NDRG4_HUMAN
ID NDRG4_HUMAN Reviewed; 352 AA.
AC Q9ULP0; B3KNU2; B4DK66; B4DSW5; H7C600; Q6ZNE7; Q6ZTI7; Q96PL9; Q9GZM1;
AC Q9GZN3; Q9GZX0;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Protein NDRG4;
DE AltName: Full=Brain development-related molecule 1;
DE AltName: Full=N-myc downstream-regulated gene 4 protein;
DE AltName: Full=Vascular smooth muscle cell-associated protein 8;
DE Short=SMAP-8;
GN Name=NDRG4; Synonyms=BDM1, KIAA1180;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, AND TISSUE
RP SPECIFICITY.
RX PubMed=11352569; DOI=10.1006/geno.2000.6496;
RA Zhou R.-H., Kokame K., Tsukamoto Y., Yutani C., Kato H., Miyata T.;
RT "Characterization of the human NDRG gene family: a newly identified member,
RT NDRG4, is specifically expressed in brain and heart.";
RL Genomics 73:86-97(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
RC TISSUE=Spleen;
RX PubMed=11936845; DOI=10.1023/a:1017934810825;
RA Qu X., Zhai Y., Wei H., Zhang C., Xing G., Yu Y., He F.;
RT "Characterization and expression of three novel differentiation-related
RT genes belong to the human NDRG gene family.";
RL Mol. Cell. Biochem. 229:35-44(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION,
RP PHOSPHORYLATION, AND TISSUE SPECIFICITY.
RC TISSUE=Heart;
RX PubMed=12755708; DOI=10.1046/j.1432-1033.2003.03626.x;
RA Nishimoto S., Tawara J., Toyoda H., Kitamura K., Komurasaki T.;
RT "A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat
RT vascular smooth muscle cells.";
RL Eur. J. Biochem. 270:2521-2531(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Amygdala;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 5; 6; 7 AND 8).
RC TISSUE=Brain, Cerebellum, Hippocampus, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-352 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT "Characterization of cDNA clones selected by the GeneMark analysis from
RT size-fractionated cDNA libraries from human brain.";
RL DNA Res. 6:329-336(1999).
RN [9]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [10]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=19592488; DOI=10.1074/jbc.m109.012484;
RA Schilling S.H., Hjelmeland A.B., Radiloff D.R., Liu I.M., Wakeman T.P.,
RA Fielhauer J.R., Foster E.H., Lathia J.D., Rich J.N., Wang X.F., Datto M.B.;
RT "NDRG4 is required for cell cycle progression and survival in glioblastoma
RT cells.";
RL J. Biol. Chem. 284:25160-25169(2009).
CC -!- FUNCTION: Contributes to the maintenance of intracerebral BDNF levels
CC within the normal range, which is necessary for the preservation of
CC spatial learning and the resistance to neuronal cell death caused by
CC ischemic stress (By similarity). May enhance growth factor-induced ERK1
CC and ERK2 phosphorylation, including that induced by PDGF and FGF. May
CC attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent
CC manner. {ECO:0000250, ECO:0000269|PubMed:12755708}.
CC -!- INTERACTION:
CC Q9ULP0; Q6RW13: AGTRAP; NbExp=3; IntAct=EBI-10323810, EBI-741181;
CC Q9ULP0; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-10323810, EBI-714543;
CC Q9ULP0; Q96DZ9: CMTM5; NbExp=3; IntAct=EBI-10323810, EBI-2548702;
CC Q9ULP0; Q9UI14: RABAC1; NbExp=3; IntAct=EBI-10323810, EBI-712367;
CC Q9ULP0-2; Q6RW13-2: AGTRAP; NbExp=6; IntAct=EBI-11978907, EBI-11522760;
CC Q9ULP0-2; P53365: ARFIP2; NbExp=3; IntAct=EBI-11978907, EBI-638194;
CC Q9ULP0-2; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-11978907, EBI-714543;
CC Q9ULP0-2; P18859: ATP5PF; NbExp=3; IntAct=EBI-11978907, EBI-2606700;
CC Q9ULP0-2; Q9UGQ2: CACFD1; NbExp=3; IntAct=EBI-11978907, EBI-8652492;
CC Q9ULP0-2; P51861: CDR1; NbExp=3; IntAct=EBI-11978907, EBI-2836538;
CC Q9ULP0-2; Q9UHD4: CIDEB; NbExp=3; IntAct=EBI-11978907, EBI-7062247;
CC Q9ULP0-2; Q96DZ9-2: CMTM5; NbExp=7; IntAct=EBI-11978907, EBI-11522780;
CC Q9ULP0-2; Q9NZJ6: COQ3; NbExp=3; IntAct=EBI-11978907, EBI-10897372;
CC Q9ULP0-2; Q6PUV4: CPLX2; NbExp=3; IntAct=EBI-11978907, EBI-2689453;
CC Q9ULP0-2; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-11978907, EBI-742054;
CC Q9ULP0-2; Q96Q80: DERL3; NbExp=3; IntAct=EBI-11978907, EBI-12831318;
CC Q9ULP0-2; Q6ZPD8: DGAT2L6; NbExp=3; IntAct=EBI-11978907, EBI-12831978;
CC Q9ULP0-2; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-11978907, EBI-781551;
CC Q9ULP0-2; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-11978907, EBI-17490413;
CC Q9ULP0-2; Q9H400: LIME1; NbExp=3; IntAct=EBI-11978907, EBI-2830566;
CC Q9ULP0-2; Q96AG4: LRRC59; NbExp=3; IntAct=EBI-11978907, EBI-358888;
CC Q9ULP0-2; Q969L2: MAL2; NbExp=8; IntAct=EBI-11978907, EBI-944295;
CC Q9ULP0-2; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-11978907, EBI-3923617;
CC Q9ULP0-2; Q04941: PLP2; NbExp=3; IntAct=EBI-11978907, EBI-608347;
CC Q9ULP0-2; O60831: PRAF2; NbExp=3; IntAct=EBI-11978907, EBI-2506064;
CC Q9ULP0-2; Q9UI14: RABAC1; NbExp=3; IntAct=EBI-11978907, EBI-712367;
CC Q9ULP0-2; Q96HR9-2: REEP6; NbExp=7; IntAct=EBI-11978907, EBI-14065960;
CC Q9ULP0-2; Q6NTF9-3: RHBDD2; NbExp=3; IntAct=EBI-11978907, EBI-17589229;
CC Q9ULP0-2; O95197-3: RTN3; NbExp=3; IntAct=EBI-11978907, EBI-11525735;
CC Q9ULP0-2; O15126: SCAMP1; NbExp=3; IntAct=EBI-11978907, EBI-954338;
CC Q9ULP0-2; Q8N3Y7: SDR16C5; NbExp=3; IntAct=EBI-11978907, EBI-3923480;
CC Q9ULP0-2; Q8WV19: SFT2D1; NbExp=3; IntAct=EBI-11978907, EBI-2854842;
CC Q9ULP0-2; O95562: SFT2D2; NbExp=3; IntAct=EBI-11978907, EBI-4402330;
CC Q9ULP0-2; O00141: SGK1; NbExp=3; IntAct=EBI-11978907, EBI-1042854;
CC Q9ULP0-2; H3BQL7: SIN3A; NbExp=3; IntAct=EBI-11978907, EBI-13384308;
CC Q9ULP0-2; O60906: SMPD2; NbExp=3; IntAct=EBI-11978907, EBI-12828299;
CC Q9ULP0-2; O43759-2: SYNGR1; NbExp=3; IntAct=EBI-11978907, EBI-12187159;
CC Q9ULP0-2; O43761: SYNGR3; NbExp=3; IntAct=EBI-11978907, EBI-11321949;
CC Q9ULP0-2; P08247: SYP; NbExp=3; IntAct=EBI-11978907, EBI-9071725;
CC Q9ULP0-2; Q8WY91: THAP4; NbExp=3; IntAct=EBI-11978907, EBI-726691;
CC Q9ULP0-2; Q9BTX3: TMEM208; NbExp=3; IntAct=EBI-11978907, EBI-12876824;
CC Q9ULP0-2; O95070: YIF1A; NbExp=3; IntAct=EBI-11978907, EBI-2799703;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12755708,
CC ECO:0000269|PubMed:19592488}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=8;
CC Name=1; Synonyms=NDRG4-BVar;
CC IsoId=Q9ULP0-1; Sequence=Displayed;
CC Name=2; Synonyms=NDRG4-B;
CC IsoId=Q9ULP0-2; Sequence=VSP_003422;
CC Name=3; Synonyms=NDRG4-H;
CC IsoId=Q9ULP0-3; Sequence=VSP_003421, VSP_003422;
CC Name=4;
CC IsoId=Q9ULP0-4; Sequence=VSP_003423;
CC Name=5;
CC IsoId=Q9ULP0-5; Sequence=VSP_022957, VSP_003422;
CC Name=6;
CC IsoId=Q9ULP0-6; Sequence=VSP_022956, VSP_003422;
CC Name=7;
CC IsoId=Q9ULP0-7; Sequence=VSP_045830, VSP_003422;
CC Name=8;
CC IsoId=Q9ULP0-8; Sequence=VSP_046326, VSP_003422;
CC -!- TISSUE SPECIFICITY: Expressed predominantly in brain and heart (at
CC protein level). In the brain, detected in astrocytes. Isoform 1 and
CC isoform 2 are only expressed in brain. Isoform 3 is expressed in both
CC heart and brain. Up-regulated in glioblastoma multiforme cells.
CC {ECO:0000269|PubMed:11352569, ECO:0000269|PubMed:12755708,
CC ECO:0000269|PubMed:19592488}.
CC -!- DEVELOPMENTAL STAGE: Expressed in a cell cycle-specific manner in
CC glioblastoma multiple cells. Low levels in G2/M cells increase with
CC progression through G1 phase and entry and progression through S phase.
CC {ECO:0000269|PubMed:19592488}.
CC -!- PTM: Phosphorylated in an aortic smooth muscle cell line, following
CC PDGF treatment. {ECO:0000269|PubMed:12755708}.
CC -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA86494.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB044947; BAB20071.1; -; Genomic_DNA.
DR EMBL; AB044947; BAB20072.1; -; Genomic_DNA.
DR EMBL; AB044947; BAB20073.1; -; Genomic_DNA.
DR EMBL; AB044944; BAB20068.1; -; mRNA.
DR EMBL; AB044945; BAB20069.1; -; mRNA.
DR EMBL; AB044946; BAB20070.1; -; mRNA.
DR EMBL; AF308608; AAL08806.1; -; mRNA.
DR EMBL; AB021172; BAB20288.1; -; mRNA.
DR EMBL; AL136584; CAB66519.1; -; mRNA.
DR EMBL; AK055038; BAG51454.1; -; mRNA.
DR EMBL; AK126574; BAC86600.1; -; mRNA.
DR EMBL; AK131248; BAD18428.1; -; mRNA.
DR EMBL; AK296415; BAG59078.1; -; mRNA.
DR EMBL; AK299949; BAG61777.1; -; mRNA.
DR EMBL; AC009118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC011795; AAH11795.1; -; mRNA.
DR EMBL; AB033006; BAA86494.2; ALT_INIT; mRNA.
DR CCDS; CCDS10797.1; -. [Q9ULP0-3]
DR CCDS; CCDS45500.1; -. [Q9ULP0-6]
DR CCDS; CCDS55999.1; -. [Q9ULP0-7]
DR CCDS; CCDS58465.1; -. [Q9ULP0-8]
DR CCDS; CCDS58466.1; -. [Q9ULP0-1]
DR CCDS; CCDS58467.1; -. [Q9ULP0-2]
DR RefSeq; NP_001123959.1; NM_001130487.1. [Q9ULP0-6]
DR RefSeq; NP_001229762.1; NM_001242833.1. [Q9ULP0-7]
DR RefSeq; NP_001229763.1; NM_001242834.1. [Q9ULP0-8]
DR RefSeq; NP_001229764.1; NM_001242835.1. [Q9ULP0-1]
DR RefSeq; NP_001229765.1; NM_001242836.1. [Q9ULP0-2]
DR RefSeq; NP_065198.1; NM_020465.3. [Q9ULP0-3]
DR RefSeq; NP_075061.1; NM_022910.3. [Q9ULP0-3]
DR RefSeq; XP_016879079.1; XM_017023590.1.
DR AlphaFoldDB; Q9ULP0; -.
DR SMR; Q9ULP0; -.
DR BioGRID; 122372; 52.
DR IntAct; Q9ULP0; 45.
DR MINT; Q9ULP0; -.
DR STRING; 9606.ENSP00000377823; -.
DR ESTHER; human-NDRG4; Ndr_family.
DR MEROPS; S33.986; -.
DR iPTMnet; Q9ULP0; -.
DR PhosphoSitePlus; Q9ULP0; -.
DR BioMuta; NDRG4; -.
DR DMDM; 20141614; -.
DR EPD; Q9ULP0; -.
DR jPOST; Q9ULP0; -.
DR MassIVE; Q9ULP0; -.
DR MaxQB; Q9ULP0; -.
DR PaxDb; Q9ULP0; -.
DR PeptideAtlas; Q9ULP0; -.
DR PRIDE; Q9ULP0; -.
DR ProteomicsDB; 4431; -.
DR ProteomicsDB; 46171; -.
DR ProteomicsDB; 85084; -. [Q9ULP0-1]
DR ProteomicsDB; 85085; -. [Q9ULP0-2]
DR ProteomicsDB; 85086; -. [Q9ULP0-3]
DR ProteomicsDB; 85087; -. [Q9ULP0-4]
DR ProteomicsDB; 85088; -. [Q9ULP0-5]
DR ProteomicsDB; 85089; -. [Q9ULP0-6]
DR TopDownProteomics; Q9ULP0-3; -. [Q9ULP0-3]
DR Antibodypedia; 2919; 303 antibodies from 33 providers.
DR DNASU; 65009; -.
DR Ensembl; ENST00000258187.9; ENSP00000258187.5; ENSG00000103034.15. [Q9ULP0-3]
DR Ensembl; ENST00000356752.8; ENSP00000349193.4; ENSG00000103034.15. [Q9ULP0-7]
DR Ensembl; ENST00000394279.6; ENSP00000377820.2; ENSG00000103034.15. [Q9ULP0-3]
DR Ensembl; ENST00000394282.8; ENSP00000377823.4; ENSG00000103034.15. [Q9ULP0-6]
DR Ensembl; ENST00000563799.5; ENSP00000458113.1; ENSG00000103034.15. [Q9ULP0-5]
DR Ensembl; ENST00000566192.5; ENSP00000454410.1; ENSG00000103034.15. [Q9ULP0-2]
DR Ensembl; ENST00000568640.5; ENSP00000456338.1; ENSG00000103034.15. [Q9ULP0-8]
DR Ensembl; ENST00000570248.6; ENSP00000457659.1; ENSG00000103034.15. [Q9ULP0-1]
DR GeneID; 65009; -.
DR KEGG; hsa:65009; -.
DR MANE-Select; ENST00000570248.6; ENSP00000457659.1; NM_001242835.2; NP_001229764.1.
DR UCSC; uc002enk.4; human. [Q9ULP0-1]
DR CTD; 65009; -.
DR DisGeNET; 65009; -.
DR GeneCards; NDRG4; -.
DR HGNC; HGNC:14466; NDRG4.
DR HPA; ENSG00000103034; Tissue enhanced (brain, heart muscle).
DR MIM; 614463; gene.
DR neXtProt; NX_Q9ULP0; -.
DR OpenTargets; ENSG00000103034; -.
DR PharmGKB; PA31485; -.
DR VEuPathDB; HostDB:ENSG00000103034; -.
DR eggNOG; KOG2931; Eukaryota.
DR GeneTree; ENSGT00950000182872; -.
DR HOGENOM; CLU_035361_1_0_1; -.
DR InParanoid; Q9ULP0; -.
DR OMA; CMADSGG; -.
DR OrthoDB; 854690at2759; -.
DR PhylomeDB; Q9ULP0; -.
DR TreeFam; TF313168; -.
DR PathwayCommons; Q9ULP0; -.
DR SignaLink; Q9ULP0; -.
DR BioGRID-ORCS; 65009; 8 hits in 1073 CRISPR screens.
DR ChiTaRS; NDRG4; human.
DR GeneWiki; NDRG4; -.
DR GenomeRNAi; 65009; -.
DR Pharos; Q9ULP0; Tbio.
DR PRO; PR:Q9ULP0; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q9ULP0; protein.
DR Bgee; ENSG00000103034; Expressed in right hemisphere of cerebellum and 153 other tissues.
DR ExpressionAtlas; Q9ULP0; baseline and differential.
DR Genevisible; Q9ULP0; HS.
DR GO; GO:0016323; C:basolateral plasma membrane; IDA:BHF-UCL.
DR GO; GO:0031253; C:cell projection membrane; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IDA:BHF-UCL.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:BHF-UCL.
DR GO; GO:0005739; C:mitochondrion; ISS:BHF-UCL.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; ISS:BHF-UCL.
DR GO; GO:0030154; P:cell differentiation; NAS:UniProtKB.
DR GO; GO:0060973; P:cell migration involved in heart development; IEA:Ensembl.
DR GO; GO:0035050; P:embryonic heart tube development; ISS:BHF-UCL.
DR GO; GO:0001947; P:heart looping; ISS:BHF-UCL.
DR GO; GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:BHF-UCL.
DR GO; GO:0014912; P:negative regulation of smooth muscle cell migration; IDA:BHF-UCL.
DR GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IDA:BHF-UCL.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL.
DR GO; GO:0010976; P:positive regulation of neuron projection development; ISS:BHF-UCL.
DR GO; GO:2001135; P:regulation of endocytic recycling; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0048278; P:vesicle docking; IEA:Ensembl.
DR GO; GO:0008542; P:visual learning; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004142; NDRG.
DR InterPro; IPR030695; NDRG4.
DR PANTHER; PTHR11034; PTHR11034; 1.
DR PANTHER; PTHR11034:SF21; PTHR11034:SF21; 1.
DR Pfam; PF03096; Ndr; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..352
FT /note="Protein NDRG4"
FT /id="PRO_0000159579"
FT REGION 314..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 298
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Z2L9"
FT MOD_RES 317
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Z2L9"
FT MOD_RES 323
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BTG7"
FT VAR_SEQ 1..7
FT /note="MPECWDG -> MAGLQELRFPEEKPLLRGQDATELESSDAFLLAADTDWK
FT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12755708"
FT /id="VSP_003421"
FT VAR_SEQ 1..7
FT /note="MPECWDG -> MKVLGHRLELLTGLLLHDVTMAGLQELRFPEEKPLLRGQDA
FT TELESSDAFLLAADTDWK (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_022956"
FT VAR_SEQ 7
FT /note="G -> GVGEGNAGAVKLAGLGDPRWSPGHLLSPGHQ (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045830"
FT VAR_SEQ 7
FT /note="G -> GRSQERRLPRVSSTVSPLQ (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046326"
FT VAR_SEQ 43
FT /note="H -> RKCSPASVSPPLPPISQSD (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_022957"
FT VAR_SEQ 289..302
FT /note="IAYLKDRRLSGGAV -> M (in isoform 2, isoform 3,
FT isoform 5, isoform 6, isoform 7 and isoform 8)"
FT /evidence="ECO:0000303|PubMed:11230166,
FT ECO:0000303|PubMed:12755708, ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_003422"
FT VAR_SEQ 291..303
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:11936845"
FT /id="VSP_003423"
FT CONFLICT 10
FT /note="D -> N (in Ref. 5; BAG61777)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 352 AA; 38459 MW; 4CFAFC7C820013B6 CRC64;
MPECWDGEHD IETPYGLLHV VIRGSPKGNR PAILTYHDVG LNHKLCFNTF FNFEDMQEIT
KHFVVCHVDA PGQQVGASQF PQGYQFPSME QLAAMLPSVV QHFGFKYVIG IGVGAGAYVL
AKFALIFPDL VEGLVLVNID PNGKGWIDWA ATKLSGLTST LPDTVLSHLF SQEELVNNTE
LVQSYRQQIG NVVNQANLQL FWNMYNSRRD LDINRPGTVP NAKTLRCPVM LVVGDNAPAE
DGVVECNSKL DPTTTTFLKM ADSGGLPQVT QPGKLTEAFK YFLQGMGYIA YLKDRRLSGG
AVPSASMTRL ARSRTASLTS ASSVDGSRPQ ACTHSESSEG LGQVNHTMEV SC
