ID   NDRG3_RAT               Reviewed;         375 AA.
AC   Q6AYR2;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Protein NDRG3;
DE   AltName: Full=N-myc downstream-regulated gene 3 protein;
GN   Name=Ndrg3; Synonyms=Ndr3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338 AND SER-341, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000305}.
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DR   EMBL; BC078946; AAH78946.1; -; mRNA.
DR   RefSeq; NP_001013945.1; NM_001013923.1.
DR   AlphaFoldDB; Q6AYR2; -.
DR   SMR; Q6AYR2; -.
DR   STRING; 10116.ENSRNOP00000052106; -.
DR   ESTHER; ratno-q6ayr2; Ndr_family.
DR   iPTMnet; Q6AYR2; -.
DR   PhosphoSitePlus; Q6AYR2; -.
DR   jPOST; Q6AYR2; -.
DR   PaxDb; Q6AYR2; -.
DR   PRIDE; Q6AYR2; -.
DR   Ensembl; ENSRNOT00000103585; ENSRNOP00000087669; ENSRNOG00000036813.
DR   Ensembl; ENSRNOT00000109829; ENSRNOP00000086721; ENSRNOG00000036813.
DR   GeneID; 296318; -.
DR   KEGG; rno:296318; -.
DR   UCSC; RGD:1359424; rat.
DR   CTD; 57446; -.
DR   RGD; 1359424; Ndrg3.
DR   eggNOG; KOG2931; Eukaryota.
DR   GeneTree; ENSGT00950000182872; -.
DR   InParanoid; Q6AYR2; -.
DR   OrthoDB; 854690at2759; -.
DR   PhylomeDB; Q6AYR2; -.
DR   PRO; PR:Q6AYR2; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR004142; NDRG.
DR   InterPro; IPR030692; NDRG3.
DR   PANTHER; PTHR11034; PTHR11034; 1.
DR   PANTHER; PTHR11034:SF20; PTHR11034:SF20; 1.
DR   Pfam; PF03096; Ndr; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Phosphoprotein; Reference proteome.
FT   CHAIN           1..375
FT                   /note="Protein NDRG3"
FT                   /id="PRO_0000357054"
FT   REGION          326..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        326..359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UGV2"
FT   MOD_RES         322
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UGV2"
FT   MOD_RES         329
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UGV2"
FT   MOD_RES         331
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UGV2"
FT   MOD_RES         332
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UGV2"
FT   MOD_RES         334
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UGV2"
FT   MOD_RES         335
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UGV2"
FT   MOD_RES         338
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         341
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         352
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UGV2"
FT   MOD_RES         355
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UGV2"
FT   MOD_RES         361
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QYF9"
FT   MOD_RES         374
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UGV2"
SQ   SEQUENCE   375 AA;  41507 MW;  3B1E31AE9E4E9762 CRC64;
     MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETPHG MVHVTIRGLP KGNRPVILTY
     HDIGLNHKSC FNTFFNFEDM QEITQHFAVC HVDAPGQQEA APSFPTGYQY PTMDELAEML
     PPVLTHLSMK SIIGIGVGAG AYILSRFALN HPELVEGLVL INIDPCAKGW IDWAASKLSG
     LTTNVVDIIL AHHFGQEELQ ANLDLIQTYR LHIAQDINQE NLQLFLGSYN GRRDLEIERP
     ILGQNDNRLK TLKCSTLLVV GDNSPAVEAV VECNSRLDPI NTTLLKMADC GGLPQVVQPG
     KLTEAFKYFL QGMGYIPSAS MTRLARSRTH STSSSIGSGE SPFSRSVTSN QSDGTQESCE
     SPDVLDRHQT MEVSC