NDUA1_MOUSE
ID NDUA1_MOUSE Reviewed; 70 AA.
AC O35683;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1;
DE AltName: Full=Complex I-MWFE;
DE Short=CI-MWFE;
DE AltName: Full=NADH-ubiquinone oxidoreductase MWFE subunit;
GN Name=Ndufa1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Frattini A., Faranda S., Bagnasco L., Patrosso C., Nulli P., Vezzoni P.;
RL Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O15239}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O15239}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O15239}; Single-pass membrane protein
CC {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O15239}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA1 subunit family.
CC {ECO:0000305}.
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DR EMBL; Y07708; CAA68977.1; -; mRNA.
DR EMBL; BC024364; AAH24364.1; -; mRNA.
DR CCDS; CCDS40928.1; -.
DR RefSeq; NP_062316.1; NM_019443.2.
DR PDB; 6G2J; EM; 3.30 A; a=1-67.
DR PDB; 6G72; EM; 3.90 A; a=1-70.
DR PDB; 6ZR2; EM; 3.10 A; a=1-70.
DR PDB; 6ZTQ; EM; 3.00 A; a=1-70.
DR PDB; 7AK5; EM; 3.17 A; a=1-68.
DR PDB; 7AK6; EM; 3.82 A; a=1-68.
DR PDB; 7B93; EM; 3.04 A; a=1-70.
DR PDB; 7PSA; EM; 3.40 A; a=1-70.
DR PDBsum; 6G2J; -.
DR PDBsum; 6G72; -.
DR PDBsum; 6ZR2; -.
DR PDBsum; 6ZTQ; -.
DR PDBsum; 7AK5; -.
DR PDBsum; 7AK6; -.
DR PDBsum; 7B93; -.
DR PDBsum; 7PSA; -.
DR AlphaFoldDB; O35683; -.
DR SMR; O35683; -.
DR BioGRID; 207651; 2.
DR ComplexPortal; CPX-266; Mitochondrial respiratory chain complex I.
DR CORUM; O35683; -.
DR IntAct; O35683; 1.
DR STRING; 10090.ENSMUSP00000016571; -.
DR iPTMnet; O35683; -.
DR PhosphoSitePlus; O35683; -.
DR EPD; O35683; -.
DR jPOST; O35683; -.
DR PaxDb; O35683; -.
DR PeptideAtlas; O35683; -.
DR PRIDE; O35683; -.
DR ProteomicsDB; 287466; -.
DR Antibodypedia; 29846; 231 antibodies from 27 providers.
DR DNASU; 54405; -.
DR Ensembl; ENSMUST00000016571; ENSMUSP00000016571; ENSMUSG00000016427.
DR GeneID; 54405; -.
DR KEGG; mmu:54405; -.
DR UCSC; uc009syi.1; mouse.
DR CTD; 4694; -.
DR MGI; MGI:1929511; Ndufa1.
DR VEuPathDB; HostDB:ENSMUSG00000016427; -.
DR eggNOG; ENOG502S3S5; Eukaryota.
DR GeneTree; ENSGT00390000007560; -.
DR HOGENOM; CLU_185502_2_0_1; -.
DR InParanoid; O35683; -.
DR OMA; AYIHKFT; -.
DR OrthoDB; 1608843at2759; -.
DR PhylomeDB; O35683; -.
DR TreeFam; TF333394; -.
DR Reactome; R-MMU-611105; Respiratory electron transport.
DR Reactome; R-MMU-6799198; Complex I biogenesis.
DR BioGRID-ORCS; 54405; 28 hits in 71 CRISPR screens.
DR ChiTaRS; Ndufa1; mouse.
DR PRO; PR:O35683; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; O35683; protein.
DR Bgee; ENSMUSG00000016427; Expressed in choroid plexus epithelium and 250 other tissues.
DR ExpressionAtlas; O35683; baseline and differential.
DR Genevisible; O35683; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:MGI.
DR GO; GO:0031966; C:mitochondrial membrane; ISO:MGI.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0009060; P:aerobic respiration; IC:ComplexPortal.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR GO; GO:0042776; P:proton motive force-driven mitochondrial ATP synthesis; IC:ComplexPortal.
DR InterPro; IPR017384; NADH_Ub_cplx-1_asu_su-1.
DR PANTHER; PTHR17098; PTHR17098; 1.
DR Pfam; PF15879; MWFE; 1.
DR PIRSF; PIRSF038095; NDUA1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..70
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 1"
FT /id="PRO_0000118818"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 2..5
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT HELIX 6..31
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT HELIX 42..55
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT STRAND 56..58
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT HELIX 66..68
FT /evidence="ECO:0007829|PDB:7B93"
SQ SEQUENCE 70 AA; 8139 MW; 58CB30E72A275734 CRC64;
MWFEILPGLA IMGVCLVIPG VSTAYIHKFT NGGKEKRVAR VQYQWYLMER DRRISGVNRY
YVSKGLENID
