ID   NDRG2_XENTR             Reviewed;         360 AA.
AC   Q66KM2;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Protein NDRG2;
GN   Name=ndrg2 {ECO:0000312|EMBL:AAH80333.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH80333.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH80333.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Contributes to the regulation of the Wnt signaling pathway.
CC       Down-regulates CTNNB1-mediated transcriptional activation of target
CC       genes. May be involved in neuron differentiation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000255}.
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DR   EMBL; BC080333; AAH80333.1; -; mRNA.
DR   RefSeq; NP_001007898.1; NM_001007897.1.
DR   AlphaFoldDB; Q66KM2; -.
DR   SMR; Q66KM2; -.
DR   STRING; 8364.ENSXETP00000035239; -.
DR   ESTHER; xentr-ndrg2; Ndr_family.
DR   MEROPS; S33.989; -.
DR   PaxDb; Q66KM2; -.
DR   DNASU; 493281; -.
DR   GeneID; 493281; -.
DR   KEGG; xtr:493281; -.
DR   CTD; 57447; -.
DR   Xenbase; XB-GENE-951910; ndrg2.
DR   eggNOG; KOG2931; Eukaryota.
DR   HOGENOM; CLU_035361_1_0_1; -.
DR   InParanoid; Q66KM2; -.
DR   OMA; KTCFQPL; -.
DR   OrthoDB; 854690at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   ExpressionAtlas; Q66KM2; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR004142; NDRG.
DR   InterPro; IPR030690; NDRG2.
DR   PANTHER; PTHR11034; PTHR11034; 1.
DR   PANTHER; PTHR11034:SF17; PTHR11034:SF17; 1.
DR   Pfam; PF03096; Ndr; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Neurogenesis;
KW   Reference proteome; Wnt signaling pathway.
FT   CHAIN           1..360
FT                   /note="Protein NDRG2"
FT                   /id="PRO_0000232429"
FT   REGION          325..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..349
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   360 AA;  39344 MW;  61757408DDC51EAA CRC64;
     MSELQEVQIT EDNPLLQDPL KAAELAAKLL QVQEQKHSIE TPYGVVTVTI QGTPKPKRPA
     IVTFHDVGMD HKMCFDTLFK YEDMCEIVKN FVVCHIDAPG QEEGSAVYPP GYQYPSLDQL
     AETIPCVLQY LNFPSIIGIG VGAGAYIFAK YTLSHANTVE GLVLINIDPN AKGWMDWAAQ
     KLTGLTQSIS DMMLGHLFSA EELSGNSDVV RQYKASILNS PLISNYQLYW NSYNSRRDLN
     LERGGGVTLK CPVMLVVGDQ APHEDAVVEC NSKLDPTQTS FLKMADSGGQ PQITQPGKLT
     EAFKYFVQGM GYMASSCMTR LSRSRTASLS SEGNRSRSRT LSQSSESGGG PPAPLAEVTC