ID   NDRG2_XENLA             Reviewed;         360 AA.
AC   Q7ZY73;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Protein NDRG2;
GN   Name=ndrg2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH43915.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH43915.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Contributes to the regulation of the Wnt signaling pathway.
CC       Down-regulates CTNNB1-mediated transcriptional activation of target
CC       genes. May be involved in neuron differentiation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000255}.
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DR   EMBL; BC043915; AAH43915.1; -; mRNA.
DR   RefSeq; NP_001080389.1; NM_001086920.1.
DR   AlphaFoldDB; Q7ZY73; -.
DR   SMR; Q7ZY73; -.
DR   ESTHER; xenla-ndrg2; Ndr_family.
DR   DNASU; 380081; -.
DR   GeneID; 380081; -.
DR   KEGG; xla:380081; -.
DR   CTD; 380081; -.
DR   Xenbase; XB-GENE-951915; ndrg2.S.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 380081; Expressed in brain and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR004142; NDRG.
DR   InterPro; IPR030690; NDRG2.
DR   PANTHER; PTHR11034; PTHR11034; 1.
DR   PANTHER; PTHR11034:SF17; PTHR11034:SF17; 1.
DR   Pfam; PF03096; Ndr; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Neurogenesis;
KW   Reference proteome; Wnt signaling pathway.
FT   CHAIN           1..360
FT                   /note="Protein NDRG2"
FT                   /id="PRO_0000232428"
FT   REGION          324..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..349
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   360 AA;  39386 MW;  3A301D773A0B598A CRC64;
     MSELHEVQIT EDNPLLQDPL KAAELAAKLL QVQEQKHSIE TPYGVVTVTI QGTPKPKRPA
     IVTFHDVGMD HKMCFDTLFK YEDMCEIVKN FVVCHIDAPG QEDGATIYPP GYQYPSLDQL
     AETIPCVLQY LNFPSIIGIG VGAGAYIFAK YTLSHANTVE GLVLINIDPN AKGWMDWAAQ
     KLTGLTQSIS DKMLGHLFSA EEISGNSDVV RQYKASISNS PLISNYQLYW NSYNSRRDLN
     FERGGGVTLK CPVMLVVGDQ APHEDAVVEC NSKLDPTQTS FLKMADSGGQ PQITQPGKMT
     EAFKYFVQGM GYMASSVMTR LSRSRTASLS SEGNRSRSRT LSQSSESGGG PPAPLAEVTC