NDS5A_ARATH
ID NDS5A_ARATH Reviewed; 118 AA.
AC O82238; Q0WRL8;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-A;
GN OrderedLocusNames=At2g47690; ORFNames=F17A22.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 28-118.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Complex I is composed of at least 49 different subunits. This
CC is a component of the iron-sulfur (IP) fragment of the enzyme.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Mitochondrion inner
CC membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC Mitochondrion intermembrane space {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=O82238-1; Sequence=Displayed;
CC -!- DOMAIN: Contains two C-X9-C motifs that are predicted to form a helix-
CC coil-helix structure, permitting the formation of intramolecular
CC disulfide bonds. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I NDUFS5 subunit family.
CC {ECO:0000305}.
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DR EMBL; AC005309; AAC63625.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10876.1; -; Genomic_DNA.
DR EMBL; AK228285; BAF00231.1; -; mRNA.
DR PIR; D84918; D84918.
DR RefSeq; NP_182291.1; NM_130337.6. [O82238-1]
DR PDB; 7AR7; EM; 3.72 A; e=37-100.
DR PDBsum; 7AR7; -.
DR AlphaFoldDB; O82238; -.
DR SMR; O82238; -.
DR IntAct; O82238; 2.
DR STRING; 3702.AT2G47690.1; -.
DR PaxDb; O82238; -.
DR PRIDE; O82238; -.
DR EnsemblPlants; AT2G47690.1; AT2G47690.1; AT2G47690. [O82238-1]
DR GeneID; 819382; -.
DR Gramene; AT2G47690.1; AT2G47690.1; AT2G47690. [O82238-1]
DR KEGG; ath:AT2G47690; -.
DR Araport; AT2G47690; -.
DR TAIR; locus:2043428; AT2G47690.
DR eggNOG; ENOG502S4B1; Eukaryota.
DR HOGENOM; CLU_162182_1_0_1; -.
DR InParanoid; O82238; -.
DR OMA; AGDGTHN; -.
DR OrthoDB; 1549192at2759; -.
DR PhylomeDB; O82238; -.
DR BioCyc; ARA:AT2G47690-MON; -.
DR BioCyc; MetaCyc:AT2G47690-MON; -.
DR PRO; PR:O82238; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O82238; baseline and differential.
DR Genevisible; O82238; AT.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; IDA:TAIR.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IDA:TAIR.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:0045271; C:respiratory chain complex I; IDA:TAIR.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IBA:GO_Central.
DR GO; GO:0009853; P:photorespiration; TAS:TAIR.
DR InterPro; IPR019342; NADH_UbQ_OxRdtase_FeS-su5.
DR PANTHER; PTHR15224; PTHR15224; 1.
DR Pfam; PF10200; Ndufs5; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Disulfide bond; Electron transport;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Respiratory chain; Transport.
FT CHAIN 1..118
FT /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
FT 5-A"
FT /id="PRO_0000410792"
FT DOMAIN 46..87
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT REGION 98..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 49..59
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 69..79
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 49..79
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 59..69
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 118 AA; 13965 MW; 8CD3DBFB719AC6E5 CRC64;
MDISGHPKTR TRTIFDEVDE PVWFCCVLPI WVGEEMASGW GITGNKGRCY DFWMDFSECM
SHCREPKDCT LLREDYLECL HHSKEFQRRN RIYKEEQRKL RAASRKGEEA GDGTHNHH
