NDRG3_HUMAN
ID NDRG3_HUMAN Reviewed; 375 AA.
AC Q9UGV2; A2A2S8; E1P5U7; E1P5U8; Q5TH32; Q96PL8; Q96SM2; Q9BXY7; Q9H3N7;
AC Q9H411; Q9H8J6;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Protein NDRG3;
DE AltName: Full=N-myc downstream-regulated gene 3 protein;
GN Name=NDRG3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=11352569; DOI=10.1006/geno.2000.6496;
RA Zhou R.-H., Kokame K., Tsukamoto Y., Yutani C., Kato H., Miyata T.;
RT "Characterization of the human NDRG gene family: a newly identified member,
RT NDRG4, is specifically expressed in brain and heart.";
RL Genomics 73:86-97(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Mao Y., Xie Y., Zhou Z., Zhao W., Zhao S., Wang W., Huang Y., Wang S.,
RA Tang R., Chen X., Wu C.;
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Spleen;
RX PubMed=11936845; DOI=10.1023/a:1017934810825;
RA Qu X., Zhai Y., Wei H., Zhang C., Xing G., Yu Y., He F.;
RT "Characterization and expression of three novel differentiation-related
RT genes belong to the human NDRG gene family.";
RL Mol. Cell. Biochem. 229:35-44(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Placenta, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-322; SER-335; SER-352 AND
RP SER-374, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331 AND SER-335, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [13]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [14]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [15]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [16]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-329; SER-331; THR-332;
RP SER-334; SER-335; SER-338; SER-341 AND THR-355, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [17]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9UGV2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UGV2-2; Sequence=VSP_003419;
CC Name=3;
CC IsoId=Q9UGV2-3; Sequence=VSP_003420;
CC -!- TISSUE SPECIFICITY: Ubiquitous. Highly expressed in brain.
CC {ECO:0000269|PubMed:11352569}.
CC -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB044943; BAB20067.1; -; mRNA.
DR EMBL; AF251054; AAK34944.1; -; mRNA.
DR EMBL; AF308609; AAL08807.1; -; mRNA.
DR EMBL; AK023618; BAB14620.1; -; mRNA.
DR EMBL; AK027665; BAB55277.1; -; mRNA.
DR EMBL; AL031662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL132768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW76112.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW76109.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW76114.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW76115.1; -; Genomic_DNA.
DR EMBL; BC136489; AAI36490.1; -; mRNA.
DR CCDS; CCDS13284.1; -. [Q9UGV2-2]
DR CCDS; CCDS13285.1; -. [Q9UGV2-1]
DR RefSeq; NP_071922.2; NM_022477.3. [Q9UGV2-2]
DR RefSeq; NP_114402.1; NM_032013.3. [Q9UGV2-1]
DR RefSeq; XP_016883468.1; XM_017027979.1. [Q9UGV2-1]
DR PDB; 6L4B; X-ray; 2.20 A; A/B/C/D/E/F=1-375.
DR PDB; 6L4G; X-ray; 3.30 A; A/B=1-375.
DR PDB; 6L4H; X-ray; 3.40 A; A/B/C/D=1-375.
DR PDBsum; 6L4B; -.
DR PDBsum; 6L4G; -.
DR PDBsum; 6L4H; -.
DR AlphaFoldDB; Q9UGV2; -.
DR SMR; Q9UGV2; -.
DR BioGRID; 121519; 29.
DR IntAct; Q9UGV2; 7.
DR MINT; Q9UGV2; -.
DR STRING; 9606.ENSP00000345292; -.
DR ESTHER; human-NDRG3; Ndr_family.
DR MEROPS; S33.987; -.
DR GlyGen; Q9UGV2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9UGV2; -.
DR PhosphoSitePlus; Q9UGV2; -.
DR BioMuta; NDRG3; -.
DR DMDM; 20141613; -.
DR EPD; Q9UGV2; -.
DR jPOST; Q9UGV2; -.
DR MassIVE; Q9UGV2; -.
DR MaxQB; Q9UGV2; -.
DR PaxDb; Q9UGV2; -.
DR PeptideAtlas; Q9UGV2; -.
DR PRIDE; Q9UGV2; -.
DR ProteomicsDB; 84267; -. [Q9UGV2-1]
DR ProteomicsDB; 84268; -. [Q9UGV2-2]
DR ProteomicsDB; 84269; -. [Q9UGV2-3]
DR Antibodypedia; 11784; 144 antibodies from 29 providers.
DR DNASU; 57446; -.
DR Ensembl; ENST00000349004.6; ENSP00000345292.1; ENSG00000101079.21. [Q9UGV2-1]
DR Ensembl; ENST00000359675.6; ENSP00000352703.2; ENSG00000101079.21. [Q9UGV2-2]
DR GeneID; 57446; -.
DR KEGG; hsa:57446; -.
DR MANE-Select; ENST00000349004.6; ENSP00000345292.1; NM_032013.4; NP_114402.1.
DR UCSC; uc002xfw.4; human. [Q9UGV2-1]
DR CTD; 57446; -.
DR DisGeNET; 57446; -.
DR GeneCards; NDRG3; -.
DR HGNC; HGNC:14462; NDRG3.
DR HPA; ENSG00000101079; Tissue enhanced (retina).
DR MIM; 605273; gene.
DR neXtProt; NX_Q9UGV2; -.
DR OpenTargets; ENSG00000101079; -.
DR PharmGKB; PA31484; -.
DR VEuPathDB; HostDB:ENSG00000101079; -.
DR eggNOG; KOG2931; Eukaryota.
DR GeneTree; ENSGT00950000182872; -.
DR HOGENOM; CLU_035361_1_0_1; -.
DR InParanoid; Q9UGV2; -.
DR PhylomeDB; Q9UGV2; -.
DR TreeFam; TF313168; -.
DR PathwayCommons; Q9UGV2; -.
DR SignaLink; Q9UGV2; -.
DR BioGRID-ORCS; 57446; 46 hits in 1080 CRISPR screens.
DR ChiTaRS; NDRG3; human.
DR GenomeRNAi; 57446; -.
DR Pharos; Q9UGV2; Tbio.
DR PRO; PR:Q9UGV2; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9UGV2; protein.
DR Bgee; ENSG00000101079; Expressed in cerebellar vermis and 205 other tissues.
DR ExpressionAtlas; Q9UGV2; baseline and differential.
DR Genevisible; Q9UGV2; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; NAS:UniProtKB.
DR GO; GO:0030308; P:negative regulation of cell growth; NAS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; NAS:UniProtKB.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004142; NDRG.
DR InterPro; IPR030692; NDRG3.
DR PANTHER; PTHR11034; PTHR11034; 1.
DR PANTHER; PTHR11034:SF20; PTHR11034:SF20; 1.
DR Pfam; PF03096; Ndr; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Alternative splicing; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..375
FT /note="Protein NDRG3"
FT /id="PRO_0000159577"
FT REGION 326..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:19413330,
FT ECO:0007744|PubMed:22814378"
FT MOD_RES 322
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 329
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 331
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569"
FT MOD_RES 332
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 334
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 335
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163"
FT MOD_RES 338
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 341
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 352
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 355
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 361
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9QYF9"
FT MOD_RES 374
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VAR_SEQ 20..31
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2"
FT /id="VSP_003419"
FT VAR_SEQ 47..135
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_003420"
FT CONFLICT 32
FT /note="E -> G (in Ref. 3; AAL08807)"
FT /evidence="ECO:0000305"
FT CONFLICT 71
FT /note="F -> S (in Ref. 4; BAB55277)"
FT /evidence="ECO:0000305"
FT CONFLICT 122
FT /note="P -> S (in Ref. 2; AAK34944)"
FT /evidence="ECO:0000305"
FT STRAND 31..37
FT /evidence="ECO:0007829|PDB:6L4B"
FT STRAND 40..48
FT /evidence="ECO:0007829|PDB:6L4B"
FT STRAND 52..54
FT /evidence="ECO:0007829|PDB:6L4B"
FT STRAND 56..60
FT /evidence="ECO:0007829|PDB:6L4B"
FT HELIX 67..75
FT /evidence="ECO:0007829|PDB:6L4B"
FT HELIX 78..84
FT /evidence="ECO:0007829|PDB:6L4B"
FT STRAND 89..93
FT /evidence="ECO:0007829|PDB:6L4B"
FT TURN 95..97
FT /evidence="ECO:0007829|PDB:6L4B"
FT HELIX 113..118
FT /evidence="ECO:0007829|PDB:6L4B"
FT HELIX 120..126
FT /evidence="ECO:0007829|PDB:6L4B"
FT STRAND 132..137
FT /evidence="ECO:0007829|PDB:6L4B"
FT HELIX 139..150
FT /evidence="ECO:0007829|PDB:6L4B"
FT TURN 152..154
FT /evidence="ECO:0007829|PDB:6L4B"
FT STRAND 155..162
FT /evidence="ECO:0007829|PDB:6L4B"
FT STRAND 173..176
FT /evidence="ECO:0007829|PDB:6L4H"
FT HELIX 185..193
FT /evidence="ECO:0007829|PDB:6L4B"
FT HELIX 196..201
FT /evidence="ECO:0007829|PDB:6L4B"
FT HELIX 204..215
FT /evidence="ECO:0007829|PDB:6L4B"
FT HELIX 219..230
FT /evidence="ECO:0007829|PDB:6L4B"
FT STRAND 254..261
FT /evidence="ECO:0007829|PDB:6L4B"
FT HELIX 267..275
FT /evidence="ECO:0007829|PDB:6L4B"
FT TURN 279..281
FT /evidence="ECO:0007829|PDB:6L4B"
FT STRAND 282..289
FT /evidence="ECO:0007829|PDB:6L4B"
FT HELIX 294..297
FT /evidence="ECO:0007829|PDB:6L4B"
FT HELIX 299..312
FT /evidence="ECO:0007829|PDB:6L4B"
FT STRAND 315..318
FT /evidence="ECO:0007829|PDB:6L4G"
SQ SEQUENCE 375 AA; 41409 MW; 237B6DF43AAB7F1E CRC64;
MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETTHG VVHVTIRGLP KGNRPVILTY
HDIGLNHKSC FNAFFNFEDM QEITQHFAVC HVDAPGQQEG APSFPTGYQY PTMDELAEML
PPVLTHLSLK SIIGIGVGAG AYILSRFALN HPELVEGLVL INVDPCAKGW IDWAASKLSG
LTTNVVDIIL AHHFGQEELQ ANLDLIQTYR MHIAQDINQD NLQLFLNSYN GRRDLEIERP
ILGQNDNKSK TLKCSTLLVV GDNSPAVEAV VECNSRLNPI NTTLLKMADC GGLPQVVQPG
KLTEAFKYFL QGMGYIPSAS MTRLARSRTH STSSSLGSGE SPFSRSVTSN QSDGTQESCE
SPDVLDRHQT MEVSC
