ID   NDUA1_CRIGR             Reviewed;          70 AA.
AC   Q9WU08;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1;
DE   AltName: Full=Complex I-MWFE;
DE            Short=CI-MWFE;
DE   AltName: Full=NADH-ubiquinone oxidoreductase MWFE subunit;
GN   Name=NDUFA1;
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10200266; DOI=10.1073/pnas.96.8.4354;
RA   Au H.C., Seo B.B., Matsuno-Yagi A., Yagi T., Scheffler I.E.;
RT   "The NDUFA1 gene product (MWFE protein) is essential for activity of
RT   complex I in mammalian mitochondria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:4354-4359(1999).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000250|UniProtKB:O15239}.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:O15239}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O15239}; Single-pass membrane protein
CC       {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O15239}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFA1 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AF100706; AAD25330.1; -; mRNA.
DR   RefSeq; NP_001233690.1; NM_001246761.1.
DR   AlphaFoldDB; Q9WU08; -.
DR   SMR; Q9WU08; -.
DR   STRING; 10029.NP_001233690.1; -.
DR   iPTMnet; Q9WU08; -.
DR   Ensembl; ENSCGRT00001005588; ENSCGRP00001003809; ENSCGRG00001004710.
DR   GeneID; 100689328; -.
DR   KEGG; cge:100689328; -.
DR   CTD; 4694; -.
DR   eggNOG; ENOG502S3S5; Eukaryota.
DR   GeneTree; ENSGT00390000007560; -.
DR   OrthoDB; 1608843at2759; -.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   InterPro; IPR017384; NADH_Ub_cplx-1_asu_su-1.
DR   PANTHER; PTHR17098; PTHR17098; 1.
DR   Pfam; PF15879; MWFE; 1.
DR   PIRSF; PIRSF038095; NDUA1; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..70
FT                   /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT                   subunit 1"
FT                   /id="PRO_0000118815"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   70 AA;  8167 MW;  0B016845450CCDA7 CRC64;
     MWFEILPGLA VMGVCLVIPG VATAYIHKYT NGGKEKRVGR LRYQWYLMER DRRVSGVNRY
     YVSRGLENID