ID   NDRG2_PONAB             Reviewed;         371 AA.
AC   Q5RBN6; Q5R695; Q5R6V9;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Protein NDRG2;
DE   AltName: Full=N-myc downstream-regulated gene 2 protein;
GN   Name=NDRG2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain cortex, and Liver;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Contributes to the regulation of the Wnt signaling pathway.
CC       Down-regulates CTNNB1-mediated transcriptional activation of target
CC       genes, such as CCND1, and may thereby act as tumor suppressor. May be
CC       involved in dendritic cell and neuron differentiation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CTNNB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear
CC       region {ECO:0000250}. Cell projection, growth cone {ECO:0000250}.
CC       Note=In neurons, seems to concentrate at axonal growth cone.
CC       Perinuclear in neurons (By similarity). {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5RBN6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5RBN6-2; Sequence=VSP_019031;
CC   -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000305}.
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DR   EMBL; CR858602; CAH90824.1; -; mRNA.
DR   EMBL; CR860373; CAH92501.1; -; mRNA.
DR   EMBL; CR860599; CAH92721.1; -; mRNA.
DR   RefSeq; NP_001127578.1; NM_001134106.1. [Q5RBN6-2]
DR   RefSeq; NP_001128787.1; NM_001135315.1.
DR   RefSeq; XP_009247115.1; XM_009248840.1. [Q5RBN6-1]
DR   RefSeq; XP_009247116.1; XM_009248841.1.
DR   RefSeq; XP_009247117.1; XM_009248842.1.
DR   RefSeq; XP_009247119.1; XM_009248844.1. [Q5RBN6-2]
DR   RefSeq; XP_009247120.1; XM_009248845.1.
DR   RefSeq; XP_009247121.1; XM_009248846.1.
DR   RefSeq; XP_009247122.1; XM_009248847.1.
DR   RefSeq; XP_009247123.1; XM_009248848.1.
DR   RefSeq; XP_009247124.1; XM_009248849.1. [Q5RBN6-2]
DR   AlphaFoldDB; Q5RBN6; -.
DR   SMR; Q5RBN6; -.
DR   STRING; 9601.ENSPPYP00000006352; -.
DR   ESTHER; ponab-ndrg2; Ndr_family.
DR   MEROPS; S33.989; -.
DR   Ensembl; ENSPPYT00000006607; ENSPPYP00000006352; ENSPPYG00000005584. [Q5RBN6-1]
DR   GeneID; 100174656; -.
DR   GeneID; 100189690; -.
DR   KEGG; pon:100189690; -.
DR   CTD; 57447; -.
DR   eggNOG; KOG2931; Eukaryota.
DR   GeneTree; ENSGT00950000182872; -.
DR   InParanoid; Q5RBN6; -.
DR   OrthoDB; 854690at2759; -.
DR   Proteomes; UP000001595; Chromosome 14.
DR   GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR004142; NDRG.
DR   InterPro; IPR030690; NDRG2.
DR   PANTHER; PTHR11034; PTHR11034; 1.
DR   PANTHER; PTHR11034:SF17; PTHR11034:SF17; 1.
DR   Pfam; PF03096; Ndr; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Alternative splicing; Cell projection; Cytoplasm;
KW   Developmental protein; Differentiation; Neurogenesis; Phosphoprotein;
KW   Reference proteome; Tumor suppressor; Wnt signaling pathway.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN36"
FT   CHAIN           2..371
FT                   /note="Protein NDRG2"
FT                   /id="PRO_0000441170"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN36"
FT   MOD_RES         20
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN36"
FT   MOD_RES         326
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN36"
FT   MOD_RES         328
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN36"
FT   MOD_RES         330
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QYG0"
FT   MOD_RES         332
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QYG0"
FT   MOD_RES         334
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN36"
FT   MOD_RES         335
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QYG0"
FT   MOD_RES         338
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN36"
FT   MOD_RES         344
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UN36"
FT   MOD_RES         348
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QYG0"
FT   MOD_RES         350
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QYG0"
FT   MOD_RES         352
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QYG0"
FT   MOD_RES         353
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QYG0"
FT   MOD_RES         355
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QYG0"
FT   MOD_RES         357
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QYG0"
FT   MOD_RES         370
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QYG0"
FT   VAR_SEQ         26..39
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_019031"
FT   CONFLICT        188
FT                   /note="G -> D (in Ref. 1; CAH90824)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        359
FT                   /note="S -> P (in Ref. 1; CAH92501)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   371 AA;  40770 MW;  2B49B0A82BD97BBE CRC64;
     MAELQEVQIT EEKPLLPGQT PEAAKEAELA ARILLDQGQT HSVETPYGSV TFTVYGTPKP
     KRPAILTYHD VGLNYKSCFQ PLFQFEDMQE IIQNFVRVHV DAPGMEEGAP VFPLGYQYPS
     LDQLADMIPC VLQYLNFSTI IGVGVGAGAY ILARYALNHP DTVEGLVLIN IDPNAKGWMD
     WAAHKLTGLT SSIPEMILGH LFSQEELSGN SELIQKYRNI ITHAPNLDNI ELYWNSYNNR
     RDLNFERGGD ITLKCPVMLV VGDQAPHEDA VVECNSKLDP TQTSFLKMAD SGGQPQLTQP
     GKLTEAFKYF LQGMGYMASS CMTRLSRSRT ASLTSAASVD GNRSRSRTLS QSSESGTLSS
     GPPGHTMEVS C