NDUA1_BOVIN
ID NDUA1_BOVIN Reviewed; 70 AA.
AC Q02377; Q3ZC06;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1;
DE AltName: Full=Complex I-MWFE;
DE Short=CI-MWFE;
DE AltName: Full=NADH-ubiquinone oxidoreductase MWFE subunit;
GN Name=NDUFA1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 1-23.
RC TISSUE=Heart;
RX PubMed=1518044; DOI=10.1016/0022-2836(92)91052-q;
RA Walker J.E., Arizmendi J.M., Dupuis A., Fearnley I.M., Finel M., Medd S.M.,
RA Pilkington S.J., Runswick M.J., Skehel J.M.;
RT "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine
RT heart mitochondria. Application of a novel strategy for sequencing proteins
RT using the polymerase chain reaction.";
RL J. Mol. Biol. 226:1051-1072(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Heart ventricle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP SUBUNIT, IDENTIFICATION IN COMPLEX I, AND SUBCELLULAR LOCATION.
RX PubMed=18721790; DOI=10.1016/j.ab.2008.07.029;
RA Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A.,
RA Robinson N.C.;
RT "Subunit analysis of bovine heart complex I by reversed-phase high-
RT performance liquid chromatography, electrospray ionization-tandem mass
RT spectrometry, and matrix-assisted laser desorption/ionization-time-of-
RT flight mass spectrometry.";
RL Anal. Biochem. 382:116-121(2008).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O15239}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000269|PubMed:18721790}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000305|PubMed:18721790}; Single-pass membrane protein
CC {ECO:0000255}; Matrix side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA1 subunit family.
CC {ECO:0000305}.
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DR EMBL; X63222; CAA44907.1; -; mRNA.
DR EMBL; BC102993; AAI02994.1; -; mRNA.
DR PIR; S28252; S28252.
DR RefSeq; NP_786988.1; NM_175794.2.
DR PDB; 5LC5; EM; 4.35 A; a=1-70.
DR PDB; 5LDW; EM; 4.27 A; a=1-70.
DR PDB; 5LDX; EM; 5.60 A; a=1-70.
DR PDB; 5LNK; EM; 3.90 A; z=1-70.
DR PDB; 5O31; EM; 4.13 A; a=1-70.
DR PDB; 7QSD; EM; 3.10 A; a=1-70.
DR PDBsum; 5LC5; -.
DR PDBsum; 5LDW; -.
DR PDBsum; 5LDX; -.
DR PDBsum; 5LNK; -.
DR PDBsum; 5O31; -.
DR PDBsum; 7QSD; -.
DR AlphaFoldDB; Q02377; -.
DR SMR; Q02377; -.
DR CORUM; Q02377; -.
DR DIP; DIP-38822N; -.
DR IntAct; Q02377; 1.
DR STRING; 9913.ENSBTAP00000007925; -.
DR TCDB; 3.D.1.6.1; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR iPTMnet; Q02377; -.
DR PaxDb; Q02377; -.
DR PRIDE; Q02377; -.
DR Ensembl; ENSBTAT00000007925; ENSBTAP00000007925; ENSBTAG00000006033.
DR GeneID; 327673; -.
DR KEGG; bta:327673; -.
DR CTD; 4694; -.
DR VEuPathDB; HostDB:ENSBTAG00000006033; -.
DR VGNC; VGNC:31944; NDUFA1.
DR eggNOG; ENOG502S3S5; Eukaryota.
DR GeneTree; ENSGT00390000007560; -.
DR HOGENOM; CLU_185502_2_0_1; -.
DR InParanoid; Q02377; -.
DR OMA; AYIHKFT; -.
DR OrthoDB; 1608843at2759; -.
DR TreeFam; TF333394; -.
DR Reactome; R-BTA-611105; Respiratory electron transport.
DR Reactome; R-BTA-6799198; Complex I biogenesis.
DR Proteomes; UP000009136; Chromosome X.
DR Bgee; ENSBTAG00000006033; Expressed in retina and 105 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR017384; NADH_Ub_cplx-1_asu_su-1.
DR PANTHER; PTHR17098; PTHR17098; 1.
DR Pfam; PF15879; MWFE; 1.
DR PIRSF; PIRSF038095; NDUA1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Electron transport; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..70
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 1"
FT /id="PRO_0000118814"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 70 AA; 8105 MW; DC64CF71EA573324 CRC64;
MWFEVLPGIA VMGVCLFIPG MATARIHRFS NGGKEKRVAH YPYQWYLMER DRRVSGVNRS
YVSKGLENID
