ID   NDRG4_XENTR             Reviewed;         405 AA.
AC   Q6DIX1;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Protein NDRG4;
GN   Name=ndrg4 {ECO:0000312|EMBL:AAH75414.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH75414.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Contributes to the maintenance of intracerebral BDNF levels
CC       within the normal range. May enhance growth factor-induced ERK1 and
CC       ERK2 phosphorylation. May attenuate growth factor-promoted ELK1
CC       phosphorylation in a microtubule-dependent manner (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000255}.
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DR   EMBL; BC075414; AAH75414.1; -; mRNA.
DR   RefSeq; NP_001006704.1; NM_001006703.1.
DR   AlphaFoldDB; Q6DIX1; -.
DR   SMR; Q6DIX1; -.
DR   STRING; 8364.ENSXETP00000030072; -.
DR   ESTHER; xentr-ndrg4; Ndr_family.
DR   MEROPS; S33.986; -.
DR   PaxDb; Q6DIX1; -.
DR   DNASU; 448335; -.
DR   Ensembl; ENSXETT00000030072; ENSXETP00000030072; ENSXETG00000013742.
DR   GeneID; 448335; -.
DR   KEGG; xtr:448335; -.
DR   CTD; 65009; -.
DR   Xenbase; XB-GENE-941128; ndrg4.
DR   eggNOG; KOG2931; Eukaryota.
DR   HOGENOM; CLU_035361_1_0_1; -.
DR   InParanoid; Q6DIX1; -.
DR   OMA; CMADSGG; -.
DR   OrthoDB; 854690at2759; -.
DR   TreeFam; TF313168; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000013742; Expressed in brain and 16 other tissues.
DR   ExpressionAtlas; Q6DIX1; differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0007420; P:brain development; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR004142; NDRG.
DR   InterPro; IPR030695; NDRG4.
DR   PANTHER; PTHR11034; PTHR11034; 1.
DR   PANTHER; PTHR11034:SF21; PTHR11034:SF21; 1.
DR   Pfam; PF03096; Ndr; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..405
FT                   /note="Protein NDRG4"
FT                   /id="PRO_0000232434"
FT   REGION          352..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   405 AA;  44461 MW;  596D3BC4B14CBF74 CRC64;
     MKLLGHKIEL WAGLLLPDVS ISGMSELRFP EEKPLLRGQD TEMESADTFL SAADTDWKEH
     DIETPYGMLH VVIRGTPKGN RPAILTYHDV GLNHKLCFNT FFNYEDMQEI TKHFVVCHVD
     APGQQVGASQ FPQGYQYPTM EQLAAMLPSV MQHFGFQSII GIGVGAGAYV LAKFALIFPE
     LVEGMVLVNI DPNGKGWIDW AASKLSGLTS SLPETVLSHL FSQEELMNNT ELVQNYRQQI
     SSCVNQSNLQ LFWNMYNSRR DLEMSRPGTV PNAKTLRAPV MLVVGDNAPA EDCVVECNSK
     LDPTNTTFLK MADSGGLPQV TQPGKLTEAF KYFLQGMGYI ASLKDRRQSA SAGAVPSASM
     TRLARSRTAS LTSASSVDGA RPRPCTQSES SDGIGQINHT MEVSC