NDRG3_MOUSE
ID NDRG3_MOUSE Reviewed; 375 AA.
AC Q9QYF9;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Protein NDRG3;
DE AltName: Full=N-myc downstream-regulated gene 3 protein;
DE AltName: Full=Protein Ndr3;
GN Name=Ndrg3; Synonyms=Ndr3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=10581191; DOI=10.1006/bbrc.1999.1780;
RA Okuda T., Kondoh H.;
RT "Identification of new genes ndr2 and ndr3 which are related to
RT Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc.";
RL Biochem. Biophys. Res. Commun. 266:208-215(1999).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331; SER-334 AND SER-335, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-329; SER-331; SER-334;
RP SER-335; SER-338; SER-341 AND SER-361, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=21636852; DOI=10.1074/jbc.m111.256446;
RA Yamamoto H., Kokame K., Okuda T., Nakajo Y., Yanamoto H., Miyata T.;
RT "NDRG4 protein-deficient mice exhibit spatial learning deficits and
RT vulnerabilities to cerebral ischemia.";
RL J. Biol. Chem. 286:26158-26165(2011).
CC -!- TISSUE SPECIFICITY: Expressed at high levels in brain, followed by
CC small intestine and kidney (at protein level). Also expressed in
CC thymus. {ECO:0000269|PubMed:21636852}.
CC -!- DEVELOPMENTAL STAGE: Its expression is already significant at 9.5 dpc,
CC covering the entire embryo except the heart, and it shows only a slight
CC increase in later developmental stages.
CC -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000305}.
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DR EMBL; AB033922; BAA85883.1; -; mRNA.
DR CCDS; CCDS16971.1; -.
DR RefSeq; NP_038893.1; NM_013865.2.
DR RefSeq; XP_017174456.1; XM_017318967.1.
DR RefSeq; XP_017174457.1; XM_017318968.1.
DR AlphaFoldDB; Q9QYF9; -.
DR SMR; Q9QYF9; -.
DR BioGRID; 205893; 3.
DR STRING; 10090.ENSMUSP00000070052; -.
DR ESTHER; mouse-ndr3; Ndr_family.
DR iPTMnet; Q9QYF9; -.
DR PhosphoSitePlus; Q9QYF9; -.
DR EPD; Q9QYF9; -.
DR jPOST; Q9QYF9; -.
DR MaxQB; Q9QYF9; -.
DR PaxDb; Q9QYF9; -.
DR PRIDE; Q9QYF9; -.
DR ProteomicsDB; 287462; -.
DR Antibodypedia; 11784; 144 antibodies from 29 providers.
DR DNASU; 29812; -.
DR Ensembl; ENSMUST00000072298; ENSMUSP00000072144; ENSMUSG00000027634.
DR GeneID; 29812; -.
DR KEGG; mmu:29812; -.
DR UCSC; uc008nof.2; mouse.
DR CTD; 57446; -.
DR MGI; MGI:1352499; Ndrg3.
DR VEuPathDB; HostDB:ENSMUSG00000027634; -.
DR eggNOG; KOG2931; Eukaryota.
DR GeneTree; ENSGT00950000182872; -.
DR HOGENOM; CLU_035361_1_0_1; -.
DR InParanoid; Q9QYF9; -.
DR PhylomeDB; Q9QYF9; -.
DR BioGRID-ORCS; 29812; 18 hits in 71 CRISPR screens.
DR ChiTaRS; Ndrg3; mouse.
DR PRO; PR:Q9QYF9; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9QYF9; protein.
DR Bgee; ENSMUSG00000027634; Expressed in retinal neural layer and 268 other tissues.
DR ExpressionAtlas; Q9QYF9; baseline and differential.
DR Genevisible; Q9QYF9; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004142; NDRG.
DR InterPro; IPR030692; NDRG3.
DR PANTHER; PTHR11034; PTHR11034; 1.
DR PANTHER; PTHR11034:SF20; PTHR11034:SF20; 1.
DR Pfam; PF03096; Ndr; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Acetylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..375
FT /note="Protein NDRG3"
FT /id="PRO_0000159578"
FT REGION 326..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9UGV2"
FT MOD_RES 322
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UGV2"
FT MOD_RES 329
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 331
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 332
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UGV2"
FT MOD_RES 334
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 335
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 338
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 341
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 352
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UGV2"
FT MOD_RES 355
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UGV2"
FT MOD_RES 361
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 374
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UGV2"
SQ SEQUENCE 375 AA; 41555 MW; B33D3CC3E816AEA1 CRC64;
MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETPHG MVHVTIRGLP KGNRPVILTY
HDIGLNHKSC FNTFFNFEDM QEITQHFAVC HVDAPGQQEA APSFPTGYQY PTMDELAEML
PPVLTHLSMK SIIGIGVGAG AYILSRFALN HPELVEGLVL INIDPCAKGW IDWAASKLSG
FTTNIVDIIL AHHFGQEELQ ANLDLIQTYR LHIAQDINQE NLQLFLGSYN GRRDLEIERP
ILGQNDNRLK TLKCSTLLVV GDNSPAVEAV VECNSRLDPI NTTLLKMADC GGLPQVVQPG
KLTEAFKYFL QGMGYIPSAS MTRLARSRTH STSSSIGSGE SPFSRSVTSN QSDGTQESCE
SPDVLDRHQT MEVSC
