genes. May be involved in neuron differentiation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000305}.
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DR   EMBL; BC086746; AAH86746.1; -; mRNA.
DR   RefSeq; NP_001008593.1; NM_001008593.1.
DR   RefSeq; XP_005160437.1; XM_005160380.3.
DR   AlphaFoldDB; Q5PR98; -.
DR   SMR; Q5PR98; -.
DR   STRING; 7955.ENSDARP00000012950; -.
DR   ESTHER; danre-ndrg2; Ndr_family.
DR   PaxDb; Q5PR98; -.
DR   PRIDE; Q5PR98; -.
DR   Ensembl; ENSDART00000019949; ENSDARP00000012950; ENSDARG00000011170.
DR   Ensembl; ENSDART00000165021; ENSDARP00000132699; ENSDARG00000011170.
DR   GeneID; 494050; -.
DR   KEGG; dre:494050; -.
DR   CTD; 57447; -.
DR   ZFIN; ZDB-GENE-041212-15; ndrg2.
DR   eggNOG; KOG2931; Eukaryota.
DR   GeneTree; ENSGT00950000182872; -.
DR   HOGENOM; CLU_035361_1_0_1; -.
DR   InParanoid; Q5PR98; -.
DR   OMA; KTCFQPL; -.
DR   OrthoDB; 854690at2759; -.
DR   PhylomeDB; Q5PR98; -.
DR   TreeFam; TF313168; -.
DR   PRO; PR:Q5PR98; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000011170; Expressed in cardiac ventricle and 27 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR004142; NDRG.
DR   InterPro; IPR030690; NDRG2.
DR   PANTHER; PTHR11034; PTHR11034; 1.
DR   PANTHER; PTHR11034:SF17; PTHR11034:SF17; 1.
DR   Pfam; PF03096; Ndr; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Neurogenesis;
KW   Reference proteome; Wnt signaling pathway.
FT   CHAIN           1..368
FT                   /note="Protein NDRG2"
FT                   /id="PRO_0000238967"
FT   REGION          330..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   368 AA;  40468 MW;  DEAB47995F3CF3D6 CRC64;
     MTTEMQEIAI TEEKPLLPGQ SDAVKDAEIA ARILLDQGQE HTVETPHGVL HVTVHGSGNA
     RRPAILTIHD VGMDSKSCFS TLFRFEEMQE IVKNFTVVHI DAPGQEEGAA VYPAGYQYAS
     MDQVSEMLPA VLQFFNFRTI IGVGVGAGAY ILSRFTLNNP EAVEGLVLVN VDPNARGWMD
     WAAHKLSNLT SSLSDQIISH LFSQQELSAN TELIQTHRER ITKAPNLLNI ELFWKSYLGR
     RDLSLDRNNT FKCPVMLVVG DQAPYEEAAV ECNSKLDPTT TSFLKMADAG GMPQLTQPSK
     LTEAFKYFIQ GMGYMASSCM TRLSRSRTTS LSSSYSMEGS RSRSRTLSQG SQGGQLPPSP
     SNTMEVSC